Fully Implantable Wireless Cardiac Pacing and Sensing System Integrated with Hydrogel Electrodes
Abstract Cardiac pacemakers play a crucial role in arrhythmia treatment. Existing devices typically rely on rigid electrode components, leading to potential issues such as heart damage and detachment during prolonged cardiac motion due to the mechanical mismatch with cardiac tissue. Additionally, tr...
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Wiley
2024-11-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202401982 |
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| author | Zhiqiang Chang Bingfang Wang Qinjuan Ren Jianfang Nie Bihan Guo Yuhan Lu Xinxin Lu Ya Zhang Daizong Ji Yingying Lv Menahem Y. Rotenberg Yin Fang |
| author_facet | Zhiqiang Chang Bingfang Wang Qinjuan Ren Jianfang Nie Bihan Guo Yuhan Lu Xinxin Lu Ya Zhang Daizong Ji Yingying Lv Menahem Y. Rotenberg Yin Fang |
| author_sort | Zhiqiang Chang |
| collection | DOAJ |
| description | Abstract Cardiac pacemakers play a crucial role in arrhythmia treatment. Existing devices typically rely on rigid electrode components, leading to potential issues such as heart damage and detachment during prolonged cardiac motion due to the mechanical mismatch with cardiac tissue. Additionally, traditional pacemakers, with their batteries and percutaneous leads, introduce infection risks and limit freedom of movement. A wireless, battery‐free multifunctional bioelectronic device for cardiac pacing is developed. This device integrates highly conductive (160 S m−1), flexible (Young's modulus of 80 kPa is similar to that of mammalian heart tissue), and stretchable (270%) soft hydrogel electrodes, providing high signal‐to‐noise ratio (≈28 dB) electrocardiogram (ECG) recordings and effective pacing of the beating heart. The versatile device detects physiological and biochemical signals in the cardiac environment and allows for adjustable pacing in vivo studies. Remarkably, it maintained recording and pacing capabilities 31 days post‐implantation in rats. Additionally, the wireless bioelectronic device can be fully implanted in rabbits for pacing. By addressing a major shortcoming of conventional pacemakers, this device paves the way for implantable flexible bioelectronics, which offers promising opportunities for advanced cardiac therapies. |
| format | Article |
| id | doaj-art-e3b6a6bb56ad4d72be5aaff7bda1ab09 |
| institution | OA Journals |
| issn | 2198-3844 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-e3b6a6bb56ad4d72be5aaff7bda1ab092025-08-20T01:52:38ZengWileyAdvanced Science2198-38442024-11-011144n/an/a10.1002/advs.202401982Fully Implantable Wireless Cardiac Pacing and Sensing System Integrated with Hydrogel ElectrodesZhiqiang Chang0Bingfang Wang1Qinjuan Ren2Jianfang Nie3Bihan Guo4Yuhan Lu5Xinxin Lu6Ya Zhang7Daizong Ji8Yingying Lv9Menahem Y. Rotenberg10Yin Fang11Research Center for Translational Medicine Medical Innovation Center and State Key Laboratory of Cardiology Shanghai East Hospital The Institute for Biomedical Engineering & Nano Science Tongji University School of Medicine Shanghai 200120 ChinaResearch Center for Translational Medicine Medical Innovation Center and State Key Laboratory of Cardiology Shanghai East Hospital The Institute for Biomedical Engineering & Nano Science Tongji University School of Medicine Shanghai 200120 ChinaResearch Center for Translational Medicine Medical Innovation Center and State Key Laboratory of Cardiology Shanghai East Hospital The Institute for Biomedical Engineering & Nano Science Tongji University School of Medicine Shanghai 200120 ChinaResearch Center for Translational Medicine Medical Innovation Center and State Key Laboratory of Cardiology Shanghai East Hospital The Institute for Biomedical Engineering & Nano Science Tongji University School of Medicine Shanghai 200120 ChinaResearch Center for Translational Medicine Medical Innovation Center and State Key Laboratory of Cardiology Shanghai East Hospital The Institute for Biomedical Engineering & Nano Science Tongji University School of Medicine Shanghai 200120 ChinaResearch Center for Translational Medicine Medical Innovation Center and State Key Laboratory of Cardiology Shanghai East Hospital The Institute for Biomedical Engineering & Nano Science Tongji University School of Medicine Shanghai 200120 ChinaResearch Center for Translational Medicine Medical Innovation Center and State Key Laboratory of Cardiology Shanghai East Hospital The Institute for Biomedical Engineering & Nano Science Tongji University School of Medicine Shanghai 200120 ChinaResearch Center for Translational Medicine Medical Innovation Center and State Key Laboratory of Cardiology Shanghai East Hospital The Institute for Biomedical Engineering & Nano Science Tongji University School of Medicine Shanghai 200120 ChinaResearch Center for Translational Medicine Medical Innovation Center and State Key Laboratory of Cardiology Shanghai East Hospital The Institute for Biomedical Engineering & Nano Science Tongji University School of Medicine Shanghai 200120 ChinaResearch Centre of Nanoscience and Nanotechnology College of Science Shanghai University Shanghai 200444 ChinaDepartment of Biomedical Engineering Technion – Israel Institute of Technology Haifa 32000 IsraelResearch Center for Translational Medicine Medical Innovation Center and State Key Laboratory of Cardiology Shanghai East Hospital The Institute for Biomedical Engineering & Nano Science Tongji University School of Medicine Shanghai 200120 ChinaAbstract Cardiac pacemakers play a crucial role in arrhythmia treatment. Existing devices typically rely on rigid electrode components, leading to potential issues such as heart damage and detachment during prolonged cardiac motion due to the mechanical mismatch with cardiac tissue. Additionally, traditional pacemakers, with their batteries and percutaneous leads, introduce infection risks and limit freedom of movement. A wireless, battery‐free multifunctional bioelectronic device for cardiac pacing is developed. This device integrates highly conductive (160 S m−1), flexible (Young's modulus of 80 kPa is similar to that of mammalian heart tissue), and stretchable (270%) soft hydrogel electrodes, providing high signal‐to‐noise ratio (≈28 dB) electrocardiogram (ECG) recordings and effective pacing of the beating heart. The versatile device detects physiological and biochemical signals in the cardiac environment and allows for adjustable pacing in vivo studies. Remarkably, it maintained recording and pacing capabilities 31 days post‐implantation in rats. Additionally, the wireless bioelectronic device can be fully implanted in rabbits for pacing. By addressing a major shortcoming of conventional pacemakers, this device paves the way for implantable flexible bioelectronics, which offers promising opportunities for advanced cardiac therapies.https://doi.org/10.1002/advs.202401982cardiac pacing systemconductive hydrogel electrodeimplantablewireless and battery‐free |
| spellingShingle | Zhiqiang Chang Bingfang Wang Qinjuan Ren Jianfang Nie Bihan Guo Yuhan Lu Xinxin Lu Ya Zhang Daizong Ji Yingying Lv Menahem Y. Rotenberg Yin Fang Fully Implantable Wireless Cardiac Pacing and Sensing System Integrated with Hydrogel Electrodes Advanced Science cardiac pacing system conductive hydrogel electrode implantable wireless and battery‐free |
| title | Fully Implantable Wireless Cardiac Pacing and Sensing System Integrated with Hydrogel Electrodes |
| title_full | Fully Implantable Wireless Cardiac Pacing and Sensing System Integrated with Hydrogel Electrodes |
| title_fullStr | Fully Implantable Wireless Cardiac Pacing and Sensing System Integrated with Hydrogel Electrodes |
| title_full_unstemmed | Fully Implantable Wireless Cardiac Pacing and Sensing System Integrated with Hydrogel Electrodes |
| title_short | Fully Implantable Wireless Cardiac Pacing and Sensing System Integrated with Hydrogel Electrodes |
| title_sort | fully implantable wireless cardiac pacing and sensing system integrated with hydrogel electrodes |
| topic | cardiac pacing system conductive hydrogel electrode implantable wireless and battery‐free |
| url | https://doi.org/10.1002/advs.202401982 |
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