Fast product release requires active-site water dynamics in carbonic anhydrase

Fast product release requires active-site water dynamics in carbonic anhydrase

Abstract Water plays an essential role in enzyme structure, stability, and the substantial rate enhancement of enzyme catalysis. However, direct observations linking enzyme catalysis and active-site water dynamics pose a significant challenge due to experimental difficulties. By integrating an ultra...

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Main Authors: Jin Kyun Kim, Seon Woo Lim, Hannah Jeong, Cheol Lee, Seoyoon Kim, Dong Woo Son, Rajeev Kumar, Jacob T. Andring, Carrie Lomelino, Jennifer L. Wierman, Aina E. Cohen, Tae Joo Shin, Cheol-Min Ghim, Robert McKenna, Byung Hoon Jo, Duyoung Min, Jeong-Mo Choi, Chae Un Kim
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59645-x
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