D-pinitol modulates the anti-emetic effects of aprepitant, domperidone, and ondansetron in chicks
Naturally occurring substance, D-pinitol (DPL) belongs to the significant inositol family has numerous pharmacological activity. In this study we evaluated the anti-emetic effect as well as modulation activities of DPL on the recent market drugs aprepitant (APR), domperidone (DOM), hyoscine butyl br...
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Elsevier
2025-12-01
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| Series: | Pharmaceutical Science Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S277321692500011X |
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| author | Md. Elit Rahman Md. Anisur Rahman Salehin Sheikh Md. Jannatul Islam Polash Sozoni Khatun Mst. Sonia Akter Bristi Md. Showkoth Akbor Mst. Farjanamul Haque Mehedi Hasan Bappi Tohidul Islam Tanim Siddique Akber Ansari Irfan Aamer Ansari Elaine Cristina Pereira Lucetti Carolina Bandeira Domiciano Henrique D.M. Coutinho Muhammad Torequl Islam |
| author_facet | Md. Elit Rahman Md. Anisur Rahman Salehin Sheikh Md. Jannatul Islam Polash Sozoni Khatun Mst. Sonia Akter Bristi Md. Showkoth Akbor Mst. Farjanamul Haque Mehedi Hasan Bappi Tohidul Islam Tanim Siddique Akber Ansari Irfan Aamer Ansari Elaine Cristina Pereira Lucetti Carolina Bandeira Domiciano Henrique D.M. Coutinho Muhammad Torequl Islam |
| author_sort | Md. Elit Rahman |
| collection | DOAJ |
| description | Naturally occurring substance, D-pinitol (DPL) belongs to the significant inositol family has numerous pharmacological activity. In this study we evaluated the anti-emetic effect as well as modulation activities of DPL on the recent market drugs aprepitant (APR), domperidone (DOM), hyoscine butyl bromide (HYS), and ondansetron (ODN) on emesis in the chick model. To highlight the possible anti-emetic activity in copper sulfate induced emesis chick models, we use several reference drugs, such as APR (26 mg/kg), DOM (7 mg/kg), OND (5 mg/kg), and HYS (21 mg/kg), as positive controls, while the vehicles serve as negative controls. All reference drugs are given alone or in combined groups to evaluate their anti-emetic and modulation effects. The results suggest DPL (25 or 50 mg/kg) increases the mean number of latency in the chicks compared to vehicles, and the combination groups, DPL (25 mg/kg) showed better anti-emetic effects with DOM and ODN while DPL (50 mg/kg) reduces the number of retches compared to vehicles and combined drug therapy with reference drugs. Additionally, A variety of computational algorithms were used to visualise ligand–receptor interactions and quantify the binding affinities of DPL and other ligands towards the dopamine receptors (D2 and D3), muscarinic acetylcholine receptors (M1–M5), and serotonin receptor (5HT3). The molecular docking study indicated that DPL exhibits the highest binding affinity towards subtypes M2 (having a docking score of −5.7 kcal/mol) and D3 (having a docking score of −5.7 kcal/mol) in comparison to certain standards for these receptors, which have docking scores of DOM (−9.7 kcal/mol) and HYS (−7.1 kcal/mol) for M2 and D3, respectively. Our findings suggest that DPL has anti-emetic properties in chicks, possibly through interactions with the M2 and D3 receptor pathways. |
| format | Article |
| id | doaj-art-e3946200635343479c0ec88d3eb91c3d |
| institution | DOAJ |
| issn | 2773-2169 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
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| series | Pharmaceutical Science Advances |
| spelling | doaj-art-e3946200635343479c0ec88d3eb91c3d2025-08-20T03:08:18ZengElsevierPharmaceutical Science Advances2773-21692025-12-01310007310.1016/j.pscia.2025.100073D-pinitol modulates the anti-emetic effects of aprepitant, domperidone, and ondansetron in chicksMd. Elit Rahman0Md. Anisur Rahman1Salehin Sheikh2Md. Jannatul Islam Polash3Sozoni Khatun4Mst. Sonia Akter Bristi5Md. Showkoth Akbor6Mst. Farjanamul Haque7Mehedi Hasan Bappi8Tohidul Islam Tanim9Siddique Akber Ansari10Irfan Aamer Ansari11Elaine Cristina Pereira Lucetti12Carolina Bandeira Domiciano13Henrique D.M. Coutinho14Muhammad Torequl Islam15Department of Pharmacy, Gopalganj Science and Technology University, Gopalganj-8100, BangladeshDepartment of Pharmacy, Islamic University, Kushtia, 7003, Bangladesh; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center, Gopalganj 8100, BangladeshDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj-8100, Bangladesh; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center, Gopalganj 8100, BangladeshDepartment of Pharmacy, Islamic University, Kushtia, 7003, BangladeshDepartment of Pharmacy, Islamic University, Kushtia, 7003, BangladeshDepartment of Chemistry, Kabi Nazrul Govt. College, University of Dhaka, BangladeshDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj-8100, BangladeshDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj-8100, BangladeshDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj-8100, Bangladesh; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center, Gopalganj 8100, BangladeshDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj-8100, BangladeshDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Drug Science and Technology, University of Turin, Turin, 10124, ItalyCECAPE College. Av. Padre Cícero, 3917 - São José, Juazeiro do Norte, CE, 63024-015, BrazilCenter of Medical Sciences, Federal University of Paraíba – UFPB, João Pessoa, 58297-000, BrazilDepartment of Biological Chemistry, Regional University of Cariri, Crato, CE, 63105-000, Brazil; Corresponding author.Department of Pharmacy, Gopalganj Science and Technology University, Gopalganj-8100, Bangladesh; Pharmacy Discipline, Khulna University, Khulna, 9208, Bangladesh; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center, Gopalganj 8100, Bangladesh; Corresponding author. Department of Pharmacy, Gopalganj Science and Technology University, Gopalganj-8100, Bangladesh.Naturally occurring substance, D-pinitol (DPL) belongs to the significant inositol family has numerous pharmacological activity. In this study we evaluated the anti-emetic effect as well as modulation activities of DPL on the recent market drugs aprepitant (APR), domperidone (DOM), hyoscine butyl bromide (HYS), and ondansetron (ODN) on emesis in the chick model. To highlight the possible anti-emetic activity in copper sulfate induced emesis chick models, we use several reference drugs, such as APR (26 mg/kg), DOM (7 mg/kg), OND (5 mg/kg), and HYS (21 mg/kg), as positive controls, while the vehicles serve as negative controls. All reference drugs are given alone or in combined groups to evaluate their anti-emetic and modulation effects. The results suggest DPL (25 or 50 mg/kg) increases the mean number of latency in the chicks compared to vehicles, and the combination groups, DPL (25 mg/kg) showed better anti-emetic effects with DOM and ODN while DPL (50 mg/kg) reduces the number of retches compared to vehicles and combined drug therapy with reference drugs. Additionally, A variety of computational algorithms were used to visualise ligand–receptor interactions and quantify the binding affinities of DPL and other ligands towards the dopamine receptors (D2 and D3), muscarinic acetylcholine receptors (M1–M5), and serotonin receptor (5HT3). The molecular docking study indicated that DPL exhibits the highest binding affinity towards subtypes M2 (having a docking score of −5.7 kcal/mol) and D3 (having a docking score of −5.7 kcal/mol) in comparison to certain standards for these receptors, which have docking scores of DOM (−9.7 kcal/mol) and HYS (−7.1 kcal/mol) for M2 and D3, respectively. Our findings suggest that DPL has anti-emetic properties in chicks, possibly through interactions with the M2 and D3 receptor pathways.http://www.sciencedirect.com/science/article/pii/S277321692500011XAnti-emeticEmesisD-pinitolMolecular dockingPharmacokineticsToxicity |
| spellingShingle | Md. Elit Rahman Md. Anisur Rahman Salehin Sheikh Md. Jannatul Islam Polash Sozoni Khatun Mst. Sonia Akter Bristi Md. Showkoth Akbor Mst. Farjanamul Haque Mehedi Hasan Bappi Tohidul Islam Tanim Siddique Akber Ansari Irfan Aamer Ansari Elaine Cristina Pereira Lucetti Carolina Bandeira Domiciano Henrique D.M. Coutinho Muhammad Torequl Islam D-pinitol modulates the anti-emetic effects of aprepitant, domperidone, and ondansetron in chicks Pharmaceutical Science Advances Anti-emetic Emesis D-pinitol Molecular docking Pharmacokinetics Toxicity |
| title | D-pinitol modulates the anti-emetic effects of aprepitant, domperidone, and ondansetron in chicks |
| title_full | D-pinitol modulates the anti-emetic effects of aprepitant, domperidone, and ondansetron in chicks |
| title_fullStr | D-pinitol modulates the anti-emetic effects of aprepitant, domperidone, and ondansetron in chicks |
| title_full_unstemmed | D-pinitol modulates the anti-emetic effects of aprepitant, domperidone, and ondansetron in chicks |
| title_short | D-pinitol modulates the anti-emetic effects of aprepitant, domperidone, and ondansetron in chicks |
| title_sort | d pinitol modulates the anti emetic effects of aprepitant domperidone and ondansetron in chicks |
| topic | Anti-emetic Emesis D-pinitol Molecular docking Pharmacokinetics Toxicity |
| url | http://www.sciencedirect.com/science/article/pii/S277321692500011X |
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