Impact of the 2015 American Thyroid Association Guidelines on Treatment of Low‐Risk Thyroid Cancer
ABSTRACT Objectives The 2015 American Thyroid Association (ATA) guidelines recommended lobectomy for management of low‐risk differentiated thyroid carcinomas (DTC), aiming to mitigate overtreatment. The primary objective of this study was to assess the impact of the 2015 ATA guidelines on the rates...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-06-01
|
| Series: | Laryngoscope Investigative Otolaryngology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/lio2.70175 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849424640695336960 |
|---|---|
| author | Akash S. Halagur Jeffrey D. Huynh Uchechukwu C. Megwalu |
| author_facet | Akash S. Halagur Jeffrey D. Huynh Uchechukwu C. Megwalu |
| author_sort | Akash S. Halagur |
| collection | DOAJ |
| description | ABSTRACT Objectives The 2015 American Thyroid Association (ATA) guidelines recommended lobectomy for management of low‐risk differentiated thyroid carcinomas (DTC), aiming to mitigate overtreatment. The primary objective of this study was to assess the impact of the 2015 ATA guidelines on the rates of lobectomy versus total thyroidectomy for the treatment of low‐risk DTC, using the Surveillance, Epidemiology, and End Results (SEER) 17 database. Our secondary objectives were to examine the modifying effects of tumor size on the change in the rates of lobectomy between the pre‐ and post‐guideline periods and to identify factors that are associated with the use of lobectomy in the post‐guideline period. Methods A retrospective cohort analysis of adults diagnosed with low‐risk DTC from 2011 to 2020 was conducted using the SEER 17 database. Logistic regression assessed the likelihood of lobectomy and total thyroidectomy before and after guideline implementation, including size‐stratified and post‐guideline subgroup analyses. Results Among 61,078 patients, lobectomy rates increased from 16% pre‐guideline to 25% post‐guideline (aOR 1.81, 95% CI 1.74–1.89). Lobectomy increased across both T1 and T2 tumors; post‐guideline subgroup analysis indicates T2 tumors were less likely to receive lobectomy than T1 tumors. Conclusions The use of lobectomy for treatment of low‐risk DTC has significantly increased since the publication of the 2015 ATA guidelines. However, total thyroidectomy remains the predominant treatment. Level of Evidence Level 3. |
| format | Article |
| id | doaj-art-e3b768244a9a4d77856586dc4517aff9 |
| institution | Kabale University |
| issn | 2378-8038 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Laryngoscope Investigative Otolaryngology |
| spelling | doaj-art-e3b768244a9a4d77856586dc4517aff92025-08-20T03:30:04ZengWileyLaryngoscope Investigative Otolaryngology2378-80382025-06-01103n/an/a10.1002/lio2.70175Impact of the 2015 American Thyroid Association Guidelines on Treatment of Low‐Risk Thyroid CancerAkash S. Halagur0Jeffrey D. Huynh1Uchechukwu C. Megwalu2Department of Otolaryngology—Head and Neck Surgery Stanford University School of Medicine Stanford California USADepartment of Otolaryngology—Head and Neck Surgery Stanford University School of Medicine Stanford California USADepartment of Otolaryngology—Head and Neck Surgery Stanford University School of Medicine Stanford California USAABSTRACT Objectives The 2015 American Thyroid Association (ATA) guidelines recommended lobectomy for management of low‐risk differentiated thyroid carcinomas (DTC), aiming to mitigate overtreatment. The primary objective of this study was to assess the impact of the 2015 ATA guidelines on the rates of lobectomy versus total thyroidectomy for the treatment of low‐risk DTC, using the Surveillance, Epidemiology, and End Results (SEER) 17 database. Our secondary objectives were to examine the modifying effects of tumor size on the change in the rates of lobectomy between the pre‐ and post‐guideline periods and to identify factors that are associated with the use of lobectomy in the post‐guideline period. Methods A retrospective cohort analysis of adults diagnosed with low‐risk DTC from 2011 to 2020 was conducted using the SEER 17 database. Logistic regression assessed the likelihood of lobectomy and total thyroidectomy before and after guideline implementation, including size‐stratified and post‐guideline subgroup analyses. Results Among 61,078 patients, lobectomy rates increased from 16% pre‐guideline to 25% post‐guideline (aOR 1.81, 95% CI 1.74–1.89). Lobectomy increased across both T1 and T2 tumors; post‐guideline subgroup analysis indicates T2 tumors were less likely to receive lobectomy than T1 tumors. Conclusions The use of lobectomy for treatment of low‐risk DTC has significantly increased since the publication of the 2015 ATA guidelines. However, total thyroidectomy remains the predominant treatment. Level of Evidence Level 3.https://doi.org/10.1002/lio2.70175American Thyroid Association guidelineslobectomylow‐risk differentiated thyroid carcinomaSEER databasetotal thyroidectomy |
| spellingShingle | Akash S. Halagur Jeffrey D. Huynh Uchechukwu C. Megwalu Impact of the 2015 American Thyroid Association Guidelines on Treatment of Low‐Risk Thyroid Cancer Laryngoscope Investigative Otolaryngology American Thyroid Association guidelines lobectomy low‐risk differentiated thyroid carcinoma SEER database total thyroidectomy |
| title | Impact of the 2015 American Thyroid Association Guidelines on Treatment of Low‐Risk Thyroid Cancer |
| title_full | Impact of the 2015 American Thyroid Association Guidelines on Treatment of Low‐Risk Thyroid Cancer |
| title_fullStr | Impact of the 2015 American Thyroid Association Guidelines on Treatment of Low‐Risk Thyroid Cancer |
| title_full_unstemmed | Impact of the 2015 American Thyroid Association Guidelines on Treatment of Low‐Risk Thyroid Cancer |
| title_short | Impact of the 2015 American Thyroid Association Guidelines on Treatment of Low‐Risk Thyroid Cancer |
| title_sort | impact of the 2015 american thyroid association guidelines on treatment of low risk thyroid cancer |
| topic | American Thyroid Association guidelines lobectomy low‐risk differentiated thyroid carcinoma SEER database total thyroidectomy |
| url | https://doi.org/10.1002/lio2.70175 |
| work_keys_str_mv | AT akashshalagur impactofthe2015americanthyroidassociationguidelinesontreatmentoflowriskthyroidcancer AT jeffreydhuynh impactofthe2015americanthyroidassociationguidelinesontreatmentoflowriskthyroidcancer AT uchechukwucmegwalu impactofthe2015americanthyroidassociationguidelinesontreatmentoflowriskthyroidcancer |