Oxidative balance and survival in osteoporosis: how antioxidant diets and lifestyles reduce mortality risk
BackgroundOsteoporosis (OP) is a global health issue characterized by reduced bone mineral density (BMD) and an elevated risk of fractures. Oxidative stress is implicated in OP pathogenesis, and antioxidant diets and lifestyles may mitigate these effects. This research aims to investigate the correl...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1541661/full |
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| author | Ziyao Ding Ziyao Ding Ziyao Ding Haixu Qi Haixu Qi Haixu Qi Wenbo Li Wenbo Li Wenbo Li Changchang Chen Youwei Li Jun Sun Jun Sun Maji Sun Maji Sun Maji Sun Shuo Feng Shuo Feng Shuo Feng Feng Yuan Feng Yuan Feng Yuan |
| author_facet | Ziyao Ding Ziyao Ding Ziyao Ding Haixu Qi Haixu Qi Haixu Qi Wenbo Li Wenbo Li Wenbo Li Changchang Chen Youwei Li Jun Sun Jun Sun Maji Sun Maji Sun Maji Sun Shuo Feng Shuo Feng Shuo Feng Feng Yuan Feng Yuan Feng Yuan |
| author_sort | Ziyao Ding |
| collection | DOAJ |
| description | BackgroundOsteoporosis (OP) is a global health issue characterized by reduced bone mineral density (BMD) and an elevated risk of fractures. Oxidative stress is implicated in OP pathogenesis, and antioxidant diets and lifestyles may mitigate these effects. This research aims to investigate the correlation between oxidative balance score (OBS) and all-cause mortality in individuals diagnosed with OP.MethodsThis study is based on data from the National Health and Nutrition Examination Survey (NHANES, 2005–2018), which covers 776 OP patients aged 50 or older. OBS was computed using dietary and lifestyle factors, and divided into two categories: dietary oxidative balance score (DOBS) and lifestyle oxidative balance score (LOBS). Participants were grouped into tertiles based on OBS values.ResultsKaplan–Meier survival analysis revealed significantly higher survival in the high OBS group compared to the low OBS group (p = 0.0032). Consistently, weighted Cox proportional hazards models demonstrated a negative association between OBS and all-cause mortality [HR = 0.96, 95% CI (0.94, 0.99), p = 0.0036].ConclusionOBS is inversely correlated with all-cause mortality among OP patients, underscoring the critical role of antioxidant-rich diets and lifestyle modifications in OP prevention and treatment strategies. Incorporating OBS into clinical practice may help identify high-risk individuals and guide targeted interventions to reduce mortality risk. |
| format | Article |
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| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-e3bb7540097f487eb9d7b58773fa567a2025-08-20T03:27:25ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-07-011210.3389/fnut.2025.15416611541661Oxidative balance and survival in osteoporosis: how antioxidant diets and lifestyles reduce mortality riskZiyao Ding0Ziyao Ding1Ziyao Ding2Haixu Qi3Haixu Qi4Haixu Qi5Wenbo Li6Wenbo Li7Wenbo Li8Changchang Chen9Youwei Li10Jun Sun11Jun Sun12Maji Sun13Maji Sun14Maji Sun15Shuo Feng16Shuo Feng17Shuo Feng18Feng Yuan19Feng Yuan20Feng Yuan21First Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaKey Laboratory of Bone Tissue Regeneration and Digital Medicine, Xuzhou Medical University, Xuzhou, ChinaDepartment of Orthopedics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaFirst Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaKey Laboratory of Bone Tissue Regeneration and Digital Medicine, Xuzhou Medical University, Xuzhou, ChinaDepartment of Orthopedics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaFirst Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaKey Laboratory of Bone Tissue Regeneration and Digital Medicine, Xuzhou Medical University, Xuzhou, ChinaDepartment of Orthopedics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaFirst Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaFirst Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaKey Laboratory of Bone Tissue Regeneration and Digital Medicine, Xuzhou Medical University, Xuzhou, ChinaDepartment of Orthopedics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaFirst Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaKey Laboratory of Bone Tissue Regeneration and Digital Medicine, Xuzhou Medical University, Xuzhou, ChinaDepartment of Orthopedics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaFirst Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaKey Laboratory of Bone Tissue Regeneration and Digital Medicine, Xuzhou Medical University, Xuzhou, ChinaDepartment of Orthopedics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaFirst Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaKey Laboratory of Bone Tissue Regeneration and Digital Medicine, Xuzhou Medical University, Xuzhou, ChinaDepartment of Orthopedics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaBackgroundOsteoporosis (OP) is a global health issue characterized by reduced bone mineral density (BMD) and an elevated risk of fractures. Oxidative stress is implicated in OP pathogenesis, and antioxidant diets and lifestyles may mitigate these effects. This research aims to investigate the correlation between oxidative balance score (OBS) and all-cause mortality in individuals diagnosed with OP.MethodsThis study is based on data from the National Health and Nutrition Examination Survey (NHANES, 2005–2018), which covers 776 OP patients aged 50 or older. OBS was computed using dietary and lifestyle factors, and divided into two categories: dietary oxidative balance score (DOBS) and lifestyle oxidative balance score (LOBS). Participants were grouped into tertiles based on OBS values.ResultsKaplan–Meier survival analysis revealed significantly higher survival in the high OBS group compared to the low OBS group (p = 0.0032). Consistently, weighted Cox proportional hazards models demonstrated a negative association between OBS and all-cause mortality [HR = 0.96, 95% CI (0.94, 0.99), p = 0.0036].ConclusionOBS is inversely correlated with all-cause mortality among OP patients, underscoring the critical role of antioxidant-rich diets and lifestyle modifications in OP prevention and treatment strategies. Incorporating OBS into clinical practice may help identify high-risk individuals and guide targeted interventions to reduce mortality risk.https://www.frontiersin.org/articles/10.3389/fnut.2025.1541661/fullosteoporosisoxidative balance scoreantioxidant dietmortality risklifestyle factors |
| spellingShingle | Ziyao Ding Ziyao Ding Ziyao Ding Haixu Qi Haixu Qi Haixu Qi Wenbo Li Wenbo Li Wenbo Li Changchang Chen Youwei Li Jun Sun Jun Sun Maji Sun Maji Sun Maji Sun Shuo Feng Shuo Feng Shuo Feng Feng Yuan Feng Yuan Feng Yuan Oxidative balance and survival in osteoporosis: how antioxidant diets and lifestyles reduce mortality risk Frontiers in Nutrition osteoporosis oxidative balance score antioxidant diet mortality risk lifestyle factors |
| title | Oxidative balance and survival in osteoporosis: how antioxidant diets and lifestyles reduce mortality risk |
| title_full | Oxidative balance and survival in osteoporosis: how antioxidant diets and lifestyles reduce mortality risk |
| title_fullStr | Oxidative balance and survival in osteoporosis: how antioxidant diets and lifestyles reduce mortality risk |
| title_full_unstemmed | Oxidative balance and survival in osteoporosis: how antioxidant diets and lifestyles reduce mortality risk |
| title_short | Oxidative balance and survival in osteoporosis: how antioxidant diets and lifestyles reduce mortality risk |
| title_sort | oxidative balance and survival in osteoporosis how antioxidant diets and lifestyles reduce mortality risk |
| topic | osteoporosis oxidative balance score antioxidant diet mortality risk lifestyle factors |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1541661/full |
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