Pharmacological effects, molecular mechanisms, and pharmacokinetics of benzoylaconine: a systematic review
Benzoylaconine (BAC), a key active metabolite in traditional Chinese medicine, is derived from the subsoil roots of Fuzi (Aconitum carmichaelii Debx [Ranunculaceae, Aconitum carmichaelii Debx roots]). BAC has garnered considerable research attention because of its therapeutic effects against cardiov...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1571153/full |
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| author | Huamei Zhuang Huamei Zhuang Hong Yao Hong Yao |
| author_facet | Huamei Zhuang Huamei Zhuang Hong Yao Hong Yao |
| author_sort | Huamei Zhuang |
| collection | DOAJ |
| description | Benzoylaconine (BAC), a key active metabolite in traditional Chinese medicine, is derived from the subsoil roots of Fuzi (Aconitum carmichaelii Debx [Ranunculaceae, Aconitum carmichaelii Debx roots]). BAC has garnered considerable research attention because of its therapeutic effects against cardiovascular disease, inflammation, and arthritis, and this has led to continual updates in the literature. This systematic review summarizes evidence on the pharmacological effects, molecular mechanisms, and pharmacokinetics of BAC. PubMed and Web of Science were searched for relevant articles published between January 2000 and November 2024. Genes, proteins, and pathways related to the activity and therapeutic effects of BAC were identified. BAC usually targets proteins such as ACE2, IL-6, MAPK, PI3K, Akt, STAT3, TNF-α, and VEGF. The identified genes and proteins were subjected to protein–protein interaction analysis, molecular docking between BAC and protein hubs, and bioinformatic analyses (gene ontology, Kyoto Encyclopedia of Genes and Genomes, and disease ontology analyses). Protein–protein interaction analysis and molecular docking indicated IL-6, Akt1, and STAT3 as key targets of BAC. These findings offer theoretical insights into the potential therapeutic mechanisms of BAC and may inform its future development as a pharmacological agent. |
| format | Article |
| id | doaj-art-e394f9c5d7d44ad89ec6ca3a993337d5 |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-e394f9c5d7d44ad89ec6ca3a993337d52025-08-20T03:04:55ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-08-011610.3389/fphar.2025.15711531571153Pharmacological effects, molecular mechanisms, and pharmacokinetics of benzoylaconine: a systematic reviewHuamei Zhuang0Huamei Zhuang1Hong Yao2Hong Yao3School of Pharmacy and Medical technology, Putian University, Putian, ChinaKey Laboratory of Pharmaceutical Analysis and Laboratory Medicine, Putian University, Putian, ChinaDepartment of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou, ChinaFujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, Fujian Medical University, Fuzhou, ChinaBenzoylaconine (BAC), a key active metabolite in traditional Chinese medicine, is derived from the subsoil roots of Fuzi (Aconitum carmichaelii Debx [Ranunculaceae, Aconitum carmichaelii Debx roots]). BAC has garnered considerable research attention because of its therapeutic effects against cardiovascular disease, inflammation, and arthritis, and this has led to continual updates in the literature. This systematic review summarizes evidence on the pharmacological effects, molecular mechanisms, and pharmacokinetics of BAC. PubMed and Web of Science were searched for relevant articles published between January 2000 and November 2024. Genes, proteins, and pathways related to the activity and therapeutic effects of BAC were identified. BAC usually targets proteins such as ACE2, IL-6, MAPK, PI3K, Akt, STAT3, TNF-α, and VEGF. The identified genes and proteins were subjected to protein–protein interaction analysis, molecular docking between BAC and protein hubs, and bioinformatic analyses (gene ontology, Kyoto Encyclopedia of Genes and Genomes, and disease ontology analyses). Protein–protein interaction analysis and molecular docking indicated IL-6, Akt1, and STAT3 as key targets of BAC. These findings offer theoretical insights into the potential therapeutic mechanisms of BAC and may inform its future development as a pharmacological agent.https://www.frontiersin.org/articles/10.3389/fphar.2025.1571153/fullbenzoylaconinetoxicitypharmacokineticspharmacological activitymolecular mechanisms |
| spellingShingle | Huamei Zhuang Huamei Zhuang Hong Yao Hong Yao Pharmacological effects, molecular mechanisms, and pharmacokinetics of benzoylaconine: a systematic review Frontiers in Pharmacology benzoylaconine toxicity pharmacokinetics pharmacological activity molecular mechanisms |
| title | Pharmacological effects, molecular mechanisms, and pharmacokinetics of benzoylaconine: a systematic review |
| title_full | Pharmacological effects, molecular mechanisms, and pharmacokinetics of benzoylaconine: a systematic review |
| title_fullStr | Pharmacological effects, molecular mechanisms, and pharmacokinetics of benzoylaconine: a systematic review |
| title_full_unstemmed | Pharmacological effects, molecular mechanisms, and pharmacokinetics of benzoylaconine: a systematic review |
| title_short | Pharmacological effects, molecular mechanisms, and pharmacokinetics of benzoylaconine: a systematic review |
| title_sort | pharmacological effects molecular mechanisms and pharmacokinetics of benzoylaconine a systematic review |
| topic | benzoylaconine toxicity pharmacokinetics pharmacological activity molecular mechanisms |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1571153/full |
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