Advances in thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) biomarkers for autoimmune thyroid diseases
The development of immunological methods in the 1970s and 1980s led to the identification of thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) as key players in the onset of autoimmune thyroid diseases (AITD). TSHR is primarily associated with hyperthyroidism, while TPO is li...
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| Format: | Article |
| Language: | English |
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Indonesian Society for Biochemistry and Molecular Biology
2024-10-01
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| Series: | Acta Biochimica Indonesiana |
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| Online Access: | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/182 |
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| author | Aulanniam Achmad Rudijanto Andreas Budi Wijaya |
| author_facet | Aulanniam Achmad Rudijanto Andreas Budi Wijaya |
| author_sort | Aulanniam |
| collection | DOAJ |
| description |
The development of immunological methods in the 1970s and 1980s led to the identification of thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) as key players in the onset of autoimmune thyroid diseases (AITD). TSHR is primarily associated with hyperthyroidism, while TPO is linked to hypothyroidism. Advances in understanding TPO and TSHR as biomarkers over recent decades have enhanced their clinical application. This review explores the molecular basis of TPO and TSHR as biomarkers, highlighting their importance in diagnosing AITD and their potential to guide effective therapeutic strategies. Additionally, it discusses the development of lateral flow assay (LFA) kits developed by the authors, which show promise as rapid and reliable diagnostic tools for AITD.
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| format | Article |
| id | doaj-art-e37c2a87f9f34317ae3b85e3cf77ba97 |
| institution | Kabale University |
| issn | 2654-6108 2654-3222 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Indonesian Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | Acta Biochimica Indonesiana |
| spelling | doaj-art-e37c2a87f9f34317ae3b85e3cf77ba972025-02-08T03:04:44ZengIndonesian Society for Biochemistry and Molecular BiologyActa Biochimica Indonesiana2654-61082654-32222024-10-017210.32889/actabioina.182Advances in thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) biomarkers for autoimmune thyroid diseases Aulanniam0Achmad Rudijanto1Andreas Budi Wijaya2Department of Chemistry, Faculty of Sciences & Faculty of Veterinary Medicine, Universitas Brawijaya, IndonesiaMetabolic and Endocrinology Division, Department of Internal Medicine of Saiful Anwar General Hospital, Brawijaya University, Malang, East Java, IndonesiaFaculty of Medicine, Universitas Negeri Malang, Malang, East Java, Indonesia The development of immunological methods in the 1970s and 1980s led to the identification of thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) as key players in the onset of autoimmune thyroid diseases (AITD). TSHR is primarily associated with hyperthyroidism, while TPO is linked to hypothyroidism. Advances in understanding TPO and TSHR as biomarkers over recent decades have enhanced their clinical application. This review explores the molecular basis of TPO and TSHR as biomarkers, highlighting their importance in diagnosing AITD and their potential to guide effective therapeutic strategies. Additionally, it discusses the development of lateral flow assay (LFA) kits developed by the authors, which show promise as rapid and reliable diagnostic tools for AITD. https://pbbmi.org/newjurnal/index.php/actabioina/article/view/182TPOTSHRadvanced biomarkersAITDdetection |
| spellingShingle | Aulanniam Achmad Rudijanto Andreas Budi Wijaya Advances in thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) biomarkers for autoimmune thyroid diseases Acta Biochimica Indonesiana TPO TSHR advanced biomarkers AITD detection |
| title | Advances in thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) biomarkers for autoimmune thyroid diseases |
| title_full | Advances in thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) biomarkers for autoimmune thyroid diseases |
| title_fullStr | Advances in thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) biomarkers for autoimmune thyroid diseases |
| title_full_unstemmed | Advances in thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) biomarkers for autoimmune thyroid diseases |
| title_short | Advances in thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) biomarkers for autoimmune thyroid diseases |
| title_sort | advances in thyroid peroxidase tpo and thyroid stimulating hormone receptor tshr biomarkers for autoimmune thyroid diseases |
| topic | TPO TSHR advanced biomarkers AITD detection |
| url | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/182 |
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