Growth Hormone and Reproduction: A Review of Endocrine and Autocrine/Paracrine Interactions
The somatotropic axis, consisting of growth hormone (GH), hepatic insulin-like growth factor I (IGF-I), and assorted releasing factors, regulates growth and body composition. Axiomatically, since optimal body composition enhances reproductive function, general somatic actions of GH modulate reproduc...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/234014 |
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| _version_ | 1832563948739624960 |
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| author | Kerry L. Hull Steve Harvey |
| author_facet | Kerry L. Hull Steve Harvey |
| author_sort | Kerry L. Hull |
| collection | DOAJ |
| description | The somatotropic axis, consisting of growth hormone (GH), hepatic insulin-like growth factor I (IGF-I), and assorted releasing factors, regulates growth and body composition. Axiomatically, since optimal body composition enhances reproductive function, general somatic actions of GH modulate reproductive function. A growing body of evidence supports the hypothesis that GH also modulates reproduction directly, exerting both gonadotropin-dependent and gonadotropin-independent actions in both males and females. Moreover, recent studies indicate GH produced within reproductive tissues differs from pituitary GH in terms of secretion and action. Accordingly, GH is increasingly used as a fertility adjunct in males and females, both humans and nonhumans. This review reconsiders reproductive actions of GH in vertebrates in respect to these new conceptual developments. |
| format | Article |
| id | doaj-art-e38479ef989b4dc4b5a11085972f8c25 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-e38479ef989b4dc4b5a11085972f8c252025-02-03T01:12:12ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/234014234014Growth Hormone and Reproduction: A Review of Endocrine and Autocrine/Paracrine InteractionsKerry L. Hull0Steve Harvey1Department of Biology, Bishop’s University, Sherbrooke, QC, J1M 1Z7, CanadaDepartment of Physiology, University of Alberta, Edmonton, AB, T6G 2R3, CanadaThe somatotropic axis, consisting of growth hormone (GH), hepatic insulin-like growth factor I (IGF-I), and assorted releasing factors, regulates growth and body composition. Axiomatically, since optimal body composition enhances reproductive function, general somatic actions of GH modulate reproductive function. A growing body of evidence supports the hypothesis that GH also modulates reproduction directly, exerting both gonadotropin-dependent and gonadotropin-independent actions in both males and females. Moreover, recent studies indicate GH produced within reproductive tissues differs from pituitary GH in terms of secretion and action. Accordingly, GH is increasingly used as a fertility adjunct in males and females, both humans and nonhumans. This review reconsiders reproductive actions of GH in vertebrates in respect to these new conceptual developments.http://dx.doi.org/10.1155/2014/234014 |
| spellingShingle | Kerry L. Hull Steve Harvey Growth Hormone and Reproduction: A Review of Endocrine and Autocrine/Paracrine Interactions International Journal of Endocrinology |
| title | Growth Hormone and Reproduction: A Review of Endocrine and Autocrine/Paracrine Interactions |
| title_full | Growth Hormone and Reproduction: A Review of Endocrine and Autocrine/Paracrine Interactions |
| title_fullStr | Growth Hormone and Reproduction: A Review of Endocrine and Autocrine/Paracrine Interactions |
| title_full_unstemmed | Growth Hormone and Reproduction: A Review of Endocrine and Autocrine/Paracrine Interactions |
| title_short | Growth Hormone and Reproduction: A Review of Endocrine and Autocrine/Paracrine Interactions |
| title_sort | growth hormone and reproduction a review of endocrine and autocrine paracrine interactions |
| url | http://dx.doi.org/10.1155/2014/234014 |
| work_keys_str_mv | AT kerrylhull growthhormoneandreproductionareviewofendocrineandautocrineparacrineinteractions AT steveharvey growthhormoneandreproductionareviewofendocrineandautocrineparacrineinteractions |