Clostridial Spores for Cancer Therapy: Targeting Solid Tumour Microenvironment
Solid tumour accounts for 90% of all cancers. The current treatment approach for most solid tumours is surgery, however it is limited to early stage tumours. Other treatment options such as chemotherapy and radiotherapy are non-selective, thus causing damage to both healthy and cancerous tissue. Pas...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2012/862764 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849434790536675328 |
|---|---|
| author | Brittany Umer David Good Jozef Anné Wei Duan Ming Q. Wei |
| author_facet | Brittany Umer David Good Jozef Anné Wei Duan Ming Q. Wei |
| author_sort | Brittany Umer |
| collection | DOAJ |
| description | Solid tumour accounts for 90% of all cancers. The current treatment approach for most solid tumours is surgery, however it is limited to early stage tumours. Other treatment options such as chemotherapy and radiotherapy are non-selective, thus causing damage to both healthy and cancerous tissue. Past research has focused on understanding tumour cells themselves, and conventional wisdom has aimed at targeting these cells directly. Recent research has shifted towards understanding the tumour microenvironment and it’s differences from that of healthy cells/tissues in the body and then to exploit these differences for treatmeat of the tumour. One such approach is utilizing anaerobic bacteria. Several strains of bacteria have been shown to selectively colonize in solid tumours, making them valuable tools for selective tumour targeting and destruction. Amongst them, the anaerobic Clostridium has shown great potential in penetration and colonization of the hypoxic and necrotic areas of the tumour microenvironment, causing significant oncolysis as well as enabling the delivery of therapeutics directly to the tumour in situ. Various strategies utilizing Clostridium are currently being investigated, and represent a novel area of emerging cancer therapy. This review provides an update review of tumour microenvironment as well as summary of the progresses and current status of Clostridial spore-based cancer therapies. |
| format | Article |
| id | doaj-art-e3afd80da86c47d18fc7f7d74393f8bb |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-e3afd80da86c47d18fc7f7d74393f8bb2025-08-20T03:26:31ZengWileyJournal of Toxicology1687-81911687-82052012-01-01201210.1155/2012/862764862764Clostridial Spores for Cancer Therapy: Targeting Solid Tumour MicroenvironmentBrittany Umer0David Good1Jozef Anné2Wei Duan3Ming Q. Wei4School of Medical Science and Griffith Health Institute, Griffith University, Gold Coast Campus, Southport, QLD 4222, AustraliaSchool of Physiotherapy, Australian Catholic University, McAuley Campus, Banyo, QLD 4014, AustraliaRega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, BelgiumSchool of Medicine, Deakin University, Waurn Ponds, VIC 3217, AustraliaSchool of Medical Science and Griffith Health Institute, Griffith University, Gold Coast Campus, Southport, QLD 4222, AustraliaSolid tumour accounts for 90% of all cancers. The current treatment approach for most solid tumours is surgery, however it is limited to early stage tumours. Other treatment options such as chemotherapy and radiotherapy are non-selective, thus causing damage to both healthy and cancerous tissue. Past research has focused on understanding tumour cells themselves, and conventional wisdom has aimed at targeting these cells directly. Recent research has shifted towards understanding the tumour microenvironment and it’s differences from that of healthy cells/tissues in the body and then to exploit these differences for treatmeat of the tumour. One such approach is utilizing anaerobic bacteria. Several strains of bacteria have been shown to selectively colonize in solid tumours, making them valuable tools for selective tumour targeting and destruction. Amongst them, the anaerobic Clostridium has shown great potential in penetration and colonization of the hypoxic and necrotic areas of the tumour microenvironment, causing significant oncolysis as well as enabling the delivery of therapeutics directly to the tumour in situ. Various strategies utilizing Clostridium are currently being investigated, and represent a novel area of emerging cancer therapy. This review provides an update review of tumour microenvironment as well as summary of the progresses and current status of Clostridial spore-based cancer therapies.http://dx.doi.org/10.1155/2012/862764 |
| spellingShingle | Brittany Umer David Good Jozef Anné Wei Duan Ming Q. Wei Clostridial Spores for Cancer Therapy: Targeting Solid Tumour Microenvironment Journal of Toxicology |
| title | Clostridial Spores for Cancer Therapy: Targeting Solid Tumour Microenvironment |
| title_full | Clostridial Spores for Cancer Therapy: Targeting Solid Tumour Microenvironment |
| title_fullStr | Clostridial Spores for Cancer Therapy: Targeting Solid Tumour Microenvironment |
| title_full_unstemmed | Clostridial Spores for Cancer Therapy: Targeting Solid Tumour Microenvironment |
| title_short | Clostridial Spores for Cancer Therapy: Targeting Solid Tumour Microenvironment |
| title_sort | clostridial spores for cancer therapy targeting solid tumour microenvironment |
| url | http://dx.doi.org/10.1155/2012/862764 |
| work_keys_str_mv | AT brittanyumer clostridialsporesforcancertherapytargetingsolidtumourmicroenvironment AT davidgood clostridialsporesforcancertherapytargetingsolidtumourmicroenvironment AT jozefanne clostridialsporesforcancertherapytargetingsolidtumourmicroenvironment AT weiduan clostridialsporesforcancertherapytargetingsolidtumourmicroenvironment AT mingqwei clostridialsporesforcancertherapytargetingsolidtumourmicroenvironment |