Saturation effects of pre-pregnancy BMI on infant birth weight in Jiangxi Province, China: a retrospective study
Abstract There were limited analyses on relationship between body mass index (BMI) pre-pregnancy, as well as birth weight. Research aimed to examine the relation between these two, as well as low birth weight (LBW) risk in Jiangxi Province, China. A total of 1193 pregnant subjects from Jiangxi Provi...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-05-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-02677-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850269032474738688 |
|---|---|
| author | Jun Xiong Huan Li Xiao-Qing Tan Xiao-Ju He Wen-Yan Fu |
| author_facet | Jun Xiong Huan Li Xiao-Qing Tan Xiao-Ju He Wen-Yan Fu |
| author_sort | Jun Xiong |
| collection | DOAJ |
| description | Abstract There were limited analyses on relationship between body mass index (BMI) pre-pregnancy, as well as birth weight. Research aimed to examine the relation between these two, as well as low birth weight (LBW) risk in Jiangxi Province, China. A total of 1193 pregnant subjects from Jiangxi Province, China were enrolled in the final analysis. Standardized questionnaires were administered to the women during childbirth, newborns’ medical information was obtained from hospital records. Pre-pregnancy BMI was categorized into underweight, normal, overweight, and obese groups. Multivariate linear regression models were employed to assess connection between pre-pregnancy BMI, birth weight. We utilized generalized additive model and fitted smoothing curve (penalized spline method) to examine relationship between pre-pregnancy BMI and birth weight, as well as LBW risk. The incidence of LBW was 12.1%, with average pre-pregnancy BMI of 20.9 ± 2.5 kg/m2. The smoothing curve revealed an L-shaped association between pre-pregnancy BMI, birth weight and LBW risk. The curve indicated that as pre-pregnancy BMI increased, LBW risk initially decreased and then plateaued, while birth weight initially escalated and then plateaued. The inflection point for pre-pregnancy BMI was identified as 22 kg/m2. On the left side of inflection point, β (95% CI) for birth weight was 0.04 (0.02, 0.07), and ORs (95% CIs) for LBW risk were 0.78 (0.69, 0.89), on the right side the corresponding values were − 0.00 (-0.03, 0.03) and 1.02 (0.88, 1.19), respectively. All the outcomes presented to be similar in various subgroups. Within a specific range (BMI<22 kg/m2), the correlation between pre-pregnancy BMI and birth weight is statistically significant. This research indicated pre-pregnancy BMI demonstrates a saturation effect on birth weight and LBW risk among Jiangxi Province population. |
| format | Article |
| id | doaj-art-e3b5355d3238439793567f53f52362be |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-e3b5355d3238439793567f53f52362be2025-08-20T01:53:18ZengNature PortfolioScientific Reports2045-23222025-05-011511910.1038/s41598-025-02677-6Saturation effects of pre-pregnancy BMI on infant birth weight in Jiangxi Province, China: a retrospective studyJun Xiong0Huan Li1Xiao-Qing Tan2Xiao-Ju He3Wen-Yan Fu4Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang UniversityNanchang UniversityNanchang UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang UniversityDepartment of Pharmacy, The Second Affiliated Hospital of Nanchang UniversityAbstract There were limited analyses on relationship between body mass index (BMI) pre-pregnancy, as well as birth weight. Research aimed to examine the relation between these two, as well as low birth weight (LBW) risk in Jiangxi Province, China. A total of 1193 pregnant subjects from Jiangxi Province, China were enrolled in the final analysis. Standardized questionnaires were administered to the women during childbirth, newborns’ medical information was obtained from hospital records. Pre-pregnancy BMI was categorized into underweight, normal, overweight, and obese groups. Multivariate linear regression models were employed to assess connection between pre-pregnancy BMI, birth weight. We utilized generalized additive model and fitted smoothing curve (penalized spline method) to examine relationship between pre-pregnancy BMI and birth weight, as well as LBW risk. The incidence of LBW was 12.1%, with average pre-pregnancy BMI of 20.9 ± 2.5 kg/m2. The smoothing curve revealed an L-shaped association between pre-pregnancy BMI, birth weight and LBW risk. The curve indicated that as pre-pregnancy BMI increased, LBW risk initially decreased and then plateaued, while birth weight initially escalated and then plateaued. The inflection point for pre-pregnancy BMI was identified as 22 kg/m2. On the left side of inflection point, β (95% CI) for birth weight was 0.04 (0.02, 0.07), and ORs (95% CIs) for LBW risk were 0.78 (0.69, 0.89), on the right side the corresponding values were − 0.00 (-0.03, 0.03) and 1.02 (0.88, 1.19), respectively. All the outcomes presented to be similar in various subgroups. Within a specific range (BMI<22 kg/m2), the correlation between pre-pregnancy BMI and birth weight is statistically significant. This research indicated pre-pregnancy BMI demonstrates a saturation effect on birth weight and LBW risk among Jiangxi Province population.https://doi.org/10.1038/s41598-025-02677-6Pre-pregnancy BMILow birth weightBirth weightJiangxi |
| spellingShingle | Jun Xiong Huan Li Xiao-Qing Tan Xiao-Ju He Wen-Yan Fu Saturation effects of pre-pregnancy BMI on infant birth weight in Jiangxi Province, China: a retrospective study Scientific Reports Pre-pregnancy BMI Low birth weight Birth weight Jiangxi |
| title | Saturation effects of pre-pregnancy BMI on infant birth weight in Jiangxi Province, China: a retrospective study |
| title_full | Saturation effects of pre-pregnancy BMI on infant birth weight in Jiangxi Province, China: a retrospective study |
| title_fullStr | Saturation effects of pre-pregnancy BMI on infant birth weight in Jiangxi Province, China: a retrospective study |
| title_full_unstemmed | Saturation effects of pre-pregnancy BMI on infant birth weight in Jiangxi Province, China: a retrospective study |
| title_short | Saturation effects of pre-pregnancy BMI on infant birth weight in Jiangxi Province, China: a retrospective study |
| title_sort | saturation effects of pre pregnancy bmi on infant birth weight in jiangxi province china a retrospective study |
| topic | Pre-pregnancy BMI Low birth weight Birth weight Jiangxi |
| url | https://doi.org/10.1038/s41598-025-02677-6 |
| work_keys_str_mv | AT junxiong saturationeffectsofprepregnancybmioninfantbirthweightinjiangxiprovincechinaaretrospectivestudy AT huanli saturationeffectsofprepregnancybmioninfantbirthweightinjiangxiprovincechinaaretrospectivestudy AT xiaoqingtan saturationeffectsofprepregnancybmioninfantbirthweightinjiangxiprovincechinaaretrospectivestudy AT xiaojuhe saturationeffectsofprepregnancybmioninfantbirthweightinjiangxiprovincechinaaretrospectivestudy AT wenyanfu saturationeffectsofprepregnancybmioninfantbirthweightinjiangxiprovincechinaaretrospectivestudy |