Blocking TSP1 Ameliorates Diabetes Mellitus-Induced Erectile Dysfunction by Inhibiting the TGF-β/SMAD Pathway

Blocking TSP1 Ameliorates Diabetes Mellitus-Induced Erectile Dysfunction by Inhibiting the TGF-β/SMAD Pathway

Purpose: To examine the role and mechanism of thrombospondin-1 (TSP1) in the development of fibrosis in diabetes mellitus- induced erectile dysfunction (DMED). Materials and Methods: DMED was induced by intraperitoneal streptozotocin injection. All rats were categorized into three groups: control...

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Main Authors: Mancheng Xia, Yiming Yuan, Dong Fang, Xiaohui Tan, Fangzhou Zhao, Xinfei Li, Pengchao Gao, Zhuo Zhou, Tiegui Nan, Zhongcheng Xin, Xuesong Li, Ruili Guan
Format: Article
Language:English
Published: Korean Society for Sexual Medicine and Andrology 2025-07-01
Series:The World Journal of Men's Health
Subjects:
diabetes mellitus
erectile dysfunction
fibrosis
transforming growth factor beta1
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