Health benefits of medicinal plant natural products via microbiota-mediated different gut axes
This review examines the multifaceted roles of medicinal plant natural products in influencing gut microbiota and their subsequent impact on various organ systems through established gut axes, including the gut-brain, gut-liver, gut-heart, gut-lung, and gut-kidney axes. Medicinal plant natural produ...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825001550 |
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| author | Xiang Li Yufan Liu Ning Liu Hanning Wu Kexin Cong Linnan Duan Tianli Chen Jie Zhang |
| author_facet | Xiang Li Yufan Liu Ning Liu Hanning Wu Kexin Cong Linnan Duan Tianli Chen Jie Zhang |
| author_sort | Xiang Li |
| collection | DOAJ |
| description | This review examines the multifaceted roles of medicinal plant natural products in influencing gut microbiota and their subsequent impact on various organ systems through established gut axes, including the gut-brain, gut-liver, gut-heart, gut-lung, and gut-kidney axes. Medicinal plant natural products have exhibited diverse pharmacological activities, including modulation of microbiota composition, enhancement of metabolic processes, and alleviation of inflammation and oxidative stress. Evidence suggests that these components can ameliorate conditions such as neurological disorders, metabolic syndrome, and chronic kidney disease by restoring microbial balance and improving gut barrier integrity. Furthermore, the review highlights the potential of medicinal plant natural products to foster beneficial microbial communities and improve gut health, which may lead to reduced disease severity and inflammation. By comprehensively analyzing current literature, this review provides a foundation for future research aim at exploring the therapeutic applications of medicinal plant natural products in disease prevention and treatment. The findings underscore the need for further studies to elucidate the underlying mechanisms of action and validate the clinical efficacy of medicinal plant natural products in managing chronic conditions through gut microbiota modulation. |
| format | Article |
| id | doaj-art-e39a523618ec40bfb1e2bd91b0d1d291 |
| institution | OA Journals |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-e39a523618ec40bfb1e2bd91b0d1d2912025-08-20T02:30:14ZengElsevierPharmacological Research1096-11862025-05-0121510773010.1016/j.phrs.2025.107730Health benefits of medicinal plant natural products via microbiota-mediated different gut axesXiang Li0Yufan Liu1Ning Liu2Hanning Wu3Kexin Cong4Linnan Duan5Tianli Chen6Jie Zhang7Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun 130021, ChinaDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun 130021, ChinaDepartment of The Second Section Office of Breast Tumor, Jilin Cancer Hospital, Changchun 130000, ChinaDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun 130021, ChinaDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun 130021, ChinaDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun 130021, ChinaChangchun University of Chinese Medicine, Changchun 130000, China; Corresponding authors.College of Food Science and Engineering, Jilin University, Changchun 130062, China; Corresponding authors.This review examines the multifaceted roles of medicinal plant natural products in influencing gut microbiota and their subsequent impact on various organ systems through established gut axes, including the gut-brain, gut-liver, gut-heart, gut-lung, and gut-kidney axes. Medicinal plant natural products have exhibited diverse pharmacological activities, including modulation of microbiota composition, enhancement of metabolic processes, and alleviation of inflammation and oxidative stress. Evidence suggests that these components can ameliorate conditions such as neurological disorders, metabolic syndrome, and chronic kidney disease by restoring microbial balance and improving gut barrier integrity. Furthermore, the review highlights the potential of medicinal plant natural products to foster beneficial microbial communities and improve gut health, which may lead to reduced disease severity and inflammation. By comprehensively analyzing current literature, this review provides a foundation for future research aim at exploring the therapeutic applications of medicinal plant natural products in disease prevention and treatment. The findings underscore the need for further studies to elucidate the underlying mechanisms of action and validate the clinical efficacy of medicinal plant natural products in managing chronic conditions through gut microbiota modulation.http://www.sciencedirect.com/science/article/pii/S1043661825001550Medicinal plantNatural productsGut microbiotaHealth benefits |
| spellingShingle | Xiang Li Yufan Liu Ning Liu Hanning Wu Kexin Cong Linnan Duan Tianli Chen Jie Zhang Health benefits of medicinal plant natural products via microbiota-mediated different gut axes Pharmacological Research Medicinal plant Natural products Gut microbiota Health benefits |
| title | Health benefits of medicinal plant natural products via microbiota-mediated different gut axes |
| title_full | Health benefits of medicinal plant natural products via microbiota-mediated different gut axes |
| title_fullStr | Health benefits of medicinal plant natural products via microbiota-mediated different gut axes |
| title_full_unstemmed | Health benefits of medicinal plant natural products via microbiota-mediated different gut axes |
| title_short | Health benefits of medicinal plant natural products via microbiota-mediated different gut axes |
| title_sort | health benefits of medicinal plant natural products via microbiota mediated different gut axes |
| topic | Medicinal plant Natural products Gut microbiota Health benefits |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825001550 |
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