Impact of moderate and late preterm birth on neurodevelopment, brain development and respiratory health at school age: protocol for a longitudinal cohort study (LaPrem study)
Introduction Children born moderate to late preterm (MLP, 32–36 weeks’ gestation) account for approximately 85% of all preterm births globally. Compared with children born at term, children born MLP are at increased risk of poor neurodevelopmental outcomes. Despite making up the largest group of pre...
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BMJ Publishing Group
2021-01-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/11/1/e044491.full |
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| author | Alicia J Spittle Peter J Anderson Jeanie Cheong Alice Burnett Sarath Ranganathan Katherine Lee Lex William Doyle Kate Lillian Iona Cameron Deanne Thompson Ross Clark Benjamin Mentiplay |
| author_facet | Alicia J Spittle Peter J Anderson Jeanie Cheong Alice Burnett Sarath Ranganathan Katherine Lee Lex William Doyle Kate Lillian Iona Cameron Deanne Thompson Ross Clark Benjamin Mentiplay |
| author_sort | Alicia J Spittle |
| collection | DOAJ |
| description | Introduction Children born moderate to late preterm (MLP, 32–36 weeks’ gestation) account for approximately 85% of all preterm births globally. Compared with children born at term, children born MLP are at increased risk of poor neurodevelopmental outcomes. Despite making up the largest group of preterm children, developmental outcomes of children born MLP are less well studied than in other preterm groups. This study aimed to (1) compare neurodevelopmental, respiratory health and brain magnetic resonance imaging (MRI) outcomes between children born MLP and term at 9 years of age; (2) examine the differences in brain growth trajectory from infancy to 9 years between children born MLP and term; and in children born MLP; (3) examine the relationship between brain development and neurodevelopment at 9 years; and (4) identify risk factors for poorer outcomes at 9 years.Methods and analysis The ”LaPrem” (Late Preterm MRI Study) study is a longitudinal cohort study of children born MLP and term controls, born at the Royal Women’s Hospital in Melbourne, Australia, between 2010 and 2013. Participants were recruited in the neonatal period and were previously followed up at 2 and 5 years. This 9-year school-age follow-up includes neuropsychology, motor and physical activities, and lung function assessments, as well as brain MRI. Outcomes at 9 years will be compared between birth groups using linear and logistic regressions. Trajectories of brain development will be compared between birth groups using mixed effects models. The relationships between MRI and neurodevelopmental outcomes, as well as other early predictors of poor 9-year outcomes, will be explored using linear and logistic regression.Ethics and dissemination This study was approved by the human research ethics committee at the Royal Children’s Hospital, Melbourne, Australia. Study outcomes will be disseminated through peer-reviewed publications, conference presentations and social media. |
| format | Article |
| id | doaj-art-e3b033f250514f3ba56e6de3d7e20c34 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-e3b033f250514f3ba56e6de3d7e20c342024-11-18T12:45:07ZengBMJ Publishing GroupBMJ Open2044-60552021-01-0111110.1136/bmjopen-2020-044491Impact of moderate and late preterm birth on neurodevelopment, brain development and respiratory health at school age: protocol for a longitudinal cohort study (LaPrem study)Alicia J Spittle0Peter J Anderson1Jeanie Cheong2Alice Burnett3Sarath Ranganathan4Katherine Lee5Lex William Doyle6Kate Lillian Iona Cameron7Deanne Thompson8Ross Clark9Benjamin Mentiplay106 Neonatal Research, The Royal Women`s Hospital, Parkville, Victoria, AustraliaClinical Sciences, Murdoch Children’s Research Institute, Parkville, Victoria, AustraliaClinical Sciences, Murdoch Children’s Research Institute, Parkville, Victoria, AustraliaDepartment of Neonatal Medicine, The Royal Children’s Hospital, Melbourne, Victoria, AustraliaDepartment of Paediatrics, The University of Melbourne, Melbourne, Victoria, AustraliaDepartment of Paediatrics, The University of Melbourne, Melbourne, Victoria, AustraliaDepartment of Paediatrics, The University of Melbourne, Melbourne, Victoria, AustraliaClinical Sciences, Murdoch Children’s Research Institute, Parkville, Victoria, AustraliaClinical Sciences, Murdoch Children’s Research Institute, Parkville, Victoria, AustraliaResearch Health Institute, University of the Sunshine Coast, Sunshine Coast, Queensland, AustraliaLa Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Bundoora, Victoria, AustraliaIntroduction Children born moderate to late preterm (MLP, 32–36 weeks’ gestation) account for approximately 85% of all preterm births globally. Compared with children born at term, children born MLP are at increased risk of poor neurodevelopmental outcomes. Despite making up the largest group of preterm children, developmental outcomes of children born MLP are less well studied than in other preterm groups. This study aimed to (1) compare neurodevelopmental, respiratory health and brain magnetic resonance imaging (MRI) outcomes between children born MLP and term at 9 years of age; (2) examine the differences in brain growth trajectory from infancy to 9 years between children born MLP and term; and in children born MLP; (3) examine the relationship between brain development and neurodevelopment at 9 years; and (4) identify risk factors for poorer outcomes at 9 years.Methods and analysis The ”LaPrem” (Late Preterm MRI Study) study is a longitudinal cohort study of children born MLP and term controls, born at the Royal Women’s Hospital in Melbourne, Australia, between 2010 and 2013. Participants were recruited in the neonatal period and were previously followed up at 2 and 5 years. This 9-year school-age follow-up includes neuropsychology, motor and physical activities, and lung function assessments, as well as brain MRI. Outcomes at 9 years will be compared between birth groups using linear and logistic regressions. Trajectories of brain development will be compared between birth groups using mixed effects models. The relationships between MRI and neurodevelopmental outcomes, as well as other early predictors of poor 9-year outcomes, will be explored using linear and logistic regression.Ethics and dissemination This study was approved by the human research ethics committee at the Royal Children’s Hospital, Melbourne, Australia. Study outcomes will be disseminated through peer-reviewed publications, conference presentations and social media.https://bmjopen.bmj.com/content/11/1/e044491.full |
| spellingShingle | Alicia J Spittle Peter J Anderson Jeanie Cheong Alice Burnett Sarath Ranganathan Katherine Lee Lex William Doyle Kate Lillian Iona Cameron Deanne Thompson Ross Clark Benjamin Mentiplay Impact of moderate and late preterm birth on neurodevelopment, brain development and respiratory health at school age: protocol for a longitudinal cohort study (LaPrem study) BMJ Open |
| title | Impact of moderate and late preterm birth on neurodevelopment, brain development and respiratory health at school age: protocol for a longitudinal cohort study (LaPrem study) |
| title_full | Impact of moderate and late preterm birth on neurodevelopment, brain development and respiratory health at school age: protocol for a longitudinal cohort study (LaPrem study) |
| title_fullStr | Impact of moderate and late preterm birth on neurodevelopment, brain development and respiratory health at school age: protocol for a longitudinal cohort study (LaPrem study) |
| title_full_unstemmed | Impact of moderate and late preterm birth on neurodevelopment, brain development and respiratory health at school age: protocol for a longitudinal cohort study (LaPrem study) |
| title_short | Impact of moderate and late preterm birth on neurodevelopment, brain development and respiratory health at school age: protocol for a longitudinal cohort study (LaPrem study) |
| title_sort | impact of moderate and late preterm birth on neurodevelopment brain development and respiratory health at school age protocol for a longitudinal cohort study laprem study |
| url | https://bmjopen.bmj.com/content/11/1/e044491.full |
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