The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy
Abstract KRAS is one of the most mutated genes, driving alternations in metabolic pathways that include enhanced nutrient uptaking, increased glycolysis, elevated glutaminolysis, and heightened synthesis of fatty acids and nucleotides. However, the beyond mechanisms of KRAS-modulated cancer metaboli...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Molecular Cancer |
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| Online Access: | https://doi.org/10.1186/s12943-024-02218-1 |
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| author | Qinglong Ma Wenyang Zhang Kongming Wu Lei Shi |
| author_facet | Qinglong Ma Wenyang Zhang Kongming Wu Lei Shi |
| author_sort | Qinglong Ma |
| collection | DOAJ |
| description | Abstract KRAS is one of the most mutated genes, driving alternations in metabolic pathways that include enhanced nutrient uptaking, increased glycolysis, elevated glutaminolysis, and heightened synthesis of fatty acids and nucleotides. However, the beyond mechanisms of KRAS-modulated cancer metabolisms remain incompletely understood. In this review, we aim to summarize current knowledge on KRAS-related metabolic alterations in cancer cells and explore the prevalence and significance of KRAS mutation in shaping the tumor microenvironment and influencing epigenetic modification via various molecular activities. Given that cancer cells rely on these metabolic changes to sustain cell growth and survival, targeting these processes may represent a promising therapeutic strategy for KRAS-driven cancers. |
| format | Article |
| id | doaj-art-e39ea3a6a77440c1b3384cca04f51b10 |
| institution | Kabale University |
| issn | 1476-4598 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj-art-e39ea3a6a77440c1b3384cca04f51b102025-01-19T12:12:36ZengBMCMolecular Cancer1476-45982025-01-0124111810.1186/s12943-024-02218-1The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapyQinglong Ma0Wenyang Zhang1Kongming Wu2Lei Shi3RNA Oncology Group, School of Public Health, Lanzhou UniversityRNA Oncology Group, School of Public Health, Lanzhou UniversityCancer Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical UniversityRNA Oncology Group, School of Public Health, Lanzhou UniversityAbstract KRAS is one of the most mutated genes, driving alternations in metabolic pathways that include enhanced nutrient uptaking, increased glycolysis, elevated glutaminolysis, and heightened synthesis of fatty acids and nucleotides. However, the beyond mechanisms of KRAS-modulated cancer metabolisms remain incompletely understood. In this review, we aim to summarize current knowledge on KRAS-related metabolic alterations in cancer cells and explore the prevalence and significance of KRAS mutation in shaping the tumor microenvironment and influencing epigenetic modification via various molecular activities. Given that cancer cells rely on these metabolic changes to sustain cell growth and survival, targeting these processes may represent a promising therapeutic strategy for KRAS-driven cancers.https://doi.org/10.1186/s12943-024-02218-1KRASCancer metabolismTumor microenvironmentEpigenetic modification |
| spellingShingle | Qinglong Ma Wenyang Zhang Kongming Wu Lei Shi The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy Molecular Cancer KRAS Cancer metabolism Tumor microenvironment Epigenetic modification |
| title | The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy |
| title_full | The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy |
| title_fullStr | The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy |
| title_full_unstemmed | The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy |
| title_short | The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy |
| title_sort | roles of kras in cancer metabolism tumor microenvironment and clinical therapy |
| topic | KRAS Cancer metabolism Tumor microenvironment Epigenetic modification |
| url | https://doi.org/10.1186/s12943-024-02218-1 |
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