Phosphorylated alpha-synuclein distribution in the colonic enteric nervous system of patients with diverticular disease
Background: Phosphorylated alpha-synuclein (P-aSyn) is a biomarker for Parkinson’s disease (PD), with potential relevance in intestinal inflammatory disorders. Objectives: This study examines the distribution of P-aSyn in colonic tissues of patients with diverticular disease (DD) compared to age-mat...
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Elsevier
2025-06-01
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| Series: | IBRO Neuroscience Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242125000272 |
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| author | François Cossais Marie Christin Hörnke Katja Schröder Ralph Lucius Martina Böttner Jan-Hendrik Egberts Florian Richter Thilo Wedel |
| author_facet | François Cossais Marie Christin Hörnke Katja Schröder Ralph Lucius Martina Böttner Jan-Hendrik Egberts Florian Richter Thilo Wedel |
| author_sort | François Cossais |
| collection | DOAJ |
| description | Background: Phosphorylated alpha-synuclein (P-aSyn) is a biomarker for Parkinson’s disease (PD), with potential relevance in intestinal inflammatory disorders. Objectives: This study examines the distribution of P-aSyn in colonic tissues of patients with diverticular disease (DD) compared to age-matched controls. Methods: P-aSyn distribution was analyzed in colon samples of 45 patients with diverticulitis (D-itis), 12 with diverticulosis (D-osis), and 30 controls via immunohistochemistry. Results: P-aSyn immunoreactivity was found along enteric neurons of the myenteric and submucosal plexus in 93.1 % of participants, with similar distribution across D-itis, D-osis, and controls. Elevated reactivity appeared in 16.7 % of D-osis, 19.6 % of D-itis, and 30.0 % of controls. Conclusion: P-aSyn presence in colonic tissue did not significantly differ between DD patients and controls, suggesting that DD-related inflammation does not notably affect P-aSyn expression. Further research is warranted to explore aSyn roles within the enteric nervous system in intestinal inflammatory disorders and their relation with neurodegenerative diseases. |
| format | Article |
| id | doaj-art-e3c1c939d56a4d358863c3bd9c3abc68 |
| institution | OA Journals |
| issn | 2667-2421 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
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| series | IBRO Neuroscience Reports |
| spelling | doaj-art-e3c1c939d56a4d358863c3bd9c3abc682025-08-20T02:06:19ZengElsevierIBRO Neuroscience Reports2667-24212025-06-011838438810.1016/j.ibneur.2025.02.009Phosphorylated alpha-synuclein distribution in the colonic enteric nervous system of patients with diverticular diseaseFrançois Cossais0Marie Christin Hörnke1Katja Schröder2Ralph Lucius3Martina Böttner4Jan-Hendrik Egberts5Florian Richter6Thilo Wedel7Institute of Anatomy, Kiel University, Kiel, Germany; Correspondence to: François Cossais Institute of Anatomy, Kiel University, Olshausentraße 40, Kiel 24118, Germany.Institute of Anatomy, Kiel University, Kiel, GermanyInstitute of Anatomy, Kiel University, Kiel, GermanyInstitute of Anatomy, Kiel University, Kiel, GermanyInstitute of Anatomy, Kiel University, Kiel, GermanyGeneral, Thoracic, Transplantation and Pediatric Surgery, Kiel University, University Medical Center Schleswig-Holstein, Kiel, Germany; Department of Surgery, Israelite Hospital, Hamburg, GermanyGeneral, Thoracic, Transplantation and Pediatric Surgery, Kiel University, University Medical Center Schleswig-Holstein, Kiel, GermanyInstitute of Anatomy, Kiel University, Kiel, GermanyBackground: Phosphorylated alpha-synuclein (P-aSyn) is a biomarker for Parkinson’s disease (PD), with potential relevance in intestinal inflammatory disorders. Objectives: This study examines the distribution of P-aSyn in colonic tissues of patients with diverticular disease (DD) compared to age-matched controls. Methods: P-aSyn distribution was analyzed in colon samples of 45 patients with diverticulitis (D-itis), 12 with diverticulosis (D-osis), and 30 controls via immunohistochemistry. Results: P-aSyn immunoreactivity was found along enteric neurons of the myenteric and submucosal plexus in 93.1 % of participants, with similar distribution across D-itis, D-osis, and controls. Elevated reactivity appeared in 16.7 % of D-osis, 19.6 % of D-itis, and 30.0 % of controls. Conclusion: P-aSyn presence in colonic tissue did not significantly differ between DD patients and controls, suggesting that DD-related inflammation does not notably affect P-aSyn expression. Further research is warranted to explore aSyn roles within the enteric nervous system in intestinal inflammatory disorders and their relation with neurodegenerative diseases.http://www.sciencedirect.com/science/article/pii/S2667242125000272Enteric nervous systemAlpha-synucleinParkinson’s diseaseDiverticular diseaseIntestinal inflammation |
| spellingShingle | François Cossais Marie Christin Hörnke Katja Schröder Ralph Lucius Martina Böttner Jan-Hendrik Egberts Florian Richter Thilo Wedel Phosphorylated alpha-synuclein distribution in the colonic enteric nervous system of patients with diverticular disease IBRO Neuroscience Reports Enteric nervous system Alpha-synuclein Parkinson’s disease Diverticular disease Intestinal inflammation |
| title | Phosphorylated alpha-synuclein distribution in the colonic enteric nervous system of patients with diverticular disease |
| title_full | Phosphorylated alpha-synuclein distribution in the colonic enteric nervous system of patients with diverticular disease |
| title_fullStr | Phosphorylated alpha-synuclein distribution in the colonic enteric nervous system of patients with diverticular disease |
| title_full_unstemmed | Phosphorylated alpha-synuclein distribution in the colonic enteric nervous system of patients with diverticular disease |
| title_short | Phosphorylated alpha-synuclein distribution in the colonic enteric nervous system of patients with diverticular disease |
| title_sort | phosphorylated alpha synuclein distribution in the colonic enteric nervous system of patients with diverticular disease |
| topic | Enteric nervous system Alpha-synuclein Parkinson’s disease Diverticular disease Intestinal inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2667242125000272 |
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