Subthalamic Nucleus Oscillatory Characteristics in Meige, Cervical Dystonia and Generalized Dystonia
ABSTRACT Objective Deep brain stimulation offers a unique opportunity to record neural activity of the basal ganglia. While much work in dystonia has focused on the globus pallidus internus, expanding research to investigate subthalamic nucleus (STN) activity in various dystonia types is critical to...
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| Language: | English |
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Wiley
2025-05-01
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| Series: | Annals of Clinical and Translational Neurology |
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| Online Access: | https://doi.org/10.1002/acn3.70040 |
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| author | Zhu Guan‐Yu Yin Zi‐Xiao Chen Ying‐Chuan Timon Merk Thomas Binns Ma Ruo‐Yu Du Ting‐Ting Liu Yu‐Ye Xie Hu‐Tao Shi Lin Yang An‐Chao Meng Fan‐Gang Wolf‐Julian Neumann Andrea A. Kühn Zhang Jian‐Guo |
| author_facet | Zhu Guan‐Yu Yin Zi‐Xiao Chen Ying‐Chuan Timon Merk Thomas Binns Ma Ruo‐Yu Du Ting‐Ting Liu Yu‐Ye Xie Hu‐Tao Shi Lin Yang An‐Chao Meng Fan‐Gang Wolf‐Julian Neumann Andrea A. Kühn Zhang Jian‐Guo |
| author_sort | Zhu Guan‐Yu |
| collection | DOAJ |
| description | ABSTRACT Objective Deep brain stimulation offers a unique opportunity to record neural activity of the basal ganglia. While much work in dystonia has focused on the globus pallidus internus, expanding research to investigate subthalamic nucleus (STN) activity in various dystonia types is critical to provide a comprehensive understanding of dystonia pathophysiology. Methods STN and cortex activity were recorded from 17 patients with cervical dystonia (CD), 19 with Meige syndrome, and 9 with generalized dystonia (GD) during the lead externalized period. We investigated local and network oscillatory characteristics, including power, bursts, and coherence. Additionally, we explored the relationship between these features and the severity of dystonic symptoms within each group and conducted a comparative analysis across the different dystonia types. Results Peaks of low‐frequency (4–13 Hz) and beta (14–30 Hz) power were present in the STN of all patients; most of the beta peaks are distributed in the high beta range (20–30 Hz). The CD and GD groups showed longer low‐frequency bursts and greater high beta power in STN than the Meige group. Interestingly, the CD group showed stronger STN‐cortex low‐frequency coherence, while the GD group had stronger STN‐cortex high beta coherence. Combined, low‐frequency and beta features could predict symptom severity with a performance of 73% in the CD group and 82% in the GD group. Interpretation Low‐frequency and high‐beta oscillations are present in the STN across all three types of dystonia. The distinct patterns may be associated with different underlying pathological mechanisms. |
| format | Article |
| id | doaj-art-e3b1dcea04f14cc788eea8664901663a |
| institution | Kabale University |
| issn | 2328-9503 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj-art-e3b1dcea04f14cc788eea8664901663a2025-08-20T03:47:28ZengWileyAnnals of Clinical and Translational Neurology2328-95032025-05-011251082109210.1002/acn3.70040Subthalamic Nucleus Oscillatory Characteristics in Meige, Cervical Dystonia and Generalized DystoniaZhu Guan‐Yu0Yin Zi‐Xiao1Chen Ying‐Chuan2Timon Merk3Thomas Binns4Ma Ruo‐Yu5Du Ting‐Ting6Liu Yu‐Ye7Xie Hu‐Tao8Shi Lin9Yang An‐Chao10Meng Fan‐Gang11Wolf‐Julian Neumann12Andrea A. Kühn13Zhang Jian‐Guo14Department of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing ChinaMovement Disorder and Neuromodulation Unit, Department of Neurology Charité—Universitätsmedizin Berlin GermanyMovement Disorder and Neuromodulation Unit, Department of Neurology Charité—Universitätsmedizin Berlin GermanyDepartment of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing ChinaDepartment of Functional Neurosurgery Beijing Neurosurgical Institute, Capital Medical University Beijing ChinaDepartment of Functional Neurosurgery Beijing Neurosurgical Institute, Capital Medical University Beijing ChinaMovement Disorder and Neuromodulation Unit, Department of Neurology Charité—Universitätsmedizin Berlin GermanyDepartment of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing ChinaMovement Disorder and Neuromodulation Unit, Department of Neurology Charité—Universitätsmedizin Berlin GermanyMovement Disorder and Neuromodulation Unit, Department of Neurology Charité—Universitätsmedizin Berlin GermanyDepartment of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing ChinaABSTRACT Objective Deep brain stimulation offers a unique opportunity to record neural activity of the basal ganglia. While much work in dystonia has focused on the globus pallidus internus, expanding research to investigate subthalamic nucleus (STN) activity in various dystonia types is critical to provide a comprehensive understanding of dystonia pathophysiology. Methods STN and cortex activity were recorded from 17 patients with cervical dystonia (CD), 19 with Meige syndrome, and 9 with generalized dystonia (GD) during the lead externalized period. We investigated local and network oscillatory characteristics, including power, bursts, and coherence. Additionally, we explored the relationship between these features and the severity of dystonic symptoms within each group and conducted a comparative analysis across the different dystonia types. Results Peaks of low‐frequency (4–13 Hz) and beta (14–30 Hz) power were present in the STN of all patients; most of the beta peaks are distributed in the high beta range (20–30 Hz). The CD and GD groups showed longer low‐frequency bursts and greater high beta power in STN than the Meige group. Interestingly, the CD group showed stronger STN‐cortex low‐frequency coherence, while the GD group had stronger STN‐cortex high beta coherence. Combined, low‐frequency and beta features could predict symptom severity with a performance of 73% in the CD group and 82% in the GD group. Interpretation Low‐frequency and high‐beta oscillations are present in the STN across all three types of dystonia. The distinct patterns may be associated with different underlying pathological mechanisms.https://doi.org/10.1002/acn3.70040dystonialocal field potentials (LFPs)subthalamic nucleus (STN) |
| spellingShingle | Zhu Guan‐Yu Yin Zi‐Xiao Chen Ying‐Chuan Timon Merk Thomas Binns Ma Ruo‐Yu Du Ting‐Ting Liu Yu‐Ye Xie Hu‐Tao Shi Lin Yang An‐Chao Meng Fan‐Gang Wolf‐Julian Neumann Andrea A. Kühn Zhang Jian‐Guo Subthalamic Nucleus Oscillatory Characteristics in Meige, Cervical Dystonia and Generalized Dystonia Annals of Clinical and Translational Neurology dystonia local field potentials (LFPs) subthalamic nucleus (STN) |
| title | Subthalamic Nucleus Oscillatory Characteristics in Meige, Cervical Dystonia and Generalized Dystonia |
| title_full | Subthalamic Nucleus Oscillatory Characteristics in Meige, Cervical Dystonia and Generalized Dystonia |
| title_fullStr | Subthalamic Nucleus Oscillatory Characteristics in Meige, Cervical Dystonia and Generalized Dystonia |
| title_full_unstemmed | Subthalamic Nucleus Oscillatory Characteristics in Meige, Cervical Dystonia and Generalized Dystonia |
| title_short | Subthalamic Nucleus Oscillatory Characteristics in Meige, Cervical Dystonia and Generalized Dystonia |
| title_sort | subthalamic nucleus oscillatory characteristics in meige cervical dystonia and generalized dystonia |
| topic | dystonia local field potentials (LFPs) subthalamic nucleus (STN) |
| url | https://doi.org/10.1002/acn3.70040 |
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