Dedifferentiated liposarcoma of the anterior mediastinum: An uncommon case presentation and complex diagnosis
Mediastinal liposarcoma are rare occurrences of liposarcomas, arising from mesenchymal fat cells. They have several histological subtypes including well-differentiated, dedifferentiated, myxoid and pleomorphic. They often present with nonspecific symptoms of mass effect on nearby structures. Surgica...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043325002444 |
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| author | Charles K. Crawford, BS Hajra Arshad, MD Elliot K. Fishman, MD |
| author_facet | Charles K. Crawford, BS Hajra Arshad, MD Elliot K. Fishman, MD |
| author_sort | Charles K. Crawford, BS |
| collection | DOAJ |
| description | Mediastinal liposarcoma are rare occurrences of liposarcomas, arising from mesenchymal fat cells. They have several histological subtypes including well-differentiated, dedifferentiated, myxoid and pleomorphic. They often present with nonspecific symptoms of mass effect on nearby structures. Surgical resection is the mainstay of treatment, but high recurrence rate remains a challenge. We present the case of a 70-year-old male with a large dedifferentiated anterior mediastinal liposarcoma presenting with compressive symptoms. Coordinated efforts from radiology, histopathology and surgical teams are required for timely and accurate diagnosis and an optimized course of treatment. |
| format | Article |
| id | doaj-art-e3b265c33bfc456d92ece0044d5af68f |
| institution | DOAJ |
| issn | 1930-0433 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj-art-e3b265c33bfc456d92ece0044d5af68f2025-08-20T03:03:38ZengElsevierRadiology Case Reports1930-04332025-06-012063076308010.1016/j.radcr.2025.03.035Dedifferentiated liposarcoma of the anterior mediastinum: An uncommon case presentation and complex diagnosisCharles K. Crawford, BS0Hajra Arshad, MD1Elliot K. Fishman, MD2Corresponding author.; Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USADepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USADepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USAMediastinal liposarcoma are rare occurrences of liposarcomas, arising from mesenchymal fat cells. They have several histological subtypes including well-differentiated, dedifferentiated, myxoid and pleomorphic. They often present with nonspecific symptoms of mass effect on nearby structures. Surgical resection is the mainstay of treatment, but high recurrence rate remains a challenge. We present the case of a 70-year-old male with a large dedifferentiated anterior mediastinal liposarcoma presenting with compressive symptoms. Coordinated efforts from radiology, histopathology and surgical teams are required for timely and accurate diagnosis and an optimized course of treatment.http://www.sciencedirect.com/science/article/pii/S1930043325002444Dedifferentiated liposarcomaMediastinumComputed tomography (CT) |
| spellingShingle | Charles K. Crawford, BS Hajra Arshad, MD Elliot K. Fishman, MD Dedifferentiated liposarcoma of the anterior mediastinum: An uncommon case presentation and complex diagnosis Radiology Case Reports Dedifferentiated liposarcoma Mediastinum Computed tomography (CT) |
| title | Dedifferentiated liposarcoma of the anterior mediastinum: An uncommon case presentation and complex diagnosis |
| title_full | Dedifferentiated liposarcoma of the anterior mediastinum: An uncommon case presentation and complex diagnosis |
| title_fullStr | Dedifferentiated liposarcoma of the anterior mediastinum: An uncommon case presentation and complex diagnosis |
| title_full_unstemmed | Dedifferentiated liposarcoma of the anterior mediastinum: An uncommon case presentation and complex diagnosis |
| title_short | Dedifferentiated liposarcoma of the anterior mediastinum: An uncommon case presentation and complex diagnosis |
| title_sort | dedifferentiated liposarcoma of the anterior mediastinum an uncommon case presentation and complex diagnosis |
| topic | Dedifferentiated liposarcoma Mediastinum Computed tomography (CT) |
| url | http://www.sciencedirect.com/science/article/pii/S1930043325002444 |
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