Elucidating shared genetic association between female body mass index and preeclampsia
Abstract The prevalence of obesity is steadily rising and poses a significant challenge to women’s health. Preeclampsia (PE), a leading cause of maternal and fetal mortality, is significantly linked to a high body mass index (BMI). However, the shared genetic architecture underlying these conditions...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-02-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-07726-4 |
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| author | Fengmei Yang Zhijian Zha Fang Gao Man Wang Enfu Du Ziyang Wang Lei Zhou Bo Gao Si Li Danfeng Zhang |
| author_facet | Fengmei Yang Zhijian Zha Fang Gao Man Wang Enfu Du Ziyang Wang Lei Zhou Bo Gao Si Li Danfeng Zhang |
| author_sort | Fengmei Yang |
| collection | DOAJ |
| description | Abstract The prevalence of obesity is steadily rising and poses a significant challenge to women’s health. Preeclampsia (PE), a leading cause of maternal and fetal mortality, is significantly linked to a high body mass index (BMI). However, the shared genetic architecture underlying these conditions remains poorly understood. In this study, we used summary-level data from large-scale genome-wide association studies of BMI (N = 434,794) and PE (Ncases = 8185; Ncontrols = 234,147) to assess the shared genetic architecture between them. Our findings revealed a significant genetic correlation between BMI and PE, with an estimated sample overlap of approximately 0.8%. We identified roughly 1100 shared genetic variants, with the most notable region of local genetic correlation located in 16q12.2. Enrichment analyses highlighted endothelial dysfunction as a key biological mechanism linking BMI and PE. Additionally, RABEP2 was identified as a novel shared risk gene. Mendelian randomization analysis demonstrated a bidirectional causal relationship between BMI and PE, with blood pressure identified as a key mediator. We identified the shared genetic foundation between BMI and PE, providing valuable insights into the comorbidity of these conditions and offering a new framework for future research into comorbidity. |
| format | Article |
| id | doaj-art-e3b3abdbc8944e6ab9a3b5509ca5531a |
| institution | DOAJ |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-e3b3abdbc8944e6ab9a3b5509ca5531a2025-08-20T03:03:40ZengNature PortfolioCommunications Biology2399-36422025-02-01811910.1038/s42003-025-07726-4Elucidating shared genetic association between female body mass index and preeclampsiaFengmei Yang0Zhijian Zha1Fang Gao2Man Wang3Enfu Du4Ziyang Wang5Lei Zhou6Bo Gao7Si Li8Danfeng Zhang9Taihe Hospital, Hubei University of MedicineCollege of Traditional Chinese Medicine, Hubei University of Chinese MedicineXiangzhou District People’s HospitalTaihe Hospital, Hubei University of MedicineTaihe Hospital, Hubei University of MedicineInstitute of Medicine Nursing, Hubei University of MedicineTaihe Hospital, Hubei University of MedicineTaihe Hospital, Hubei University of MedicineDepartment of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyTaihe Hospital, Hubei University of MedicineAbstract The prevalence of obesity is steadily rising and poses a significant challenge to women’s health. Preeclampsia (PE), a leading cause of maternal and fetal mortality, is significantly linked to a high body mass index (BMI). However, the shared genetic architecture underlying these conditions remains poorly understood. In this study, we used summary-level data from large-scale genome-wide association studies of BMI (N = 434,794) and PE (Ncases = 8185; Ncontrols = 234,147) to assess the shared genetic architecture between them. Our findings revealed a significant genetic correlation between BMI and PE, with an estimated sample overlap of approximately 0.8%. We identified roughly 1100 shared genetic variants, with the most notable region of local genetic correlation located in 16q12.2. Enrichment analyses highlighted endothelial dysfunction as a key biological mechanism linking BMI and PE. Additionally, RABEP2 was identified as a novel shared risk gene. Mendelian randomization analysis demonstrated a bidirectional causal relationship between BMI and PE, with blood pressure identified as a key mediator. We identified the shared genetic foundation between BMI and PE, providing valuable insights into the comorbidity of these conditions and offering a new framework for future research into comorbidity.https://doi.org/10.1038/s42003-025-07726-4 |
| spellingShingle | Fengmei Yang Zhijian Zha Fang Gao Man Wang Enfu Du Ziyang Wang Lei Zhou Bo Gao Si Li Danfeng Zhang Elucidating shared genetic association between female body mass index and preeclampsia Communications Biology |
| title | Elucidating shared genetic association between female body mass index and preeclampsia |
| title_full | Elucidating shared genetic association between female body mass index and preeclampsia |
| title_fullStr | Elucidating shared genetic association between female body mass index and preeclampsia |
| title_full_unstemmed | Elucidating shared genetic association between female body mass index and preeclampsia |
| title_short | Elucidating shared genetic association between female body mass index and preeclampsia |
| title_sort | elucidating shared genetic association between female body mass index and preeclampsia |
| url | https://doi.org/10.1038/s42003-025-07726-4 |
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