An improved reference library and method for accurate cell-type deconvolution of bulk-tissue miRNA data

An improved reference library and method for accurate cell-type deconvolution of bulk-tissue miRNA data

Abstract MicroRNAs (miRNAs) play key roles in development and disease, and have great biomarker potential. However, because miRNA expression is highly cell-type specific, identifying miRNA biomarkers from complex tissues is hampered by the underlying cell-type heterogeneity. Due to that current sing...

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Bibliographic Details
Main Authors: Shaoying Zhu, Hui Yang, Jun Liu, Qingsheng Fu, Wei Huang, Qi Chen, Andrew E. Teschendorff, Yungang He, Zhen Yang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60521-x
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