Recent approaches in the drug research and development of novel antimalarial drugs with new targets
Malaria is a serious worldwide medical issue that results in substantial annual death and morbidity. The availability of treatment alternatives is limited, and the rise of resistant parasite types has posed a significant challenge to malaria treatment. To prevent a public health disaster, novel anti...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2023-03-01
|
| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/acph-2023-0001 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832572845023035392 |
|---|---|
| author | Chinnappanna Naveen Kumar Reddy Yennam Gopi Chaitanya Chaitanya Budagam Haima Naga Venkata Pottathil Shinu Borah Pobitra Venugopala Katharigatta N. Deb Pran Kishore Mailavaram Raghu Prasad |
| author_facet | Chinnappanna Naveen Kumar Reddy Yennam Gopi Chaitanya Chaitanya Budagam Haima Naga Venkata Pottathil Shinu Borah Pobitra Venugopala Katharigatta N. Deb Pran Kishore Mailavaram Raghu Prasad |
| author_sort | Chinnappanna Naveen Kumar Reddy |
| collection | DOAJ |
| description | Malaria is a serious worldwide medical issue that results in substantial annual death and morbidity. The availability of treatment alternatives is limited, and the rise of resistant parasite types has posed a significant challenge to malaria treatment. To prevent a public health disaster, novel antimalarial agents with single-dosage therapies, extensive curative capability, and new mechanisms are urgently needed. There are several approaches to developing antimalarial drugs, ranging from alterations of current drugs to the creation of new compounds with specific targeting abilities. The availability of multiple genomic techniques, as well as recent advancements in parasite biology, provides a varied collection of possible targets for the development of novel treatments. A number of promising pharmacological interference targets have been uncovered in modern times. As a result, our review concentrates on the most current scientific and technical progress in the innovation of new antimalarial medications. The protein kinases, choline transport inhibitors, dihydroorotate dehydrogenase inhibitors, isoprenoid biosynthesis inhibitors, and enzymes involved in the metabolism of lipids and replication of deoxyribonucleic acid, are among the most fascinating antimalarial target proteins presently being investigated. The new cellular targets and drugs which can inhibit malaria and their development techniques are summarised in this study. |
| format | Article |
| id | doaj-art-e3844dd855d9495690923ed3afb65200 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-e3844dd855d9495690923ed3afb652002025-02-02T07:31:15ZengSciendoActa Pharmaceutica1846-95582023-03-0173112710.2478/acph-2023-0001Recent approaches in the drug research and development of novel antimalarial drugs with new targetsChinnappanna Naveen Kumar Reddy0Yennam Gopi1Chaitanya Chaitanya Budagam Haima Naga Venkata2Pottathil Shinu3Borah Pobitra4Venugopala Katharigatta N.5Deb Pran Kishore6Mailavaram Raghu Prasad7Shri Vishnu College of Pharmacy, B.V Raju group of Institutions, Vishnupur, Bhimavaram West Godavari District, Andhra Pradesh 534202IndiaShri Vishnu College of Pharmacy, B.V Raju group of Institutions, Vishnupur, Bhimavaram West Godavari District, Andhra Pradesh 534202IndiaShri Vishnu College of Pharmacy, B.V Raju group of Institutions, Vishnupur, Bhimavaram West Godavari District, Andhra Pradesh 534202IndiaDepartment of Biomedical Sciences, College of Clinical Pharmacy, King Faisal UniversityAl-Ahsa31982, Kingdom of Saudi ArabiaSchool of Pharmacy, Graphic Era Hill UniversityDehradun248002, Uttarakhand, IndiaDepartment of Biotechnology and Food Science Faculty of Applied Sciences, Durban University of Technology, Durban, 4000South AfricaDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Philadelphia University, Amman19392JordanDepartment of Pharmaceutical Chemistry, Shri Ville Parle Kelavani Mandal’s Institute of Pharmacy Survey No. 499, Plot No 03, Mumbai – Agra National Hwy, Behind Gurudwara, Samta Nagar Dhule, Maharashtra424001Malaria is a serious worldwide medical issue that results in substantial annual death and morbidity. The availability of treatment alternatives is limited, and the rise of resistant parasite types has posed a significant challenge to malaria treatment. To prevent a public health disaster, novel antimalarial agents with single-dosage therapies, extensive curative capability, and new mechanisms are urgently needed. There are several approaches to developing antimalarial drugs, ranging from alterations of current drugs to the creation of new compounds with specific targeting abilities. The availability of multiple genomic techniques, as well as recent advancements in parasite biology, provides a varied collection of possible targets for the development of novel treatments. A number of promising pharmacological interference targets have been uncovered in modern times. As a result, our review concentrates on the most current scientific and technical progress in the innovation of new antimalarial medications. The protein kinases, choline transport inhibitors, dihydroorotate dehydrogenase inhibitors, isoprenoid biosynthesis inhibitors, and enzymes involved in the metabolism of lipids and replication of deoxyribonucleic acid, are among the most fascinating antimalarial target proteins presently being investigated. The new cellular targets and drugs which can inhibit malaria and their development techniques are summarised in this study.https://doi.org/10.2478/acph-2023-0001antimalarial drugsprotein kinasesdihydroorotate dehydrogenase |
| spellingShingle | Chinnappanna Naveen Kumar Reddy Yennam Gopi Chaitanya Chaitanya Budagam Haima Naga Venkata Pottathil Shinu Borah Pobitra Venugopala Katharigatta N. Deb Pran Kishore Mailavaram Raghu Prasad Recent approaches in the drug research and development of novel antimalarial drugs with new targets Acta Pharmaceutica antimalarial drugs protein kinases dihydroorotate dehydrogenase |
| title | Recent approaches in the drug research and development of novel antimalarial drugs with new targets |
| title_full | Recent approaches in the drug research and development of novel antimalarial drugs with new targets |
| title_fullStr | Recent approaches in the drug research and development of novel antimalarial drugs with new targets |
| title_full_unstemmed | Recent approaches in the drug research and development of novel antimalarial drugs with new targets |
| title_short | Recent approaches in the drug research and development of novel antimalarial drugs with new targets |
| title_sort | recent approaches in the drug research and development of novel antimalarial drugs with new targets |
| topic | antimalarial drugs protein kinases dihydroorotate dehydrogenase |
| url | https://doi.org/10.2478/acph-2023-0001 |
| work_keys_str_mv | AT chinnappannanaveenkumarreddy recentapproachesinthedrugresearchanddevelopmentofnovelantimalarialdrugswithnewtargets AT yennamgopi recentapproachesinthedrugresearchanddevelopmentofnovelantimalarialdrugswithnewtargets AT chaitanyachaitanyabudagamhaimanagavenkata recentapproachesinthedrugresearchanddevelopmentofnovelantimalarialdrugswithnewtargets AT pottathilshinu recentapproachesinthedrugresearchanddevelopmentofnovelantimalarialdrugswithnewtargets AT borahpobitra recentapproachesinthedrugresearchanddevelopmentofnovelantimalarialdrugswithnewtargets AT venugopalakatharigattan recentapproachesinthedrugresearchanddevelopmentofnovelantimalarialdrugswithnewtargets AT debprankishore recentapproachesinthedrugresearchanddevelopmentofnovelantimalarialdrugswithnewtargets AT mailavaramraghuprasad recentapproachesinthedrugresearchanddevelopmentofnovelantimalarialdrugswithnewtargets |