Predicting Sleeping Disorders After mTBI: A Role for Inflammation and Brain Network Biomarkers
Rui Du,1,* Yue Yu,1– 4,* Xiwen Zhu,2 Ranchao Wang,1 Yu Yang,1 Yang Li,1 Subo Zhang,3 Hui Su4 1Department of Radiology, Zhenjiang First People’s Hospital, Zhenjiang, Jiangsu, People’s Republic of China; 2Department of Surgery, Lishui People’s Hospital, Nanjing, Jiangsu, People...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-06-01
|
| Series: | Journal of Inflammation Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/predicting-sleeping-disorders-after-mtbi-a-role-for-inflammation-and-b-peer-reviewed-fulltext-article-JIR |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849433577902571520 |
|---|---|
| author | Du R Yu Y Zhu X Wang R Yang Y Li Y Zhang S Su H |
| author_facet | Du R Yu Y Zhu X Wang R Yang Y Li Y Zhang S Su H |
| author_sort | Du R |
| collection | DOAJ |
| description | Rui Du,1,* Yue Yu,1– 4,* Xiwen Zhu,2 Ranchao Wang,1 Yu Yang,1 Yang Li,1 Subo Zhang,3 Hui Su4 1Department of Radiology, Zhenjiang First People’s Hospital, Zhenjiang, Jiangsu, People’s Republic of China; 2Department of Surgery, Lishui People’s Hospital, Nanjing, Jiangsu, People’s Republic of China; 3Department of Radiology, The Second People’s Hospital of Lianyungang, Lianyungang, Jiangsu, People’s Republic of China; 4Department of Radiology, Gaoyou People’s Hospital, Yangzhou, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Subo Zhang, Department of Radiology, The Second People’s Hospital of Lianyungang, No. 41 Hailian East Road, Haizhou District, Lianyungang, Jiangsu, People’s Republic of China, Tel +0518-85775003, Email zhangsubolyg@126.com Hui Su, Department of Radiology, Gaoyou People’s Hospital, No. 10, Dongyuan Road, Gaoyou, Jiangsu, People’s Republic of China, Tel +86 18852869930, Email 18852869930@163.comPurpose: To predict the occurrence of sleeping disorders (SD) in patients with mild traumatic brain injury (mTBI) 3 months after injury.Methods: This study recruited a total of 232 patients with mTBI and underwent a three-month follow-up period. Demographic information, MRI images, and inflammatory factor levels were collected one month after injury and PSQI (Pittsburgh Sleep Quality Index) scores were collected three times respectively on admission, 1 month and 3 months after injury. These mTBI patients were divided into those with SD group (mTBI-SD, n=130) and without SD group (mTBI-ND, n=85) based on PSQI score three months after injury. Differential indicators were used to construct univariate and multivariate logistic regression models, and receiver operating characteristic (ROC) curves were plotted. Pearson correlation analysis was conducted to explore the relationship between the differential indicators and PSQI scores.Results: Compared to the mTBI-ND group, patients in the mTBI-SD group exhibited lower levels of OLF.L nodal efficiency, ACG.L nodal efficiency, rich-club connection strength, and feeder connection strength, as well as higher levels of IL-8, IL-10, and TNF-α. In the univariate logistic regression model, OLF.L, ACG.L, rich-club connection strength, IL-8, and TNF-αwere identified as risk factors for the occurrence of SD three months after injury. Their Area Under the Curve (AUC) values were 0.669, 0.589, 0.672, 0.649, and 0.709, respectively. Among them, OLF.L nodal efficiency (78.80%) and rich-club connection strength (76.50%) exhibited higher specificity, while TNF-α (73.82%) demonstrated higher sensitivity. According to the multivariate regression results, the combined model constructed had an ROC-AUC of 0.809, with an accuracy of 75.35%, a sensitivity of 74.62%, and a specificity of 76.47%. The correlation results indicate that OLF.L nodal efficiency, rich-club connection strength and TNF-α are significantly correlated with PSQI scores three months after injury (rOLF.L=− 0.461, rrich-club =− 0.563, rTNF-α=0.538).Conclusion: The logistic regression model and ROC curve based on OLF.L nodal efficiency, rich-club connection strength and TNF-α can effectively predict the occurrence of SD in mTBI patients 3 months after injury.Keywords: mild traumatic brain injury, sleeping disorders, white matter, graph theory, prediction |
| format | Article |
| id | doaj-art-e3800938c95e44b0b4d5823716129d4f |
| institution | Kabale University |
| issn | 1178-7031 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj-art-e3800938c95e44b0b4d5823716129d4f2025-08-20T03:26:57ZengDove Medical PressJournal of Inflammation Research1178-70312025-06-01Volume 18Issue 175857597103782Predicting Sleeping Disorders After mTBI: A Role for Inflammation and Brain Network BiomarkersDu R0Yu Y1Zhu X2Wang R3Yang Y4Li Y5Zhang S6Su H7Department of RadiologyDepartment of Radiology,Department of SurgeryDepartment of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of Radiology,Rui Du,1,* Yue Yu,1– 4,* Xiwen Zhu,2 Ranchao Wang,1 Yu Yang,1 Yang Li,1 Subo Zhang,3 Hui Su4 1Department of Radiology, Zhenjiang First People’s Hospital, Zhenjiang, Jiangsu, People’s Republic of China; 2Department of Surgery, Lishui People’s Hospital, Nanjing, Jiangsu, People’s Republic of China; 3Department of Radiology, The Second People’s Hospital of Lianyungang, Lianyungang, Jiangsu, People’s Republic of China; 4Department of Radiology, Gaoyou People’s Hospital, Yangzhou, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Subo Zhang, Department of Radiology, The Second People’s Hospital of Lianyungang, No. 41 Hailian East Road, Haizhou District, Lianyungang, Jiangsu, People’s Republic of China, Tel +0518-85775003, Email zhangsubolyg@126.com Hui Su, Department of Radiology, Gaoyou People’s Hospital, No. 10, Dongyuan Road, Gaoyou, Jiangsu, People’s Republic of China, Tel +86 18852869930, Email 18852869930@163.comPurpose: To predict the occurrence of sleeping disorders (SD) in patients with mild traumatic brain injury (mTBI) 3 months after injury.Methods: This study recruited a total of 232 patients with mTBI and underwent a three-month follow-up period. Demographic information, MRI images, and inflammatory factor levels were collected one month after injury and PSQI (Pittsburgh Sleep Quality Index) scores were collected three times respectively on admission, 1 month and 3 months after injury. These mTBI patients were divided into those with SD group (mTBI-SD, n=130) and without SD group (mTBI-ND, n=85) based on PSQI score three months after injury. Differential indicators were used to construct univariate and multivariate logistic regression models, and receiver operating characteristic (ROC) curves were plotted. Pearson correlation analysis was conducted to explore the relationship between the differential indicators and PSQI scores.Results: Compared to the mTBI-ND group, patients in the mTBI-SD group exhibited lower levels of OLF.L nodal efficiency, ACG.L nodal efficiency, rich-club connection strength, and feeder connection strength, as well as higher levels of IL-8, IL-10, and TNF-α. In the univariate logistic regression model, OLF.L, ACG.L, rich-club connection strength, IL-8, and TNF-αwere identified as risk factors for the occurrence of SD three months after injury. Their Area Under the Curve (AUC) values were 0.669, 0.589, 0.672, 0.649, and 0.709, respectively. Among them, OLF.L nodal efficiency (78.80%) and rich-club connection strength (76.50%) exhibited higher specificity, while TNF-α (73.82%) demonstrated higher sensitivity. According to the multivariate regression results, the combined model constructed had an ROC-AUC of 0.809, with an accuracy of 75.35%, a sensitivity of 74.62%, and a specificity of 76.47%. The correlation results indicate that OLF.L nodal efficiency, rich-club connection strength and TNF-α are significantly correlated with PSQI scores three months after injury (rOLF.L=− 0.461, rrich-club =− 0.563, rTNF-α=0.538).Conclusion: The logistic regression model and ROC curve based on OLF.L nodal efficiency, rich-club connection strength and TNF-α can effectively predict the occurrence of SD in mTBI patients 3 months after injury.Keywords: mild traumatic brain injury, sleeping disorders, white matter, graph theory, predictionhttps://www.dovepress.com/predicting-sleeping-disorders-after-mtbi-a-role-for-inflammation-and-b-peer-reviewed-fulltext-article-JIRmild traumatic brain injurysleeping disorderswhite mattergraph theoryprediction |
| spellingShingle | Du R Yu Y Zhu X Wang R Yang Y Li Y Zhang S Su H Predicting Sleeping Disorders After mTBI: A Role for Inflammation and Brain Network Biomarkers Journal of Inflammation Research mild traumatic brain injury sleeping disorders white matter graph theory prediction |
| title | Predicting Sleeping Disorders After mTBI: A Role for Inflammation and Brain Network Biomarkers |
| title_full | Predicting Sleeping Disorders After mTBI: A Role for Inflammation and Brain Network Biomarkers |
| title_fullStr | Predicting Sleeping Disorders After mTBI: A Role for Inflammation and Brain Network Biomarkers |
| title_full_unstemmed | Predicting Sleeping Disorders After mTBI: A Role for Inflammation and Brain Network Biomarkers |
| title_short | Predicting Sleeping Disorders After mTBI: A Role for Inflammation and Brain Network Biomarkers |
| title_sort | predicting sleeping disorders after mtbi a role for inflammation and brain network biomarkers |
| topic | mild traumatic brain injury sleeping disorders white matter graph theory prediction |
| url | https://www.dovepress.com/predicting-sleeping-disorders-after-mtbi-a-role-for-inflammation-and-b-peer-reviewed-fulltext-article-JIR |
| work_keys_str_mv | AT dur predictingsleepingdisordersaftermtbiaroleforinflammationandbrainnetworkbiomarkers AT yuy predictingsleepingdisordersaftermtbiaroleforinflammationandbrainnetworkbiomarkers AT zhux predictingsleepingdisordersaftermtbiaroleforinflammationandbrainnetworkbiomarkers AT wangr predictingsleepingdisordersaftermtbiaroleforinflammationandbrainnetworkbiomarkers AT yangy predictingsleepingdisordersaftermtbiaroleforinflammationandbrainnetworkbiomarkers AT liy predictingsleepingdisordersaftermtbiaroleforinflammationandbrainnetworkbiomarkers AT zhangs predictingsleepingdisordersaftermtbiaroleforinflammationandbrainnetworkbiomarkers AT suh predictingsleepingdisordersaftermtbiaroleforinflammationandbrainnetworkbiomarkers |