Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate.

Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate.

Several lines of evidence suggest that genome-wide association studies (GWAS) have the potential to explain more of the "missing heritability" of common complex phenotypes. However, reliable methods to identify a larger proportion of single nucleotide polymorphisms (SNPs) that impact disea...

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Main Authors: Ole A Andreassen, Wesley K Thompson, Andrew J Schork, Stephan Ripke, Morten Mattingsdal, John R Kelsoe, Kenneth S Kendler, Michael C O'Donovan, Dan Rujescu, Thomas Werge, Pamela Sklar, Psychiatric Genomics Consortium (PGC), Bipolar Disorder and Schizophrenia Working Groups, J Cooper Roddey, Chi-Hua Chen, Linda McEvoy, Rahul S Desikan, Srdjan Djurovic, Anders M Dale
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-04-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003455&type=printable
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