Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network
Objectives In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greate...
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2021-04-01
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| Series: | Lupus Science and Medicine |
| Online Access: | https://lupus.bmj.com/content/8/1/e000522.full |
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| author | Richard A Furie Andrew Filer Michael H Weisman Judith A James Kenneth Kalunian Chaim Putterman H Michael Belmont Ilfita Sahbudin Karim Raza Maria Dall'Era Jill P Buyon Diane L Kamen Karen Salomon-Escoto Kazuyoshi Ishigaki Patrick Dunn Betty Diamond David Wofsy Michele Bombardieri Vivian Bykerk Ming Wu Soumya Raychaudhuri Hemant Suryawanshi Thomas Tuschl Christopher Ritchlin Maureen McMahon Jennifer Grossman Philip M Carlucci Alessandra Nerviani Peter M Izmirly Fan Zhang Felice Rivellese Joan Bathon Zhu Zhu Qian Xiao Jessica Li Holden Maecker Nir Hacohen Jennifer Anolik Javier Rangel-Moreno Nida Meednu Susan Goodman Lindsy Forbess Mariko Ishimori Kevin Deane David Hildeman Yuhong Li Robert Clancy ANNE DAVIDSON Matthias Kretzler Larry Moreland Harris Perlman Peter Gregersen Celine C Berthier Andrea Fava David Boyle Derek M Fine Ami Ben-Artzi P J Utz Melanie Smith Beatrice Goilav Carla Cuda Andrew McDavid Joshua Keegan Ilya Korsunsky Joel Guthridge Kevin Wei Arnon Arazi Thomas Eisenhaure Michael Brenner Susan Macwana Pavel Morozov Manjunath Kustagi Gerald Watts Kristina K Deonaraine Jose Monroy-Trujillo Mohamed G Atta Kristin Haag William Apruzzese Sean Connery Fernanda Payan-Schober Kerry Cho Jennifer Goff Aparna Nathan Joseph Mears Nghia Millard Kathryn Weinand Saori Sakaue Bill Robinson Wade DeJager Louis Bridges Laura Donlin Edward DiCarlo Amit Lakhanpal Heather Sherman Anvita Singaraju Lorien Shakib Brendan Boyce Darren Tabechian Jen Albrecht James Lederer A Helena Jonsson Daimon Simmons Gregory Keras Adam Chicoine Zhihan Jian Li Mandy McGeachy Gary Firestein Arnold Ceponis Diane Horowitz Salina Dominguez Arthur Mandelin Anjali Thakrar Mike Holers Jennifer Seifert Constanino Pitzalis Ellen Gravallese Jennifer Barnas Raymond Hsu Steven Woodle Paul Hoover Michael Peters Tony Jones David Lieb Jeffrey Hodgin Raji Menon |
| author_facet | Richard A Furie Andrew Filer Michael H Weisman Judith A James Kenneth Kalunian Chaim Putterman H Michael Belmont Ilfita Sahbudin Karim Raza Maria Dall'Era Jill P Buyon Diane L Kamen Karen Salomon-Escoto Kazuyoshi Ishigaki Patrick Dunn Betty Diamond David Wofsy Michele Bombardieri Vivian Bykerk Ming Wu Soumya Raychaudhuri Hemant Suryawanshi Thomas Tuschl Christopher Ritchlin Maureen McMahon Jennifer Grossman Philip M Carlucci Alessandra Nerviani Peter M Izmirly Fan Zhang Felice Rivellese Joan Bathon Zhu Zhu Qian Xiao Jessica Li Holden Maecker Nir Hacohen Jennifer Anolik Javier Rangel-Moreno Nida Meednu Susan Goodman Lindsy Forbess Mariko Ishimori Kevin Deane David Hildeman Yuhong Li Robert Clancy ANNE DAVIDSON Matthias Kretzler Larry Moreland Harris Perlman Peter Gregersen Celine C Berthier Andrea Fava David Boyle Derek M Fine Ami Ben-Artzi P J Utz Melanie Smith Beatrice Goilav Carla Cuda Andrew McDavid Joshua Keegan Ilya Korsunsky Joel Guthridge Kevin Wei Arnon Arazi Thomas Eisenhaure Michael Brenner Susan Macwana Pavel Morozov Manjunath Kustagi Gerald Watts Kristina K Deonaraine Jose Monroy-Trujillo Mohamed G Atta Kristin Haag William Apruzzese Sean Connery Fernanda Payan-Schober Kerry Cho Jennifer Goff Aparna Nathan Joseph Mears Nghia Millard Kathryn Weinand Saori Sakaue Bill Robinson Wade DeJager Louis Bridges Laura Donlin Edward DiCarlo Amit Lakhanpal Heather Sherman Anvita Singaraju Lorien Shakib Brendan Boyce Darren Tabechian Jen Albrecht James Lederer A Helena Jonsson Daimon Simmons Gregory Keras Adam Chicoine Zhihan Jian Li Mandy McGeachy Gary Firestein Arnold Ceponis Diane Horowitz Salina Dominguez Arthur Mandelin Anjali Thakrar Mike Holers Jennifer Seifert Constanino Pitzalis Ellen Gravallese Jennifer Barnas Raymond Hsu Steven Woodle Paul Hoover Michael Peters Tony Jones David Lieb Jeffrey Hodgin Raji Menon |
| author_sort | Richard A Furie |
| collection | DOAJ |
| description | Objectives In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greater dissection of the pathways to tissue inflammation and injury. This study assessed the safety of kidney biopsies in patients with SLE enrolled in the Accelerating Medicines Partnership, a consortium formed to molecularly deconstruct nephritis.Methods 475 patients with SLE across 15 clinical sites in the USA consented to obtain tissue for research purposes during a clinically indicated kidney biopsy. Adverse events (AEs) were documented for 30 days following the procedure and were determined to be related or unrelated by all site investigators. Serious AEs were defined according to the National Institutes of Health reporting guidelines.Results 34 patients (7.2%) experienced a procedure-related AE: 30 with haematoma, 2 with jets, 1 with pain and 1 with an arteriovenous fistula. Eighteen (3.8%) experienced a serious AE requiring hospitalisation; four patients (0.8%) required a blood transfusion related to the kidney biopsy. At one site where the number of cores retrieved during the biopsy was recorded, the mean was 3.4 for those who experienced a related AE (n=9) and 3.07 for those who did not experience any AE (n=140). All related AEs resolved.Conclusions Procurement of research tissue should be considered feasible, accompanied by a complication risk likely no greater than that incurred for standard clinical purposes. In the quest for targeted treatments personalised based on molecular findings, enhanced diagnostics beyond histology will likely be required. |
| format | Article |
| id | doaj-art-e3722c73b6ce45bba6e56c13af3b5745 |
| institution | OA Journals |
| issn | 2053-8790 |
| language | English |
| publishDate | 2021-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Lupus Science and Medicine |
| spelling | doaj-art-e3722c73b6ce45bba6e56c13af3b57452025-08-20T02:36:35ZengBMJ Publishing GroupLupus Science and Medicine2053-87902021-04-018110.1136/lupus-2021-000522Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE NetworkRichard A Furie0Andrew Filer1Michael H Weisman2Judith A James3Kenneth Kalunian4Chaim Putterman5H Michael Belmont6Ilfita Sahbudin7Karim Raza8Maria Dall'Era9Jill P Buyon10Diane L Kamen11Karen Salomon-EscotoKazuyoshi Ishigaki12Patrick DunnBetty Diamond13David Wofsy14Michele Bombardieri15Vivian Bykerk16Ming Wu17Soumya RaychaudhuriHemant SuryawanshiThomas TuschlChristopher RitchlinMaureen McMahon18Jennifer Grossman19Philip M Carlucci20Alessandra Nerviani21Peter M Izmirly22Fan Zhang23Felice Rivellese24Joan Bathon25Zhu Zhu26Qian Xiao27Jessica Li28Holden MaeckerNir Hacohen29Jennifer Anolik30Javier Rangel-Moreno31Nida Meednu32Susan Goodman33Lindsy Forbess34Mariko Ishimori35Kevin Deane36David Hildeman37Yuhong LiRobert Clancy38ANNE DAVIDSON39Matthias Kretzler40Larry Moreland41Harris Perlman42Peter GregersenCeline C Berthier43Andrea Fava44David BoyleDerek M Fine45Ami Ben-ArtziP J UtzMelanie Smith46Beatrice GoilavCarla Cuda47Andrew McDavidJoshua KeeganIlya KorsunskyJoel Guthridge48Kevin Wei49Arnon Arazi50Thomas EisenhaureMichael Brenner51Susan MacwanaPavel MorozovManjunath KustagiGerald WattsKristina K Deonaraine52Jose Monroy-Trujillo53Mohamed G Atta54Kristin Haag55William Apruzzese56Sean Connery57Fernanda Payan-Schober58Kerry Cho59Jennifer Goff60Aparna NathanJoseph MearsNghia MillardKathryn WeinandSaori SakaueBill RobinsonWade DeJagerLouis BridgesLaura Donlin61Edward DiCarloAmit Lakhanpal62Heather ShermanAnvita SingarajuLorien ShakibBrendan Boyce63Darren TabechianJen AlbrechtJames LedererA Helena JonssonDaimon SimmonsGregory KerasAdam ChicoineZhihan Jian LiMandy McGeachyGary FiresteinArnold CeponisDiane HorowitzSalina Dominguez64Arthur Mandelin65Anjali ThakrarMike HolersJennifer Seifert66Constanino PitzalisEllen GravalleseJennifer BarnasRaymond HsuSteven WoodlePaul HooverMichael PetersTony JonesDavid LiebJeffrey Hodgin67Raji MenonDivision of Rheumatology, Northwell Health, Great Neck, New York, USA2Rheumatoid Arthritis Pathogenesis Centre of Excellence (RACE), Glasgow, Birmingham, Newcastle., Glasgow, United KingdomDepartment of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USAArthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA9University of California, San Diego, La Jolla, United States of AmericaDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA2 Rheumatology, NYU Grossman School of Medicine, New York City, New York, USAInstitute of Inflammation and Ageing, University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom3NIHR Birmingham Biomedical Research Centre, Birmingham, United KingdomUniversity of California San Francisco, San Francisco, California, USADepartment of Medicine, NYU Grossman School of Medicine, New York City, New York, USAMedical University of South Carolina, Charleston, South Carolina, USALaboratory for Human Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan8The Feinstein Institute for Medical Research, Manhasset, United States of America7UCSF Medical Center, San Francisco, United States of AmericaCentre for Experimental Medicine and Rheumatology, William Harvey Research Institute, London, UKHospital for Special Surgery, New York, NY, United States of America1 Department of Thoracic Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine,Zhejiang University, Hangzhou, Zhejiang Province, People`s Republic of ChinaMedicine - Rheumatology, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA13University of California, Los Angeles CA, United States of AmericaDivision of Rheumatology, New York University Grossman School of Medicine, New York, NY, USA1William Harvey Research Institute, Queen Mary University of London, UK, Centre for Experimental Medicine and Rheumatology, London, United KingdomDepartment of Medicine, NYU Grossman School of Medicine, New York City, New York, USADepartment of Pathophysiology, Guizhou Medical University, Guiyang, ChinaQueen Mary University of London – William Harvey Research Institute, Centre for Experimental Medicine and Rheumatology, London, United Kingdom2 Columbia University Medical Center, New York, New York, USA1 Department of Neurology, University of California Irvine, Irvine, California, USA1 Mental Health Center, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDivision of Rheumatology, Johns Hopkins University, Baltimore, MD, USA3Harvard Medical School, Boston, United States of AmericaDepartment of Medicine, Division of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, USA1University of Rochester School of Medicine, Division of Allergy, Immunology and Rheumatology, Rochester, United States of America1University of Rochester School of Medicine, Division of Allergy, Immunology and Rheumatology, Rochester, United States of America2Hospital for Special Surgery, Weill Cornell Medicine, Rheumatology, New York, United States of AmericaRheumatology, Cedars-Sinai Medical Center, Los Angeles, California, USADepartment of Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California, USA5 The Open University, Milton Keynes, UK10University of Cincinnati, Cincinnati, United States of AmericaDivision of Rheumatology, Department of Medicine, New York University School of Medicine, New York City, New York, USA8The Feinstein Institute for Medical Research, Manhasset, United States of America9University of Michigan, Ann Arbor, United States of AmericaOrthopedics, University of Colorado, Denver, Colorado, USANorthwestern University, Medicine/Rheumatology, Chicago, United States of AmericaInternal Medicine, Department of Nephrology, University of Michigan, Ann Arbor, MI, USA1Johns Hopkins University, Baltimore, United States of AmericaDivision of Nephrology, Johns Hopkins University, Baltimore, MD, USAclinical psychologistNorthwestern University, Medicine/Rheumatology, Chicago, United States of America1Oklahoma Medical Research Foundation, Arthritis and Clinical Immunology, Oklahoma City, United States of AmericaDepartment of Medicine, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA4Broad Institute, Cambridge, United States of AmericaBrigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States of AmericaDivision of Rheumatology, New York University Grossman School of Medicine, New York, NY, USA11Nephrology, Johns Hopkins University, USA11Nephrology, Johns Hopkins University, USADivision of Rheumatology, Johns Hopkins University, Baltimore, MD, USA9Division of Rheumatology, Immunology, Allergy, Department of Medicine, Brigham and Women’s Hospital, Boston, USADepartment of Internal Medicine, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USADepartment of Internal Medicine, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USANephrology Division, University of California San Francisco, San Francisco, CA, USAAuthorWeill Cornell Medical College, Department of Medicine, New York, NY, United States of AmericaDepartment of Medicine, Division of Rheumatology, Hospital for Special Surgery, New York, New York, USA8 Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USANorthwestern University, Medicine/Rheumatology, Chicago, United States of AmericaNorthwestern University, Medicine/Rheumatology, Chicago, United States of AmericaCU Anschutz Medical Campus, Aurora, United States of America3Pathology, University of Michigan, USAObjectives In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greater dissection of the pathways to tissue inflammation and injury. This study assessed the safety of kidney biopsies in patients with SLE enrolled in the Accelerating Medicines Partnership, a consortium formed to molecularly deconstruct nephritis.Methods 475 patients with SLE across 15 clinical sites in the USA consented to obtain tissue for research purposes during a clinically indicated kidney biopsy. Adverse events (AEs) were documented for 30 days following the procedure and were determined to be related or unrelated by all site investigators. Serious AEs were defined according to the National Institutes of Health reporting guidelines.Results 34 patients (7.2%) experienced a procedure-related AE: 30 with haematoma, 2 with jets, 1 with pain and 1 with an arteriovenous fistula. Eighteen (3.8%) experienced a serious AE requiring hospitalisation; four patients (0.8%) required a blood transfusion related to the kidney biopsy. At one site where the number of cores retrieved during the biopsy was recorded, the mean was 3.4 for those who experienced a related AE (n=9) and 3.07 for those who did not experience any AE (n=140). All related AEs resolved.Conclusions Procurement of research tissue should be considered feasible, accompanied by a complication risk likely no greater than that incurred for standard clinical purposes. In the quest for targeted treatments personalised based on molecular findings, enhanced diagnostics beyond histology will likely be required.https://lupus.bmj.com/content/8/1/e000522.full |
| spellingShingle | Richard A Furie Andrew Filer Michael H Weisman Judith A James Kenneth Kalunian Chaim Putterman H Michael Belmont Ilfita Sahbudin Karim Raza Maria Dall'Era Jill P Buyon Diane L Kamen Karen Salomon-Escoto Kazuyoshi Ishigaki Patrick Dunn Betty Diamond David Wofsy Michele Bombardieri Vivian Bykerk Ming Wu Soumya Raychaudhuri Hemant Suryawanshi Thomas Tuschl Christopher Ritchlin Maureen McMahon Jennifer Grossman Philip M Carlucci Alessandra Nerviani Peter M Izmirly Fan Zhang Felice Rivellese Joan Bathon Zhu Zhu Qian Xiao Jessica Li Holden Maecker Nir Hacohen Jennifer Anolik Javier Rangel-Moreno Nida Meednu Susan Goodman Lindsy Forbess Mariko Ishimori Kevin Deane David Hildeman Yuhong Li Robert Clancy ANNE DAVIDSON Matthias Kretzler Larry Moreland Harris Perlman Peter Gregersen Celine C Berthier Andrea Fava David Boyle Derek M Fine Ami Ben-Artzi P J Utz Melanie Smith Beatrice Goilav Carla Cuda Andrew McDavid Joshua Keegan Ilya Korsunsky Joel Guthridge Kevin Wei Arnon Arazi Thomas Eisenhaure Michael Brenner Susan Macwana Pavel Morozov Manjunath Kustagi Gerald Watts Kristina K Deonaraine Jose Monroy-Trujillo Mohamed G Atta Kristin Haag William Apruzzese Sean Connery Fernanda Payan-Schober Kerry Cho Jennifer Goff Aparna Nathan Joseph Mears Nghia Millard Kathryn Weinand Saori Sakaue Bill Robinson Wade DeJager Louis Bridges Laura Donlin Edward DiCarlo Amit Lakhanpal Heather Sherman Anvita Singaraju Lorien Shakib Brendan Boyce Darren Tabechian Jen Albrecht James Lederer A Helena Jonsson Daimon Simmons Gregory Keras Adam Chicoine Zhihan Jian Li Mandy McGeachy Gary Firestein Arnold Ceponis Diane Horowitz Salina Dominguez Arthur Mandelin Anjali Thakrar Mike Holers Jennifer Seifert Constanino Pitzalis Ellen Gravallese Jennifer Barnas Raymond Hsu Steven Woodle Paul Hoover Michael Peters Tony Jones David Lieb Jeffrey Hodgin Raji Menon Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network Lupus Science and Medicine |
| title | Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network |
| title_full | Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network |
| title_fullStr | Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network |
| title_full_unstemmed | Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network |
| title_short | Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network |
| title_sort | safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus data from the accelerating medicines partnership ra sle network |
| url | https://lupus.bmj.com/content/8/1/e000522.full |
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