Integrated omics profiling reveals systemic dysregulation and potential biomarkers in the blood of patients with neuromyelitis optica spectrum disorders

Integrated omics profiling reveals systemic dysregulation and potential biomarkers in the blood of patients with neuromyelitis optica spectrum disorders

Abstract Background Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune conditions that affect the central nervous system. The contribution of peripheral abnormalities to the disease's pathogenesis is not well understood. Methods To investigate this, we employed a multi-omics approac...

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Bibliographic Details
Main Authors: Zuoquan Xie, Qinming Zhou, Jin Hu, Lu He, Huangyu Meng, Xiaoni Liu, Guangqiang Sun, Zhiyu Luo, Yuan Feng, Liang Li, Xingkun Chu, Chen Du, Dabing Yang, Xinying Yang, Jing Zhang, Changrong Ge, Xiang Zhang, Sheng Chen, Meiyu Geng
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Translational Medicine
Subjects:
Neuromyelitis optica spectrum disorders
Blood immune cells phenotyping
Plasma cytokine array
Plasma metabolomics
Biomarker
Online Access:https://doi.org/10.1186/s12967-024-05801-8
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