p53-dependent chromatin relaxation is required for DNA double-strand break repair

p53-dependent chromatin relaxation is required for DNA double-strand break repair

The tumor suppressor p53, an indispensable nuclear transcription factor, plays a central role in orchestrating cellular responses when DNA damage occurs. In this study, we demonstrate that in the initial phases of DNA double-strand break (DSB) repair, p53 is rapidly recruited to sites of damage and...

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Bibliographic Details
Main Authors: Chen Hongyu, Shan Jin, Qi Wenjing, Chen Lili, Zeng Xianlu
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2025-02-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
DNA damage repair
DNA double-strand breaks (DSBs)
p53
chromatin relaxation
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2025008
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