Investigating the genetic association of mitochondrial DNA copy number with neurodegenerative diseases

Investigating the genetic association of mitochondrial DNA copy number with neurodegenerative diseases

Abstract Objective This study aims to investigate the causal relationship between Mitochondrial DNA (mtDNA) copy number and several common neurodegenerative diseases (NDs). Methods We conducted a bidirectional two-sample Mendelian randomization (MR) analysis using data from genome-wide association s...

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Bibliographic Details
Main Authors: Huan Xia, Zi-Hao Wang, Xiao-Bei Wang, Mei-Rong Gao, Sen Jiang, Xin-Yu Du, Xin-Ling Yang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Neurology
Subjects:
Neurodegenerative diseases
Mitochondrial DNA copy number
Mendelian randomization analysis
Genome-wide association studies
Online Access:https://doi.org/10.1186/s12883-025-04176-7
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