Prevalence of Torque Teno Virus, Hepatitis and Cytomegalovirus Infection in Iranian Patients With Different Types of leukemia
Background and Objectives: Torque teno virus (TTV) infection can be seen in different types of leukemia and may affect clinical outcomes. This study aims to investigate the prevalence of TTV, hepatitis B and C virus, and cytomegalovirus (CMV) in Iranian patients with different types of leukemia. Met...
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Qom University of Medical Sciences
2023-08-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
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| Online Access: | http://journal.muq.ac.ir/article-1-3557-en.pdf |
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| author | Marjan Shaheli Ramin Yaghobi Mani Ramzi |
| author_facet | Marjan Shaheli Ramin Yaghobi Mani Ramzi |
| author_sort | Marjan Shaheli |
| collection | DOAJ |
| description | Background and Objectives: Torque teno virus (TTV) infection can be seen in different types of leukemia and may affect clinical outcomes. This study aims to investigate the prevalence of TTV, hepatitis B and C virus, and cytomegalovirus (CMV) in Iranian patients with different types of leukemia.
Methods: In this descriptive cross-sectional study, 95 patients with different types of leukemia participated. The molecular prevalence of TTV infection was evaluated using the semi-nested PCR method. The prevalence of HBs-Ag and HCV-Ab viruses was measured by the ELISA method. Also, the prevalence of active CMV infection was investigated by the semi-quantitative antigenemia test. The data analysis was done in SPSS software version 12 using logistic regression analysis, chi-square test, and Fisher’s exact test.
Results: The TTV infection was found in 40 out of 95 patients (42.1%). The presence of HBs-Ag was reported in 27 out of 95 patients (28.4%). HCV-Ab was found in 18 out of 69 patients (26.1%), and active CMV infection was found in 11 out of 69 (15.9%). Among 40 leukemia patients with TTV infection, 15 (37.5%) had hepatitis B, 14 (35%) had hepatitis C, and 7 (17.5%) had CMV infection.
Conclusion: The high prevalence of single or comorbid TTV infection among Iranian patients with leukemia emphasizes the importance of this virus in causing or aggravating the clinical complications observed in these patients. |
| format | Article |
| id | doaj-art-e3c658b74281448295d16b46f86535dd |
| institution | OA Journals |
| issn | 1735-7799 2008-1375 |
| language | fas |
| publishDate | 2023-08-01 |
| publisher | Qom University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
| spelling | doaj-art-e3c658b74281448295d16b46f86535dd2025-08-20T02:18:50ZfasQom University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum1735-77992008-13752023-08-0117299308Prevalence of Torque Teno Virus, Hepatitis and Cytomegalovirus Infection in Iranian Patients With Different Types of leukemiaMarjan Shaheli0Ramin Yaghobi1Mani Ramzi2 Department of Biology, Faculty of Basic Sciences, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran. Shiraz Transplant Research Center, Shiraz University of Medical Sciences,Shiraz, Iran. Hematology and Bone Marrow Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Background and Objectives: Torque teno virus (TTV) infection can be seen in different types of leukemia and may affect clinical outcomes. This study aims to investigate the prevalence of TTV, hepatitis B and C virus, and cytomegalovirus (CMV) in Iranian patients with different types of leukemia. Methods: In this descriptive cross-sectional study, 95 patients with different types of leukemia participated. The molecular prevalence of TTV infection was evaluated using the semi-nested PCR method. The prevalence of HBs-Ag and HCV-Ab viruses was measured by the ELISA method. Also, the prevalence of active CMV infection was investigated by the semi-quantitative antigenemia test. The data analysis was done in SPSS software version 12 using logistic regression analysis, chi-square test, and Fisher’s exact test. Results: The TTV infection was found in 40 out of 95 patients (42.1%). The presence of HBs-Ag was reported in 27 out of 95 patients (28.4%). HCV-Ab was found in 18 out of 69 patients (26.1%), and active CMV infection was found in 11 out of 69 (15.9%). Among 40 leukemia patients with TTV infection, 15 (37.5%) had hepatitis B, 14 (35%) had hepatitis C, and 7 (17.5%) had CMV infection. Conclusion: The high prevalence of single or comorbid TTV infection among Iranian patients with leukemia emphasizes the importance of this virus in causing or aggravating the clinical complications observed in these patients.http://journal.muq.ac.ir/article-1-3557-en.pdftorque teno virusleukemiahepatitiscytomegalovirus |
| spellingShingle | Marjan Shaheli Ramin Yaghobi Mani Ramzi Prevalence of Torque Teno Virus, Hepatitis and Cytomegalovirus Infection in Iranian Patients With Different Types of leukemia Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum torque teno virus leukemia hepatitis cytomegalovirus |
| title | Prevalence of Torque Teno Virus, Hepatitis and Cytomegalovirus Infection in Iranian Patients With Different Types of leukemia |
| title_full | Prevalence of Torque Teno Virus, Hepatitis and Cytomegalovirus Infection in Iranian Patients With Different Types of leukemia |
| title_fullStr | Prevalence of Torque Teno Virus, Hepatitis and Cytomegalovirus Infection in Iranian Patients With Different Types of leukemia |
| title_full_unstemmed | Prevalence of Torque Teno Virus, Hepatitis and Cytomegalovirus Infection in Iranian Patients With Different Types of leukemia |
| title_short | Prevalence of Torque Teno Virus, Hepatitis and Cytomegalovirus Infection in Iranian Patients With Different Types of leukemia |
| title_sort | prevalence of torque teno virus hepatitis and cytomegalovirus infection in iranian patients with different types of leukemia |
| topic | torque teno virus leukemia hepatitis cytomegalovirus |
| url | http://journal.muq.ac.ir/article-1-3557-en.pdf |
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