Krüppel-like factor 4 control of immune cell function
Krüppel-like factor 4 (KLF4) belongs to a family of transcription factors that contain conserved zinc finger DNA binding domains, including specificity proteins (SPs) and Krüppel-like factors (KLFs). KLF4 plays a vital role in regulating cellular differentiation, proliferation and adaptation to a br...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1597210/full |
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| author | Tapatee Das Elaine Wang Yitian Xu Harrison Yang Xudong Liao Mukesh K. Jain Mukesh K. Jain |
| author_facet | Tapatee Das Elaine Wang Yitian Xu Harrison Yang Xudong Liao Mukesh K. Jain Mukesh K. Jain |
| author_sort | Tapatee Das |
| collection | DOAJ |
| description | Krüppel-like factor 4 (KLF4) belongs to a family of transcription factors that contain conserved zinc finger DNA binding domains, including specificity proteins (SPs) and Krüppel-like factors (KLFs). KLF4 plays a vital role in regulating cellular differentiation, proliferation and adaptation to a broad spectrum of internal and external cues. In the context of the immunity, KLF4 is appreciated as critical to both the innate and adaptive arms of the immune system. The current review article focuses on these aspects of KLF4 action as well as implications of this work for impacting human health. |
| format | Article |
| id | doaj-art-e374c54c132040e8aee8eaffbe3063f4 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-e374c54c132040e8aee8eaffbe3063f42025-08-20T03:42:44ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-08-011610.3389/fimmu.2025.15972101597210Krüppel-like factor 4 control of immune cell functionTapatee Das0Elaine Wang1Yitian Xu2Harrison Yang3Xudong Liao4Mukesh K. Jain5Mukesh K. Jain6Department of Molecular Biology, Cell Biology & Biochemistry, Division of Biology and Medicine, Brown University, Providence, RI, United StatesDepartment of Molecular Biology, Cell Biology & Biochemistry, Division of Biology and Medicine, Brown University, Providence, RI, United StatesDepartment of Molecular Biology, Cell Biology & Biochemistry, Division of Biology and Medicine, Brown University, Providence, RI, United StatesDepartment of Molecular Biology, Cell Biology & Biochemistry, Division of Biology and Medicine, Brown University, Providence, RI, United StatesDepartment of Molecular Biology, Cell Biology & Biochemistry, Division of Biology and Medicine, Brown University, Providence, RI, United StatesDepartment of Molecular Biology, Cell Biology & Biochemistry, Division of Biology and Medicine, Brown University, Providence, RI, United StatesThe Warren Alpert Medical School, Brown University, Providence, RI, United StatesKrüppel-like factor 4 (KLF4) belongs to a family of transcription factors that contain conserved zinc finger DNA binding domains, including specificity proteins (SPs) and Krüppel-like factors (KLFs). KLF4 plays a vital role in regulating cellular differentiation, proliferation and adaptation to a broad spectrum of internal and external cues. In the context of the immunity, KLF4 is appreciated as critical to both the innate and adaptive arms of the immune system. The current review article focuses on these aspects of KLF4 action as well as implications of this work for impacting human health.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1597210/fullKLF4immune cellsinnate & adaptive immune responseSP familyhomeostasis |
| spellingShingle | Tapatee Das Elaine Wang Yitian Xu Harrison Yang Xudong Liao Mukesh K. Jain Mukesh K. Jain Krüppel-like factor 4 control of immune cell function Frontiers in Immunology KLF4 immune cells innate & adaptive immune response SP family homeostasis |
| title | Krüppel-like factor 4 control of immune cell function |
| title_full | Krüppel-like factor 4 control of immune cell function |
| title_fullStr | Krüppel-like factor 4 control of immune cell function |
| title_full_unstemmed | Krüppel-like factor 4 control of immune cell function |
| title_short | Krüppel-like factor 4 control of immune cell function |
| title_sort | kruppel like factor 4 control of immune cell function |
| topic | KLF4 immune cells innate & adaptive immune response SP family homeostasis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1597210/full |
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