Activation of cannabinoid CB1 receptors suppresses HCN channels function in dorsal root ganglion neurons of rats

Activation of cannabinoid CB1 receptors suppresses HCN channels function in dorsal root ganglion neurons of rats

Cannabinoid receptor (CBR) and hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are both critically involved in pain hypersensitivity induced by nerve injury. Both CBR and HCN channels are expressed in sensory neurons of the dorsal root ganglia (DRG). Studies have shown that HCN ch...

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Bibliographic Details
Main Authors: Xiaolu Lei, Meiyun Chen, Xingfeng Liu, Yan Yan, Xupeng Li, Fei Gong, Deqian Yu, Xiaohong Liu
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Brain Research Bulletin
Subjects:
Neuropathic pain
Cannabinoid receptor 1
HCN channels
cAMP
Dorsal root ganglia
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923025002370
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