Potential mechanisms and clinical applications of static magnetic field therapy in glioma
Static magnetic field (SMF) therapy, a non-ionizing and non-invasive treatment modality, has garnered increasing attention in glioma research. Gliomas, particularly glioblastoma (GBM), represent one of the most aggressive malignancies of the central nervous system, with limited therapeutic options a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1594874/full |
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| author | Ziyu Sun Kairui Zhu Wenxuan Zhao Xi-feng Fei Lei Shi Yong Zhang |
| author_facet | Ziyu Sun Kairui Zhu Wenxuan Zhao Xi-feng Fei Lei Shi Yong Zhang |
| author_sort | Ziyu Sun |
| collection | DOAJ |
| description | Static magnetic field (SMF) therapy, a non-ionizing and non-invasive treatment modality, has garnered increasing attention in glioma research. Gliomas, particularly glioblastoma (GBM), represent one of the most aggressive malignancies of the central nervous system, with limited therapeutic options and significant treatment-related toxicity. Emerging evidence suggests that SMF therapy exerts antitumor effects by inducing apoptosis, inhibiting cell proliferation, and modulating the tumor microenvironment, while minimizing damage to surrounding healthy tissues. Despite promising preclinical findings, research on SMF therapy remains in its early stages, and its precise mechanisms, clinical efficacy, and safety require further elucidation. This review summarizes current advancements in SMF therapy for gliomas, explores its potential as a standalone or adjunctive treatment, and discusses future research directions to optimize its therapeutic application. |
| format | Article |
| id | doaj-art-e38ba9155a484a0a930277d5c4494f83 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-e38ba9155a484a0a930277d5c4494f832025-08-20T03:26:33ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-06-011610.3389/fneur.2025.15948741594874Potential mechanisms and clinical applications of static magnetic field therapy in gliomaZiyu Sun0Kairui Zhu1Wenxuan Zhao2Xi-feng Fei3Lei Shi4Yong Zhang5Department of Neurosurgery, The First People’s Hospital of Kunshan, Gusu School, Nanjing Medical University, Suzhou, ChinaDepartment of Neurosurgery and Nursing, Affiliated Kunshan Hospital to Jiangsu University, Suzhou, ChinaDepartment of Neurosurgery, The First People’s Hospital of Kunshan, Gusu School, Nanjing Medical University, Suzhou, ChinaDepartment of Neurosurgery, Suzhou Kowloon Hospital, Shanghai Jiaotong University School of Medicine, Suzhou, ChinaDepartment of Neurosurgery, The First People’s Hospital of Kunshan, Gusu School, Nanjing Medical University, Suzhou, ChinaDepartment of Neurosurgery and Nursing, Affiliated Kunshan Hospital to Jiangsu University, Suzhou, ChinaStatic magnetic field (SMF) therapy, a non-ionizing and non-invasive treatment modality, has garnered increasing attention in glioma research. Gliomas, particularly glioblastoma (GBM), represent one of the most aggressive malignancies of the central nervous system, with limited therapeutic options and significant treatment-related toxicity. Emerging evidence suggests that SMF therapy exerts antitumor effects by inducing apoptosis, inhibiting cell proliferation, and modulating the tumor microenvironment, while minimizing damage to surrounding healthy tissues. Despite promising preclinical findings, research on SMF therapy remains in its early stages, and its precise mechanisms, clinical efficacy, and safety require further elucidation. This review summarizes current advancements in SMF therapy for gliomas, explores its potential as a standalone or adjunctive treatment, and discusses future research directions to optimize its therapeutic application.https://www.frontiersin.org/articles/10.3389/fneur.2025.1594874/fullgliomastatic magnetic fieldnon-invasive treatmentapoptosistumor microenvironment |
| spellingShingle | Ziyu Sun Kairui Zhu Wenxuan Zhao Xi-feng Fei Lei Shi Yong Zhang Potential mechanisms and clinical applications of static magnetic field therapy in glioma Frontiers in Neurology glioma static magnetic field non-invasive treatment apoptosis tumor microenvironment |
| title | Potential mechanisms and clinical applications of static magnetic field therapy in glioma |
| title_full | Potential mechanisms and clinical applications of static magnetic field therapy in glioma |
| title_fullStr | Potential mechanisms and clinical applications of static magnetic field therapy in glioma |
| title_full_unstemmed | Potential mechanisms and clinical applications of static magnetic field therapy in glioma |
| title_short | Potential mechanisms and clinical applications of static magnetic field therapy in glioma |
| title_sort | potential mechanisms and clinical applications of static magnetic field therapy in glioma |
| topic | glioma static magnetic field non-invasive treatment apoptosis tumor microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1594874/full |
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