The REFRACT trial: implementation of Bayesian power priors in a randomised, sequential phase II adaptive platform trial

The REFRACT trial: implementation of Bayesian power priors in a randomised, sequential phase II adaptive platform trial

Abstract Background REFRACT is a randomised trial aimed at rapidly evaluating multiple novel therapies against standard treatment for relapsed or refractory follicular lymphoma (rrFL) using a minimal number of patients. To this end, we designed a prospective, adaptive, sequentially randomised clinic...

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Bibliographic Details
Main Authors: Charlotte Gaskell, Kim Linton, Mark Bishton, Graham McIlroy, Siân Lax, Sonia Fox, Louise Hopkins, Rebecca Collings, Malcolm Rhodes, Tania Seale, Aimee Jackson
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Medical Research Methodology
Subjects:
Bayesian
Power priors
Trial design
Novel therapies
Follicular lymphoma
Online Access:https://doi.org/10.1186/s12874-025-02575-5
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