Unraveling HPV-associated cancer complexity: From molecular insights to innovative therapies
Human papillomavirus (HPV) contributes to a high global incidence of sexually transmitted infections, predominantly associated with cervical cancer, as well as head and neck, penile, anal, vaginal, and vulvar cancers. Despite efforts through improved screening and HPV vaccination campaigns, challeng...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025008175 |
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| author | Tara Chand Ashwini Kumar Dubey Gauri Misra |
| author_facet | Tara Chand Ashwini Kumar Dubey Gauri Misra |
| author_sort | Tara Chand |
| collection | DOAJ |
| description | Human papillomavirus (HPV) contributes to a high global incidence of sexually transmitted infections, predominantly associated with cervical cancer, as well as head and neck, penile, anal, vaginal, and vulvar cancers. Despite efforts through improved screening and HPV vaccination campaigns, challenges persist, influencing the frequency of HPV-related malignancies. Collaborative scientific endeavors strive to pioneer groundbreaking approaches, aiming to alleviate the adverse consequences of HPV-related malignancies on individuals and communities.The present review is focused on exhaustively covering HPV-associated cancers, particularly cervical cancer. This study highlights the initiation, progression, immune invasion, and treatment strategies of HPV-associated cancers. The role of viral oncoproteins E6 and E7 responsible for immune evasion and subsequent latent infection is also elaborated. The article also sheds light on the pivotal role of HPV vaccination in averting high-risk HPV infections and associated cancers. The scope of this review encompasses HPV-associated cancer epidemiology, regional disparities, and the distinctive challenges faced in the context of India. This will be a value addition to the knowledge repertoire beneficial for creating awareness and designing health policies. |
| format | Article |
| id | doaj-art-e39fb124e7e94a389c6eabcd60df007c |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-e39fb124e7e94a389c6eabcd60df007c2025-02-09T05:00:40ZengElsevierHeliyon2405-84402025-02-01113e42437Unraveling HPV-associated cancer complexity: From molecular insights to innovative therapiesTara Chand0Ashwini Kumar Dubey1Gauri Misra2National Institute of Biologicals (Ministry of Health & Family Welfare, Government of India), A-32, Sector-62, Noida, 201309, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, 201 002, IndiaNational Institute of Biologicals (Ministry of Health & Family Welfare, Government of India), A-32, Sector-62, Noida, 201309, IndiaNational Institute of Biologicals (Ministry of Health & Family Welfare, Government of India), A-32, Sector-62, Noida, 201309, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, 201 002, India; Corresponding author. Molecular Diagnostics and COVID-19 Kit Testing Laboratory, National Institute of Biologicals, (Ministry of Health & Family Welfare), Government of India, Noida, 201309, India.kamgauri@gmail.comHuman papillomavirus (HPV) contributes to a high global incidence of sexually transmitted infections, predominantly associated with cervical cancer, as well as head and neck, penile, anal, vaginal, and vulvar cancers. Despite efforts through improved screening and HPV vaccination campaigns, challenges persist, influencing the frequency of HPV-related malignancies. Collaborative scientific endeavors strive to pioneer groundbreaking approaches, aiming to alleviate the adverse consequences of HPV-related malignancies on individuals and communities.The present review is focused on exhaustively covering HPV-associated cancers, particularly cervical cancer. This study highlights the initiation, progression, immune invasion, and treatment strategies of HPV-associated cancers. The role of viral oncoproteins E6 and E7 responsible for immune evasion and subsequent latent infection is also elaborated. The article also sheds light on the pivotal role of HPV vaccination in averting high-risk HPV infections and associated cancers. The scope of this review encompasses HPV-associated cancer epidemiology, regional disparities, and the distinctive challenges faced in the context of India. This will be a value addition to the knowledge repertoire beneficial for creating awareness and designing health policies.http://www.sciencedirect.com/science/article/pii/S2405844025008175Cervical cancerHuman papillomavirusHPV vaccinationLatent infectionImmuno-evasion |
| spellingShingle | Tara Chand Ashwini Kumar Dubey Gauri Misra Unraveling HPV-associated cancer complexity: From molecular insights to innovative therapies Heliyon Cervical cancer Human papillomavirus HPV vaccination Latent infection Immuno-evasion |
| title | Unraveling HPV-associated cancer complexity: From molecular insights to innovative therapies |
| title_full | Unraveling HPV-associated cancer complexity: From molecular insights to innovative therapies |
| title_fullStr | Unraveling HPV-associated cancer complexity: From molecular insights to innovative therapies |
| title_full_unstemmed | Unraveling HPV-associated cancer complexity: From molecular insights to innovative therapies |
| title_short | Unraveling HPV-associated cancer complexity: From molecular insights to innovative therapies |
| title_sort | unraveling hpv associated cancer complexity from molecular insights to innovative therapies |
| topic | Cervical cancer Human papillomavirus HPV vaccination Latent infection Immuno-evasion |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025008175 |
| work_keys_str_mv | AT tarachand unravelinghpvassociatedcancercomplexityfrommolecularinsightstoinnovativetherapies AT ashwinikumardubey unravelinghpvassociatedcancercomplexityfrommolecularinsightstoinnovativetherapies AT gaurimisra unravelinghpvassociatedcancercomplexityfrommolecularinsightstoinnovativetherapies |