Specific features of the establishment of puberty in girls with type 1 diabetes mellitus and related disturbances of menstrualand ovarian functions
Type 1 diabetes mellitus (DM1) exerts negative impact on the formation and functioning of the reproductive system in young girls. The time of onset(especially in the prepubertal period) and duration of DM1 as well as the lack of metabolic control may cause delay of puberty, affect the age of menarch...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2009-12-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/5696 |
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| author | Olga Rafael'evna Grigoryan Anna Alexandrovna Okhotnikova Elena Nikolaevna Andreeva |
| author_facet | Olga Rafael'evna Grigoryan Anna Alexandrovna Okhotnikova Elena Nikolaevna Andreeva |
| author_sort | Olga Rafael'evna Grigoryan |
| collection | DOAJ |
| description | Type 1 diabetes mellitus (DM1) exerts negative impact on the formation and functioning of the reproductive system in young girls. The time of onset(especially in the prepubertal period) and duration of DM1 as well as the lack of metabolic control may cause delay of puberty, affect the age of menarche,and increase the frequency of menstrual disturbances (largely in the form oligo- and amenorrhoea). Despite extensive research devoted to thisproblem, the main cause of reproductive dysfunction in such patients remains unclear even though DM1 is known to negatively affect performanceof the hypothalamo-pituitary axis. Pathogenetic mechanisms behind reproductive disturbances include suppression of GnRH pulses due to enhancedcentral dopamine and opiate activity, decreased expression of insulin receptors on neural cells, and altered plasma leptin level. Pituitary may be affectedboth by hypothalamic activity and by lipid free radical oxidation products decreasing production of tropic hormones (LH and FSH). |
| format | Article |
| id | doaj-art-e3c234b60ad143d18cd96ea2ba5a1d28 |
| institution | DOAJ |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2009-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-e3c234b60ad143d18cd96ea2ba5a1d282025-08-20T03:09:00ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782009-12-01124101410.14341/2072-0351-56965654Specific features of the establishment of puberty in girls with type 1 diabetes mellitus and related disturbances of menstrualand ovarian functionsOlga Rafael'evna Grigoryan0Anna Alexandrovna Okhotnikova1Elena Nikolaevna Andreeva2Endocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowType 1 diabetes mellitus (DM1) exerts negative impact on the formation and functioning of the reproductive system in young girls. The time of onset(especially in the prepubertal period) and duration of DM1 as well as the lack of metabolic control may cause delay of puberty, affect the age of menarche,and increase the frequency of menstrual disturbances (largely in the form oligo- and amenorrhoea). Despite extensive research devoted to thisproblem, the main cause of reproductive dysfunction in such patients remains unclear even though DM1 is known to negatively affect performanceof the hypothalamo-pituitary axis. Pathogenetic mechanisms behind reproductive disturbances include suppression of GnRH pulses due to enhancedcentral dopamine and opiate activity, decreased expression of insulin receptors on neural cells, and altered plasma leptin level. Pituitary may be affectedboth by hypothalamic activity and by lipid free radical oxidation products decreasing production of tropic hormones (LH and FSH).https://www.dia-endojournals.ru/jour/article/view/5696type 1 diabetes mellitusreproductive systempuberty |
| spellingShingle | Olga Rafael'evna Grigoryan Anna Alexandrovna Okhotnikova Elena Nikolaevna Andreeva Specific features of the establishment of puberty in girls with type 1 diabetes mellitus and related disturbances of menstrualand ovarian functions Сахарный диабет type 1 diabetes mellitus reproductive system puberty |
| title | Specific features of the establishment of puberty in girls with type 1 diabetes mellitus and related disturbances of menstrualand ovarian functions |
| title_full | Specific features of the establishment of puberty in girls with type 1 diabetes mellitus and related disturbances of menstrualand ovarian functions |
| title_fullStr | Specific features of the establishment of puberty in girls with type 1 diabetes mellitus and related disturbances of menstrualand ovarian functions |
| title_full_unstemmed | Specific features of the establishment of puberty in girls with type 1 diabetes mellitus and related disturbances of menstrualand ovarian functions |
| title_short | Specific features of the establishment of puberty in girls with type 1 diabetes mellitus and related disturbances of menstrualand ovarian functions |
| title_sort | specific features of the establishment of puberty in girls with type 1 diabetes mellitus and related disturbances of menstrualand ovarian functions |
| topic | type 1 diabetes mellitus reproductive system puberty |
| url | https://www.dia-endojournals.ru/jour/article/view/5696 |
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