Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
Diabetic kidney disease (DKD) represents serious diabetes-associated complications, and podocyte loss is an important histologic sign of DKD. The cellular and molecular profiles of podocytes in DKD have yet to be fully elucidated.
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-04-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2025-1146 |
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| author | Zhang Fengxia Tang Xianhu Zeng Zhimei Cao Chunyu Yun Caocui Shen Yue Nie Chaohong Xiong Ying Chulian Mao Wu Yueheng Xu Ruiquan |
| author_facet | Zhang Fengxia Tang Xianhu Zeng Zhimei Cao Chunyu Yun Caocui Shen Yue Nie Chaohong Xiong Ying Chulian Mao Wu Yueheng Xu Ruiquan |
| author_sort | Zhang Fengxia |
| collection | DOAJ |
| description | Diabetic kidney disease (DKD) represents serious diabetes-associated complications, and podocyte loss is an important histologic sign of DKD. The cellular and molecular profiles of podocytes in DKD have yet to be fully elucidated. |
| format | Article |
| id | doaj-art-e392981d086c4ba1a974ea7e3cb141d9 |
| institution | DOAJ |
| issn | 2391-5463 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj-art-e392981d086c4ba1a974ea7e3cb141d92025-08-20T03:17:56ZengDe GruyterOpen Medicine2391-54632025-04-012016590134410.1515/med-2025-1146Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathyZhang Fengxia0Tang Xianhu1Zeng Zhimei2Cao Chunyu3Yun Caocui4Shen Yue5Nie Chaohong6Xiong Ying7Chulian Mao8Wu Yueheng9Xu Ruiquan10Department of Nephrology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Nephrology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Stomatology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Nephrology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Nephrology, Shaoxing People’s Hospital, Shaoxing, Zhejiang, ChinaDepartment of Nephrology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Nephrology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Nephrology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Nephrology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaGuangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, ChinaDepartment of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, Jiangxi, ChinaDiabetic kidney disease (DKD) represents serious diabetes-associated complications, and podocyte loss is an important histologic sign of DKD. The cellular and molecular profiles of podocytes in DKD have yet to be fully elucidated.https://doi.org/10.1515/med-2025-1146diabetic kidney disease, dkdsingle-nucleus rna sequencing, snrna-seqpodocytearhgap28 |
| spellingShingle | Zhang Fengxia Tang Xianhu Zeng Zhimei Cao Chunyu Yun Caocui Shen Yue Nie Chaohong Xiong Ying Chulian Mao Wu Yueheng Xu Ruiquan Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy Open Medicine diabetic kidney disease, dkd single-nucleus rna sequencing, snrna-seq podocyte arhgap28 |
| title | Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy |
| title_full | Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy |
| title_fullStr | Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy |
| title_full_unstemmed | Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy |
| title_short | Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy |
| title_sort | single nucleus rna sequencing reveals arhgap28 expression of podocytes as a biomarker in human diabetic nephropathy |
| topic | diabetic kidney disease, dkd single-nucleus rna sequencing, snrna-seq podocyte arhgap28 |
| url | https://doi.org/10.1515/med-2025-1146 |
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