Impact of a multi-strain L. crispatus-based vaginal synbiotic on the vaginal microbiome: a randomized placebo-controlled trial
Abstract A clinical trial of a multi-strain vaginal synbiotic (NCT05659745, registered 12/19/2022 at clinicaltrials.gov) led to an optimal vaginal microbiome dominated by L. crispatus (CST I). The synbiotic led to a significant increase in L. crispatus compared to placebo (p < 0.05), and conversi...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
|
| Series: | npj Biofilms and Microbiomes |
| Online Access: | https://doi.org/10.1038/s41522-025-00788-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849237725539991552 |
|---|---|
| author | Jacques Ravel Sheri Simmons Eleni Greenwood Jaswa Sara Gottfried Miriam Greene Susan Kellogg-Spadt Dirk Gevers Diane M. Harper |
| author_facet | Jacques Ravel Sheri Simmons Eleni Greenwood Jaswa Sara Gottfried Miriam Greene Susan Kellogg-Spadt Dirk Gevers Diane M. Harper |
| author_sort | Jacques Ravel |
| collection | DOAJ |
| description | Abstract A clinical trial of a multi-strain vaginal synbiotic (NCT05659745, registered 12/19/2022 at clinicaltrials.gov) led to an optimal vaginal microbiome dominated by L. crispatus (CST I). The synbiotic led to a significant increase in L. crispatus compared to placebo (p < 0.05), and conversion to CST I was significantly higher with the vaginal synbiotic than with placebo (90 vs 11%; p < 0.002). Mechanistically, the synbiotic reduced Gardnerella vaginalis and Candida, clinically important microbes. |
| format | Article |
| id | doaj-art-e39c04201fd541bb9c2d9fb4e75501ab |
| institution | Kabale University |
| issn | 2055-5008 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biofilms and Microbiomes |
| spelling | doaj-art-e39c04201fd541bb9c2d9fb4e75501ab2025-08-20T04:01:52ZengNature Portfolionpj Biofilms and Microbiomes2055-50082025-08-011111510.1038/s41522-025-00788-6Impact of a multi-strain L. crispatus-based vaginal synbiotic on the vaginal microbiome: a randomized placebo-controlled trialJacques Ravel0Sheri Simmons1Eleni Greenwood Jaswa2Sara Gottfried3Miriam Greene4Susan Kellogg-Spadt5Dirk Gevers6Diane M. Harper7Center for Advanced Microbiome Research and Innovation, Institute for Genome Sciences and Department of Microbiology & Immunology, University of Maryland, School of MedicineSeed HealthDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of CaliforniaDepartment of Integrative Medicine & Nutritional Sciences, Thomas Jefferson UniversityDepartment of Obstetrics & Gynecology, NYU Grossman School of MedicineDepartment of Obstetrics & Gynecology, Drexel University College of MedicineSeed HealthDepartments of Family Medicine, Obstetrics & Gynecology, and Women’s & Gender Studies, University of MichiganAbstract A clinical trial of a multi-strain vaginal synbiotic (NCT05659745, registered 12/19/2022 at clinicaltrials.gov) led to an optimal vaginal microbiome dominated by L. crispatus (CST I). The synbiotic led to a significant increase in L. crispatus compared to placebo (p < 0.05), and conversion to CST I was significantly higher with the vaginal synbiotic than with placebo (90 vs 11%; p < 0.002). Mechanistically, the synbiotic reduced Gardnerella vaginalis and Candida, clinically important microbes.https://doi.org/10.1038/s41522-025-00788-6 |
| spellingShingle | Jacques Ravel Sheri Simmons Eleni Greenwood Jaswa Sara Gottfried Miriam Greene Susan Kellogg-Spadt Dirk Gevers Diane M. Harper Impact of a multi-strain L. crispatus-based vaginal synbiotic on the vaginal microbiome: a randomized placebo-controlled trial npj Biofilms and Microbiomes |
| title | Impact of a multi-strain L. crispatus-based vaginal synbiotic on the vaginal microbiome: a randomized placebo-controlled trial |
| title_full | Impact of a multi-strain L. crispatus-based vaginal synbiotic on the vaginal microbiome: a randomized placebo-controlled trial |
| title_fullStr | Impact of a multi-strain L. crispatus-based vaginal synbiotic on the vaginal microbiome: a randomized placebo-controlled trial |
| title_full_unstemmed | Impact of a multi-strain L. crispatus-based vaginal synbiotic on the vaginal microbiome: a randomized placebo-controlled trial |
| title_short | Impact of a multi-strain L. crispatus-based vaginal synbiotic on the vaginal microbiome: a randomized placebo-controlled trial |
| title_sort | impact of a multi strain l crispatus based vaginal synbiotic on the vaginal microbiome a randomized placebo controlled trial |
| url | https://doi.org/10.1038/s41522-025-00788-6 |
| work_keys_str_mv | AT jacquesravel impactofamultistrainlcrispatusbasedvaginalsynbioticonthevaginalmicrobiomearandomizedplacebocontrolledtrial AT sherisimmons impactofamultistrainlcrispatusbasedvaginalsynbioticonthevaginalmicrobiomearandomizedplacebocontrolledtrial AT elenigreenwoodjaswa impactofamultistrainlcrispatusbasedvaginalsynbioticonthevaginalmicrobiomearandomizedplacebocontrolledtrial AT saragottfried impactofamultistrainlcrispatusbasedvaginalsynbioticonthevaginalmicrobiomearandomizedplacebocontrolledtrial AT miriamgreene impactofamultistrainlcrispatusbasedvaginalsynbioticonthevaginalmicrobiomearandomizedplacebocontrolledtrial AT susankelloggspadt impactofamultistrainlcrispatusbasedvaginalsynbioticonthevaginalmicrobiomearandomizedplacebocontrolledtrial AT dirkgevers impactofamultistrainlcrispatusbasedvaginalsynbioticonthevaginalmicrobiomearandomizedplacebocontrolledtrial AT dianemharper impactofamultistrainlcrispatusbasedvaginalsynbioticonthevaginalmicrobiomearandomizedplacebocontrolledtrial |