H3K79me3T80ph is a Novel Histone Dual Modification and a Mitotic Indicator in Melanoma
The current study characterizes the mitosis-associated histone dual modification on the core of histone H3: trimethylation of histone H3 lysine 79 and simultaneous phosphorylation of H3 threonine 80 (H3K79me3T80ph). Through the use of protein and microscopy-based techniques, we find that H3K79me3T80...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Skin Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/823534 |
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| _version_ | 1832563054036910080 |
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| author | Danielle R. Martinez Hunter W. Richards Qiushi Lin Carlos A. Torres-Cabala Victor G. Prieto Jonathan L. Curry Estela E. Medrano |
| author_facet | Danielle R. Martinez Hunter W. Richards Qiushi Lin Carlos A. Torres-Cabala Victor G. Prieto Jonathan L. Curry Estela E. Medrano |
| author_sort | Danielle R. Martinez |
| collection | DOAJ |
| description | The current study characterizes the mitosis-associated histone dual modification on the core of histone H3: trimethylation of histone H3 lysine 79 and simultaneous phosphorylation of H3 threonine 80 (H3K79me3T80ph). Through the use of protein and microscopy-based techniques, we find that H3K79me3T80ph shares a similar spatial and temporal regulation as H3S10ph but additionally requires methyltransferase activity. In addition, we find that Aurora kinase activity is necessary for the catalysis of H3K79me3T80ph in vivo. Finally, our analysis of H3K79me3T80ph using a tissue microarray indicates that H3K79me3T80ph marks a subset of primary cutaneous melanomas with metastatic potential indicating that H3K79me3T80ph may identify a subset of invasive melanomas with a more aggressive clinical behaviour. |
| format | Article |
| id | doaj-art-e398d6814f7349b1b8552c96ca0218e2 |
| institution | Kabale University |
| issn | 2090-2905 2090-2913 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Skin Cancer |
| spelling | doaj-art-e398d6814f7349b1b8552c96ca0218e22025-02-03T01:21:09ZengWileyJournal of Skin Cancer2090-29052090-29132012-01-01201210.1155/2012/823534823534H3K79me3T80ph is a Novel Histone Dual Modification and a Mitotic Indicator in MelanomaDanielle R. Martinez0Hunter W. Richards1Qiushi Lin2Carlos A. Torres-Cabala3Victor G. Prieto4Jonathan L. Curry5Estela E. Medrano6Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USAHuffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USAHuffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USADepartment of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USADepartment of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USADepartment of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USAHuffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USAThe current study characterizes the mitosis-associated histone dual modification on the core of histone H3: trimethylation of histone H3 lysine 79 and simultaneous phosphorylation of H3 threonine 80 (H3K79me3T80ph). Through the use of protein and microscopy-based techniques, we find that H3K79me3T80ph shares a similar spatial and temporal regulation as H3S10ph but additionally requires methyltransferase activity. In addition, we find that Aurora kinase activity is necessary for the catalysis of H3K79me3T80ph in vivo. Finally, our analysis of H3K79me3T80ph using a tissue microarray indicates that H3K79me3T80ph marks a subset of primary cutaneous melanomas with metastatic potential indicating that H3K79me3T80ph may identify a subset of invasive melanomas with a more aggressive clinical behaviour.http://dx.doi.org/10.1155/2012/823534 |
| spellingShingle | Danielle R. Martinez Hunter W. Richards Qiushi Lin Carlos A. Torres-Cabala Victor G. Prieto Jonathan L. Curry Estela E. Medrano H3K79me3T80ph is a Novel Histone Dual Modification and a Mitotic Indicator in Melanoma Journal of Skin Cancer |
| title | H3K79me3T80ph is a Novel Histone Dual Modification and a Mitotic Indicator in Melanoma |
| title_full | H3K79me3T80ph is a Novel Histone Dual Modification and a Mitotic Indicator in Melanoma |
| title_fullStr | H3K79me3T80ph is a Novel Histone Dual Modification and a Mitotic Indicator in Melanoma |
| title_full_unstemmed | H3K79me3T80ph is a Novel Histone Dual Modification and a Mitotic Indicator in Melanoma |
| title_short | H3K79me3T80ph is a Novel Histone Dual Modification and a Mitotic Indicator in Melanoma |
| title_sort | h3k79me3t80ph is a novel histone dual modification and a mitotic indicator in melanoma |
| url | http://dx.doi.org/10.1155/2012/823534 |
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