Adipokines regulate the development and progression of MASLD through organellar oxidative stress
The prevalence of metabolic dysfunction–associated steatotic liver disease (MASLD), which is increasingly being recognized as a leading cause of chronic liver pathology globally, is increasing. The pathophysiological underpinnings of its progression, which is currently under active investigation, in...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health/LWW
2025-02-01
|
| Series: | Hepatology Communications |
| Online Access: | http://journals.lww.com/10.1097/HC9.0000000000000639 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832540496930537472 |
|---|---|
| author | Ke Zhao Heng Zhang Wenyu Ding Xiaoshuai Yu Yanli Hou Xihong Liu Xinhua Li Xiaolei Wang |
| author_facet | Ke Zhao Heng Zhang Wenyu Ding Xiaoshuai Yu Yanli Hou Xihong Liu Xinhua Li Xiaolei Wang |
| author_sort | Ke Zhao |
| collection | DOAJ |
| description | The prevalence of metabolic dysfunction–associated steatotic liver disease (MASLD), which is increasingly being recognized as a leading cause of chronic liver pathology globally, is increasing. The pathophysiological underpinnings of its progression, which is currently under active investigation, involve oxidative stress. Human adipose tissue, an integral endocrine organ, secretes an array of adipokines that are modulated by dietary patterns and lifestyle choices. These adipokines intricately orchestrate regulatory pathways that impact glucose and lipid metabolism, oxidative stress, and mitochondrial function, thereby influencing the evolution of hepatic steatosis and progression to metabolic dysfunction–associated steatohepatitis (MASH). This review examines recent data, underscoring the critical interplay of oxidative stress, reactive oxygen species, and redox signaling in adipokine-mediated mechanisms. The role of various adipokines in regulating the onset and progression of MASLD/MASH through mitochondrial dysfunction and endoplasmic reticulum stress and the underlying mechanisms are discussed. Due to the emerging correlation between adipokines and the development of MASLD positions, these adipokines are potential targets for the development of innovative therapeutic interventions for MASLD management. A comprehensive understanding of the pathogenesis of MASLD/MASH is instrumental for identifying therapies for MASH. |
| format | Article |
| id | doaj-art-e3ade07f830549f5bac796eaa42a6dec |
| institution | Kabale University |
| issn | 2471-254X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Hepatology Communications |
| spelling | doaj-art-e3ade07f830549f5bac796eaa42a6dec2025-02-05T02:11:00ZengWolters Kluwer Health/LWWHepatology Communications2471-254X2025-02-019210.1097/HC9.0000000000000639HC90000000000000639Adipokines regulate the development and progression of MASLD through organellar oxidative stressKe Zhao0Heng Zhang1Wenyu Ding2Xiaoshuai Yu3Yanli Hou4Xihong Liu5Xinhua Li6Xiaolei Wang7 1 Central laboratory, Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China 1 Central laboratory, Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China 1 Central laboratory, Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China 1 Central laboratory, Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China 1 Central laboratory, Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China 5 Department of Pathology, The Fourth People’s Hospital of Jinan, Jinan, Shandong, China 1 Central laboratory, Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China 1 Central laboratory, Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaThe prevalence of metabolic dysfunction–associated steatotic liver disease (MASLD), which is increasingly being recognized as a leading cause of chronic liver pathology globally, is increasing. The pathophysiological underpinnings of its progression, which is currently under active investigation, involve oxidative stress. Human adipose tissue, an integral endocrine organ, secretes an array of adipokines that are modulated by dietary patterns and lifestyle choices. These adipokines intricately orchestrate regulatory pathways that impact glucose and lipid metabolism, oxidative stress, and mitochondrial function, thereby influencing the evolution of hepatic steatosis and progression to metabolic dysfunction–associated steatohepatitis (MASH). This review examines recent data, underscoring the critical interplay of oxidative stress, reactive oxygen species, and redox signaling in adipokine-mediated mechanisms. The role of various adipokines in regulating the onset and progression of MASLD/MASH through mitochondrial dysfunction and endoplasmic reticulum stress and the underlying mechanisms are discussed. Due to the emerging correlation between adipokines and the development of MASLD positions, these adipokines are potential targets for the development of innovative therapeutic interventions for MASLD management. A comprehensive understanding of the pathogenesis of MASLD/MASH is instrumental for identifying therapies for MASH.http://journals.lww.com/10.1097/HC9.0000000000000639 |
| spellingShingle | Ke Zhao Heng Zhang Wenyu Ding Xiaoshuai Yu Yanli Hou Xihong Liu Xinhua Li Xiaolei Wang Adipokines regulate the development and progression of MASLD through organellar oxidative stress Hepatology Communications |
| title | Adipokines regulate the development and progression of MASLD through organellar oxidative stress |
| title_full | Adipokines regulate the development and progression of MASLD through organellar oxidative stress |
| title_fullStr | Adipokines regulate the development and progression of MASLD through organellar oxidative stress |
| title_full_unstemmed | Adipokines regulate the development and progression of MASLD through organellar oxidative stress |
| title_short | Adipokines regulate the development and progression of MASLD through organellar oxidative stress |
| title_sort | adipokines regulate the development and progression of masld through organellar oxidative stress |
| url | http://journals.lww.com/10.1097/HC9.0000000000000639 |
| work_keys_str_mv | AT kezhao adipokinesregulatethedevelopmentandprogressionofmasldthroughorganellaroxidativestress AT hengzhang adipokinesregulatethedevelopmentandprogressionofmasldthroughorganellaroxidativestress AT wenyuding adipokinesregulatethedevelopmentandprogressionofmasldthroughorganellaroxidativestress AT xiaoshuaiyu adipokinesregulatethedevelopmentandprogressionofmasldthroughorganellaroxidativestress AT yanlihou adipokinesregulatethedevelopmentandprogressionofmasldthroughorganellaroxidativestress AT xihongliu adipokinesregulatethedevelopmentandprogressionofmasldthroughorganellaroxidativestress AT xinhuali adipokinesregulatethedevelopmentandprogressionofmasldthroughorganellaroxidativestress AT xiaoleiwang adipokinesregulatethedevelopmentandprogressionofmasldthroughorganellaroxidativestress |