Destruction of virus particles via mechanical and chemical virucidal activity of nanocolumnar copper thin films
Human-generated droplets, which facilitate the transmission of viral infections, include large droplets and aerosols. The drying rates of these droplets upon adhesion to a surface vary significantly owing to the wide range of their sizes (∼nine orders of magnitude). Consequently, combating viruses r...
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| Language: | English |
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Elsevier
2025-06-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425003631 |
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| author | Keisuke Shigetoh Yusuke Hirata Nobuhiko Muramoto Nobuhiro Ishida |
| author_facet | Keisuke Shigetoh Yusuke Hirata Nobuhiko Muramoto Nobuhiro Ishida |
| author_sort | Keisuke Shigetoh |
| collection | DOAJ |
| description | Human-generated droplets, which facilitate the transmission of viral infections, include large droplets and aerosols. The drying rates of these droplets upon adhesion to a surface vary significantly owing to the wide range of their sizes (∼nine orders of magnitude). Consequently, combating viruses requires distinct strategies under wet and dry conditions. However, studies that account for these two contrasting conditions are lacking. In the present study, we replicated these conditions and investigated the topographical properties of enveloped bacteriophages as an indicator of viral integrity via high-speed atomic force microscopy. Under wet conditions, a reduction in the virus particle volume was observed only on a nanocolumnar copper (NC-Cu) thin film and not on a chemically stable nanocolumnar cupric oxide (NC-CuO) thin film. In contrast, under dry conditions, virus particles lost their shape integrity on both NC-CuO and NC-Cu films. The deformation of virus particles on the NC-CuO film under dry conditions suggests a mechanism distinct from the chemical activity of Cu (i.e., mechanical activity). These results indicate that dry conditions trigger the mechanical activity of nanostructured surfaces. This highlights the significance of nanostructure-induced mechanical activity in virus inactivation under dry conditions, such as those involving viruses in small droplets or aerosols. |
| format | Article |
| id | doaj-art-e3772dadbbac4ffd992908b641392c57 |
| institution | OA Journals |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-e3772dadbbac4ffd992908b641392c572025-08-20T02:19:47ZengElsevierMaterials Today Bio2590-00642025-06-013210180310.1016/j.mtbio.2025.101803Destruction of virus particles via mechanical and chemical virucidal activity of nanocolumnar copper thin filmsKeisuke Shigetoh0Yusuke Hirata1Nobuhiko Muramoto2Nobuhiro Ishida3Corresponding author.; Toyota Central R&D Labs., Inc., 41-1 Yokomichi, Nagakute, Aichi, 480-1192, JapanToyota Central R&D Labs., Inc., 41-1 Yokomichi, Nagakute, Aichi, 480-1192, JapanToyota Central R&D Labs., Inc., 41-1 Yokomichi, Nagakute, Aichi, 480-1192, JapanToyota Central R&D Labs., Inc., 41-1 Yokomichi, Nagakute, Aichi, 480-1192, JapanHuman-generated droplets, which facilitate the transmission of viral infections, include large droplets and aerosols. The drying rates of these droplets upon adhesion to a surface vary significantly owing to the wide range of their sizes (∼nine orders of magnitude). Consequently, combating viruses requires distinct strategies under wet and dry conditions. However, studies that account for these two contrasting conditions are lacking. In the present study, we replicated these conditions and investigated the topographical properties of enveloped bacteriophages as an indicator of viral integrity via high-speed atomic force microscopy. Under wet conditions, a reduction in the virus particle volume was observed only on a nanocolumnar copper (NC-Cu) thin film and not on a chemically stable nanocolumnar cupric oxide (NC-CuO) thin film. In contrast, under dry conditions, virus particles lost their shape integrity on both NC-CuO and NC-Cu films. The deformation of virus particles on the NC-CuO film under dry conditions suggests a mechanism distinct from the chemical activity of Cu (i.e., mechanical activity). These results indicate that dry conditions trigger the mechanical activity of nanostructured surfaces. This highlights the significance of nanostructure-induced mechanical activity in virus inactivation under dry conditions, such as those involving viruses in small droplets or aerosols.http://www.sciencedirect.com/science/article/pii/S2590006425003631Antiviral coatingsHigh-speed atomic force microscopyImage analysisNanostructuresAerosolsBacteriophage |
| spellingShingle | Keisuke Shigetoh Yusuke Hirata Nobuhiko Muramoto Nobuhiro Ishida Destruction of virus particles via mechanical and chemical virucidal activity of nanocolumnar copper thin films Materials Today Bio Antiviral coatings High-speed atomic force microscopy Image analysis Nanostructures Aerosols Bacteriophage |
| title | Destruction of virus particles via mechanical and chemical virucidal activity of nanocolumnar copper thin films |
| title_full | Destruction of virus particles via mechanical and chemical virucidal activity of nanocolumnar copper thin films |
| title_fullStr | Destruction of virus particles via mechanical and chemical virucidal activity of nanocolumnar copper thin films |
| title_full_unstemmed | Destruction of virus particles via mechanical and chemical virucidal activity of nanocolumnar copper thin films |
| title_short | Destruction of virus particles via mechanical and chemical virucidal activity of nanocolumnar copper thin films |
| title_sort | destruction of virus particles via mechanical and chemical virucidal activity of nanocolumnar copper thin films |
| topic | Antiviral coatings High-speed atomic force microscopy Image analysis Nanostructures Aerosols Bacteriophage |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425003631 |
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