Therapy with canakinumab for adult-onset still's disease
Still's disease in children (systemic-onset juvenile idiopathic arthritis, SoJIA) and in adults (adult-onset Still's disease) are considered as non-familial systemic autoinflammatory diseases of unknown etiology driven by similar immunopathogenetic mechanisms. The adult-onset Still's...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2019-04-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/2688 |
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| author | E. L. Nasonov |
| author_facet | E. L. Nasonov |
| author_sort | E. L. Nasonov |
| collection | DOAJ |
| description | Still's disease in children (systemic-onset juvenile idiopathic arthritis, SoJIA) and in adults (adult-onset Still's disease) are considered as non-familial systemic autoinflammatory diseases of unknown etiology driven by similar immunopathogenetic mechanisms. The adult-onset Still's disease pathogenesis is based on genetically determined innate immunity disturbances and molecular basis of immunopathogenesis consists of NLRP3 inflammasomedependent mechanisms of inflammation characterized by hyperproduction of proinflammatory cytokines interleukin (IL) 1 and IL18. Nonsteroidal anti-inflammatory drugs, glucocorticoids, methotrexate and other disease modifying drugs are considered as «first line» medications for the treatment of adult-onset Still's disease and if they fail biologicals are recommended. A review of the literature data concerning anti-IL1 monoclonal antibodies administration in adult-onset Still's disease is presented, indicating good prospects for the use of canakinumab not only in case of resistance to standard therapy, but also as a «first-line» therapy in the onset of the disease. |
| format | Article |
| id | doaj-art-e3bc6b4e8adc4ed08b3798d33d9dca22 |
| institution | Kabale University |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2019-04-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-e3bc6b4e8adc4ed08b3798d33d9dca222025-08-20T03:37:53ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922019-04-01560354010.14412/1995-4484-2018-35-402463Therapy with canakinumab for adult-onset still's diseaseE. L. Nasonov0V.A. Nasonova Research Institute of Rheumatology; I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaStill's disease in children (systemic-onset juvenile idiopathic arthritis, SoJIA) and in adults (adult-onset Still's disease) are considered as non-familial systemic autoinflammatory diseases of unknown etiology driven by similar immunopathogenetic mechanisms. The adult-onset Still's disease pathogenesis is based on genetically determined innate immunity disturbances and molecular basis of immunopathogenesis consists of NLRP3 inflammasomedependent mechanisms of inflammation characterized by hyperproduction of proinflammatory cytokines interleukin (IL) 1 and IL18. Nonsteroidal anti-inflammatory drugs, glucocorticoids, methotrexate and other disease modifying drugs are considered as «first line» medications for the treatment of adult-onset Still's disease and if they fail biologicals are recommended. A review of the literature data concerning anti-IL1 monoclonal antibodies administration in adult-onset Still's disease is presented, indicating good prospects for the use of canakinumab not only in case of resistance to standard therapy, but also as a «first-line» therapy in the onset of the disease.https://rsp.mediar-press.net/rsp/article/view/2688adult-onset still's diseaseinterleukin 1canakinumab |
| spellingShingle | E. L. Nasonov Therapy with canakinumab for adult-onset still's disease Научно-практическая ревматология adult-onset still's disease interleukin 1 canakinumab |
| title | Therapy with canakinumab for adult-onset still's disease |
| title_full | Therapy with canakinumab for adult-onset still's disease |
| title_fullStr | Therapy with canakinumab for adult-onset still's disease |
| title_full_unstemmed | Therapy with canakinumab for adult-onset still's disease |
| title_short | Therapy with canakinumab for adult-onset still's disease |
| title_sort | therapy with canakinumab for adult onset still s disease |
| topic | adult-onset still's disease interleukin 1 canakinumab |
| url | https://rsp.mediar-press.net/rsp/article/view/2688 |
| work_keys_str_mv | AT elnasonov therapywithcanakinumabforadultonsetstillsdisease |