Hyperinsulinemic Hypoglycemia and Growth Hormone Deficiency Secondary to 20p11 Deletion
Hypoglycemia is concerning for neurological complications in infants and children. Determining the cause of hypoglycemia is essential in providing appropriate treatment. Hyperinsulinism and growth hormone deficiency are known causes of hypoglycemia but are not commonly found together. We report a 4-...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2023/8658540 |
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| author | Erica Wee John Herriges Kavitha Dileepan Sarah L. Tsai Joseph T. Alaimo Emily Paprocki |
| author_facet | Erica Wee John Herriges Kavitha Dileepan Sarah L. Tsai Joseph T. Alaimo Emily Paprocki |
| author_sort | Erica Wee |
| collection | DOAJ |
| description | Hypoglycemia is concerning for neurological complications in infants and children. Determining the cause of hypoglycemia is essential in providing appropriate treatment. Hyperinsulinism and growth hormone deficiency are known causes of hypoglycemia but are not commonly found together. We report a 4-month-old boy who presented with severe hypoglycemia and was found to have both hyperinsulinism and growth hormone deficiency. Treatment with both recombinant human growth hormone and diazoxide led to blood glucose normalization. Subsequently, he was found to have a genetic diagnosis of 20p11.22p11.21 deletion. 20p11 deletions have been associated with hypopituitarism, most commonly seen in growth hormone deficiency causing hypoglycemia. This case is one of a few to report hyperinsulinism as a manifestation of this deletion. |
| format | Article |
| id | doaj-art-e3985ee070bc47959b105e52a37a01bd |
| institution | OA Journals |
| issn | 2090-651X |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-e3985ee070bc47959b105e52a37a01bd2025-08-20T02:21:24ZengWileyCase Reports in Endocrinology2090-651X2023-01-01202310.1155/2023/8658540Hyperinsulinemic Hypoglycemia and Growth Hormone Deficiency Secondary to 20p11 DeletionErica Wee0John Herriges1Kavitha Dileepan2Sarah L. Tsai3Joseph T. Alaimo4Emily Paprocki5Division of Pediatric Endocrinology and DiabetesUniversity of Missouri-Kansas City School of MedicineDivision of Pediatric Endocrinology and DiabetesDivision of Pediatric Endocrinology and DiabetesUniversity of Missouri-Kansas City School of MedicineDivision of Pediatric Endocrinology and DiabetesHypoglycemia is concerning for neurological complications in infants and children. Determining the cause of hypoglycemia is essential in providing appropriate treatment. Hyperinsulinism and growth hormone deficiency are known causes of hypoglycemia but are not commonly found together. We report a 4-month-old boy who presented with severe hypoglycemia and was found to have both hyperinsulinism and growth hormone deficiency. Treatment with both recombinant human growth hormone and diazoxide led to blood glucose normalization. Subsequently, he was found to have a genetic diagnosis of 20p11.22p11.21 deletion. 20p11 deletions have been associated with hypopituitarism, most commonly seen in growth hormone deficiency causing hypoglycemia. This case is one of a few to report hyperinsulinism as a manifestation of this deletion.http://dx.doi.org/10.1155/2023/8658540 |
| spellingShingle | Erica Wee John Herriges Kavitha Dileepan Sarah L. Tsai Joseph T. Alaimo Emily Paprocki Hyperinsulinemic Hypoglycemia and Growth Hormone Deficiency Secondary to 20p11 Deletion Case Reports in Endocrinology |
| title | Hyperinsulinemic Hypoglycemia and Growth Hormone Deficiency Secondary to 20p11 Deletion |
| title_full | Hyperinsulinemic Hypoglycemia and Growth Hormone Deficiency Secondary to 20p11 Deletion |
| title_fullStr | Hyperinsulinemic Hypoglycemia and Growth Hormone Deficiency Secondary to 20p11 Deletion |
| title_full_unstemmed | Hyperinsulinemic Hypoglycemia and Growth Hormone Deficiency Secondary to 20p11 Deletion |
| title_short | Hyperinsulinemic Hypoglycemia and Growth Hormone Deficiency Secondary to 20p11 Deletion |
| title_sort | hyperinsulinemic hypoglycemia and growth hormone deficiency secondary to 20p11 deletion |
| url | http://dx.doi.org/10.1155/2023/8658540 |
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