Effect of ritodrine tocolysis on fetal cardiac output distribution to the placenta
Background: Adequate placental perfusion is important for fetal development and well-being, but the effect of tocolysis on placental perfusion is unclear. The aim of this study was to evaluate changes in fetal cardiac output distribution to the placenta following ritodrine tocolysis. Methods: This r...
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| Format: | Article |
| Language: | English |
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IMR Press
2021-10-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/48/5/10.31083/j.ceog4805181 |
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| author | Ryuichi Shimaoka Tomomi Shiga Ken-ichirou Morishige |
| author_facet | Ryuichi Shimaoka Tomomi Shiga Ken-ichirou Morishige |
| author_sort | Ryuichi Shimaoka |
| collection | DOAJ |
| description | Background: Adequate placental perfusion is important for fetal development and well-being, but the effect of tocolysis on placental perfusion is unclear. The aim of this study was to evaluate changes in fetal cardiac output distribution to the placenta following ritodrine tocolysis. Methods: This retrospective study involved 244 ultrasound findings in 142 singleton cases of appropriate for gestational age fetuses. The fetal cardiac output distribution to the placenta was defined and calculated as the percentage of umbilical vein flow volume (UVFV) based on the combined cardiac output (CCO). Ultrasound findings of 28 patients in the ritodrine group and 114 patients in the control group were compared using the unpaired t-test and Mann-Whitney U-test. Results: The CCO and UVFV increased as gestation progressed. On the other hand, distribution to the placenta was constant at approximately 15% from 28 to 35 weeks of gestation. Compared with the control group, the ritodrine group showed a significant increase in fetal heart rate, and the CCO also increased. The increase in UVFV in the ritodrine group was attributed to a significant increase in both the umbilical vessel diameter and blood flow velocity. As a result, distribution to the placenta in the ritodrine group was constant at about 20% and had a 5% increase at each week of gestation compared to the control group. Conclusions: To conclude, ritodrine tocolysis increased the fetal cardiac output distribution to the placenta. Additional research is required to determine whether tocolysis improves the placental perfusion in fetal growth restriction due to reduced placental perfusion. |
| format | Article |
| id | doaj-art-e3a0418ec7ba45e9bc15e7c65eb787bf |
| institution | Kabale University |
| issn | 0390-6663 |
| language | English |
| publishDate | 2021-10-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-e3a0418ec7ba45e9bc15e7c65eb787bf2025-08-20T03:48:32ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632021-10-014851126113110.31083/j.ceog4805181S0390-6663(21)00020-8Effect of ritodrine tocolysis on fetal cardiac output distribution to the placentaRyuichi Shimaoka0Tomomi Shiga1Ken-ichirou Morishige2Department of Obstetrics & Gynecology, Gifu University Graduate School of Medicine, 1-1, Yanagido, Gifu-shi, Gifu-prefecture, 501-1194 Gifu, JapanDepartment of Obstetrics & Gynecology, Gifu University Graduate School of Medicine, 1-1, Yanagido, Gifu-shi, Gifu-prefecture, 501-1194 Gifu, JapanDepartment of Obstetrics & Gynecology, Gifu University Graduate School of Medicine, 1-1, Yanagido, Gifu-shi, Gifu-prefecture, 501-1194 Gifu, JapanBackground: Adequate placental perfusion is important for fetal development and well-being, but the effect of tocolysis on placental perfusion is unclear. The aim of this study was to evaluate changes in fetal cardiac output distribution to the placenta following ritodrine tocolysis. Methods: This retrospective study involved 244 ultrasound findings in 142 singleton cases of appropriate for gestational age fetuses. The fetal cardiac output distribution to the placenta was defined and calculated as the percentage of umbilical vein flow volume (UVFV) based on the combined cardiac output (CCO). Ultrasound findings of 28 patients in the ritodrine group and 114 patients in the control group were compared using the unpaired t-test and Mann-Whitney U-test. Results: The CCO and UVFV increased as gestation progressed. On the other hand, distribution to the placenta was constant at approximately 15% from 28 to 35 weeks of gestation. Compared with the control group, the ritodrine group showed a significant increase in fetal heart rate, and the CCO also increased. The increase in UVFV in the ritodrine group was attributed to a significant increase in both the umbilical vessel diameter and blood flow velocity. As a result, distribution to the placenta in the ritodrine group was constant at about 20% and had a 5% increase at each week of gestation compared to the control group. Conclusions: To conclude, ritodrine tocolysis increased the fetal cardiac output distribution to the placenta. Additional research is required to determine whether tocolysis improves the placental perfusion in fetal growth restriction due to reduced placental perfusion.https://www.imrpress.com/journal/CEOG/48/5/10.31083/j.ceog4805181distribution to the placentadoppler ultrasoundfetal cardiac outputritodrineumbilical vein flow volume |
| spellingShingle | Ryuichi Shimaoka Tomomi Shiga Ken-ichirou Morishige Effect of ritodrine tocolysis on fetal cardiac output distribution to the placenta Clinical and Experimental Obstetrics & Gynecology distribution to the placenta doppler ultrasound fetal cardiac output ritodrine umbilical vein flow volume |
| title | Effect of ritodrine tocolysis on fetal cardiac output distribution to the placenta |
| title_full | Effect of ritodrine tocolysis on fetal cardiac output distribution to the placenta |
| title_fullStr | Effect of ritodrine tocolysis on fetal cardiac output distribution to the placenta |
| title_full_unstemmed | Effect of ritodrine tocolysis on fetal cardiac output distribution to the placenta |
| title_short | Effect of ritodrine tocolysis on fetal cardiac output distribution to the placenta |
| title_sort | effect of ritodrine tocolysis on fetal cardiac output distribution to the placenta |
| topic | distribution to the placenta doppler ultrasound fetal cardiac output ritodrine umbilical vein flow volume |
| url | https://www.imrpress.com/journal/CEOG/48/5/10.31083/j.ceog4805181 |
| work_keys_str_mv | AT ryuichishimaoka effectofritodrinetocolysisonfetalcardiacoutputdistributiontotheplacenta AT tomomishiga effectofritodrinetocolysisonfetalcardiacoutputdistributiontotheplacenta AT kenichiroumorishige effectofritodrinetocolysisonfetalcardiacoutputdistributiontotheplacenta |