A study of the Interaction Between Cetirizine and Plasma Membrane of Eosinophils, Neutrophils, Platelets and Lymphocytes using A fluorescence Technique
The effect of cetirizine on plasma membrane fluidity and heterogeneity of human eosinophils, neutrophils, platelets and lymphocytes was investigated using a fluorescence technique. Membrane fluidity and heterogeneity were studied by measuring the steady-state fluorescence anisotropy and fluorescence...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000335 |
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| Summary: | The effect of cetirizine on plasma membrane fluidity and
heterogeneity of human eosinophils, neutrophils, platelets and
lymphocytes was investigated using a fluorescence technique.
Membrane fluidity and heterogeneity were studied by measuring the
steady-state fluorescence anisotropy and fluorescence decay of 1-(4-
trimethylammonium-phenyl)-6-phenyl-1, 3, 5-hexatriene (TMA-DPH)
incorporated in the membrane. The results demonstrate that
cetirizine (1 μg/ml) induced a significant increase in the
Hpid order in the exterior part of the membrane and a decrease in
membrane heterogeneity in eosinophils, neutrophils and platelets.
Moreover, cetirizine blocked the PAF induced changes in membrane
fluidity in these cells. Cetirizine did not influence significantly
the plasma membrane of lymphocytes. These data may partially explain
the effect ofcetirizine on inflammatory cell activities. |
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| ISSN: | 0962-9351 1466-1861 |