Therapeutic thrombocytapheresis short-term efficacy and hematologic impact: comparing MNC procedure of COBE spectra and PLT-5d C5L procedure of COM.TEC
Abstract Due to the disruption in the supply of consumables for platelet separation on the COBE Spectra blood component separator in China, we have performed therapeutic thrombocytapheresis using its mononuclear cell collection procedure (MNC procedure) and compared it with the therapy by COM.TEC pl...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-05282-9 |
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| author | Yong Wu Yuanjun Wu Huisen Li Siyuan Liang Dongsheng Wu Baochan Chen Yan Liu Yueqin Wu Qian Wang |
| author_facet | Yong Wu Yuanjun Wu Huisen Li Siyuan Liang Dongsheng Wu Baochan Chen Yan Liu Yueqin Wu Qian Wang |
| author_sort | Yong Wu |
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| description | Abstract Due to the disruption in the supply of consumables for platelet separation on the COBE Spectra blood component separator in China, we have performed therapeutic thrombocytapheresis using its mononuclear cell collection procedure (MNC procedure) and compared it with the therapy by COM.TEC platelet donation procedure to compare the influence on patient blood cell indicators. Therapeutic thrombocytapheresis was conducted 69 and 35 times on 38 and 15 clonal thrombocytosis patients using the MNC procedure with the COBE Spectra (MNC group) and the PLT-5d C5L procedure of the COM.TEC platelet donation package (PLT-5d C5L group), respectively. In the MNC and PLT-5d C5L groups, the therapy durations and the processed blood volumes were similar: platelet removal rates, 60.56% (53.59–75.81%) and (84.95 ± 39.46)% (z = 3.017, p < 0.01); white blood cell (WBC) loss values, 2.85 (2.02–3.83) × 109/L and 0.69 (0.23–1.47) × 109/L (z = 8.307, p < 0.001); and haemoglobin (Hb) loss values, 0.75 (0.50–1.09) g/L and 0.03 (0.02–0.20) g/L (z = 8.311, p < 0.001) in the MNC and PLT-5d C5L groups, respectively. However, the WBC count decreased by 1.28 (− 0.84 to 2.49) × 109/L and (2.97 ± 3.49) × 109/L (z = 2.825, p < 0.01), and the Hb level decreased by (3.38 ± 9.36) g/L and (9.06 ± 7.05) g/L (t = − 3.158, p < 0.01) in the MNC and PLT-5d C5L groups, respectively. The results show that, compared with the COBE Spectra MNC procedure, although the COM.TEC platelet donation package PLT-5d C5L procedure demonstrated higher therapeutic thrombocytapheresis efficiency, it also resulted in a greater decrease in WBCs and Hb. |
| format | Article |
| id | doaj-art-e3938578929c499a8fc511ad531af0c3 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
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| spelling | doaj-art-e3938578929c499a8fc511ad531af0c32025-08-20T03:37:20ZengNature PortfolioScientific Reports2045-23222025-07-011511610.1038/s41598-025-05282-9Therapeutic thrombocytapheresis short-term efficacy and hematologic impact: comparing MNC procedure of COBE spectra and PLT-5d C5L procedure of COM.TECYong Wu0Yuanjun Wu1Huisen Li2Siyuan Liang3Dongsheng Wu4Baochan Chen5Yan Liu6Yueqin Wu7Qian Wang8Department of Transfusion Medicine, Dongguan Tungwah HospitalDepartment of Transfusion Medicine, Dongguan Maternal and Child Health Care HospitalDepartment of Transfusion Medicine, Dongguan Tungwah HospitalDepartment of Transfusion Medicine, Dongguan Tungwah HospitalDepartment of Hematology, Dongguan Tungwah HospitalDepartment of Transfusion Medicine, Dongguan Tungwah HospitalDepartment of Transfusion Medicine, Dongguan Tungwah HospitalDepartment of Transfusion Medicine, Dongguan Songshan Lake Tungwah HospitalDepartment of Hematology, Dongguan Tungwah HospitalAbstract Due to the disruption in the supply of consumables for platelet separation on the COBE Spectra blood component separator in China, we have performed therapeutic thrombocytapheresis using its mononuclear cell collection procedure (MNC procedure) and compared it with the therapy by COM.TEC platelet donation procedure to compare the influence on patient blood cell indicators. Therapeutic thrombocytapheresis was conducted 69 and 35 times on 38 and 15 clonal thrombocytosis patients using the MNC procedure with the COBE Spectra (MNC group) and the PLT-5d C5L procedure of the COM.TEC platelet donation package (PLT-5d C5L group), respectively. In the MNC and PLT-5d C5L groups, the therapy durations and the processed blood volumes were similar: platelet removal rates, 60.56% (53.59–75.81%) and (84.95 ± 39.46)% (z = 3.017, p < 0.01); white blood cell (WBC) loss values, 2.85 (2.02–3.83) × 109/L and 0.69 (0.23–1.47) × 109/L (z = 8.307, p < 0.001); and haemoglobin (Hb) loss values, 0.75 (0.50–1.09) g/L and 0.03 (0.02–0.20) g/L (z = 8.311, p < 0.001) in the MNC and PLT-5d C5L groups, respectively. However, the WBC count decreased by 1.28 (− 0.84 to 2.49) × 109/L and (2.97 ± 3.49) × 109/L (z = 2.825, p < 0.01), and the Hb level decreased by (3.38 ± 9.36) g/L and (9.06 ± 7.05) g/L (t = − 3.158, p < 0.01) in the MNC and PLT-5d C5L groups, respectively. The results show that, compared with the COBE Spectra MNC procedure, although the COM.TEC platelet donation package PLT-5d C5L procedure demonstrated higher therapeutic thrombocytapheresis efficiency, it also resulted in a greater decrease in WBCs and Hb.https://doi.org/10.1038/s41598-025-05282-9PlateletsThrombocytosisTherapeutic thrombocytapheresisWhite blood cellsHemoglobin |
| spellingShingle | Yong Wu Yuanjun Wu Huisen Li Siyuan Liang Dongsheng Wu Baochan Chen Yan Liu Yueqin Wu Qian Wang Therapeutic thrombocytapheresis short-term efficacy and hematologic impact: comparing MNC procedure of COBE spectra and PLT-5d C5L procedure of COM.TEC Scientific Reports Platelets Thrombocytosis Therapeutic thrombocytapheresis White blood cells Hemoglobin |
| title | Therapeutic thrombocytapheresis short-term efficacy and hematologic impact: comparing MNC procedure of COBE spectra and PLT-5d C5L procedure of COM.TEC |
| title_full | Therapeutic thrombocytapheresis short-term efficacy and hematologic impact: comparing MNC procedure of COBE spectra and PLT-5d C5L procedure of COM.TEC |
| title_fullStr | Therapeutic thrombocytapheresis short-term efficacy and hematologic impact: comparing MNC procedure of COBE spectra and PLT-5d C5L procedure of COM.TEC |
| title_full_unstemmed | Therapeutic thrombocytapheresis short-term efficacy and hematologic impact: comparing MNC procedure of COBE spectra and PLT-5d C5L procedure of COM.TEC |
| title_short | Therapeutic thrombocytapheresis short-term efficacy and hematologic impact: comparing MNC procedure of COBE spectra and PLT-5d C5L procedure of COM.TEC |
| title_sort | therapeutic thrombocytapheresis short term efficacy and hematologic impact comparing mnc procedure of cobe spectra and plt 5d c5l procedure of com tec |
| topic | Platelets Thrombocytosis Therapeutic thrombocytapheresis White blood cells Hemoglobin |
| url | https://doi.org/10.1038/s41598-025-05282-9 |
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