Innovation in Osteogenesis Activation: Role of Marine-Derived Materials in Bone Regeneration

Marine-derived biomaterials are emerging as promising candidates for tissue regeneration due to their sustainability, biocompatibility, bioactivity, and unique chemical structure. This review provides an overview of different marine-derived inorganic and organic materials, such as calcium carbonate,...

Full description

Saved in:
Bibliographic Details
Main Authors: Maria Giovanna Rizzo, Marilena Briglia, Vincenzo Zammuto, Dario Morganti, Caterina Faggio, Federica Impellitteri, Cristiana Roberta Multisanti, Adriana Carol Eleonora Graziano
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Current Issues in Molecular Biology
Subjects:
Online Access:https://www.mdpi.com/1467-3045/47/3/175
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1850204557512015872
author Maria Giovanna Rizzo
Marilena Briglia
Vincenzo Zammuto
Dario Morganti
Caterina Faggio
Federica Impellitteri
Cristiana Roberta Multisanti
Adriana Carol Eleonora Graziano
author_facet Maria Giovanna Rizzo
Marilena Briglia
Vincenzo Zammuto
Dario Morganti
Caterina Faggio
Federica Impellitteri
Cristiana Roberta Multisanti
Adriana Carol Eleonora Graziano
author_sort Maria Giovanna Rizzo
collection DOAJ
description Marine-derived biomaterials are emerging as promising candidates for tissue regeneration due to their sustainability, biocompatibility, bioactivity, and unique chemical structure. This review provides an overview of different marine-derived inorganic and organic materials, such as calcium carbonate, magnesium salts, silica, polysaccharides, bioactive peptides, and lipid-based compounds, and their effects in promoting osteogenesis. Specifically, the osteoinductive, osteoconductive, and osteointegrative activities of traditional and innovative materials that influence key molecular pathways such as BMP/Smad and Wnt/β-catenin signaling underlying bone formation will be evaluated. This review also prospects innovative approaches, i.e., phage display technology, to optimize marine-derived peptides for targeted bone regeneration. In the context of innovative and sustainable materials, this review suggests some interesting applications of unusual materials able to overcome the limitations of conventional ones and stimulate cellular regeneration of bone tissue by activating specific molecular pathways.
format Article
id doaj-art-e36bddc1975847c28634aa295e7e8a4f
institution OA Journals
issn 1467-3037
1467-3045
language English
publishDate 2025-03-01
publisher MDPI AG
record_format Article
series Current Issues in Molecular Biology
spelling doaj-art-e36bddc1975847c28634aa295e7e8a4f2025-08-20T02:11:16ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-03-0147317510.3390/cimb47030175Innovation in Osteogenesis Activation: Role of Marine-Derived Materials in Bone RegenerationMaria Giovanna Rizzo0Marilena Briglia1Vincenzo Zammuto2Dario Morganti3Caterina Faggio4Federica Impellitteri5Cristiana Roberta Multisanti6Adriana Carol Eleonora Graziano7Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d’Alcontres, 31, 98166 Messina, ItalyDepartment of Medicine and Surgery, “Kore” University of Enna, 94100 Enna, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d’Alcontres, 31, 98166 Messina, ItalyConsiglio Nazionale delle Ricerche DSFTM, Department of Physical Sciences and Technologies of Matter, Piazzale Aldo Moro, 7, 00185 Roma, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d’Alcontres, 31, 98166 Messina, ItalyDepartment of Veterinary Sciences, University of Messina, Viale Giovanni Palatucci, 98168 Messina, ItalyDepartment of Veterinary Sciences, University of Messina, Viale Giovanni Palatucci, 98168 Messina, ItalyDepartment of Medicine and Surgery, “Kore” University of Enna, 94100 Enna, ItalyMarine-derived biomaterials are emerging as promising candidates for tissue regeneration due to their sustainability, biocompatibility, bioactivity, and unique chemical structure. This review provides an overview of different marine-derived inorganic and organic materials, such as calcium carbonate, magnesium salts, silica, polysaccharides, bioactive peptides, and lipid-based compounds, and their effects in promoting osteogenesis. Specifically, the osteoinductive, osteoconductive, and osteointegrative activities of traditional and innovative materials that influence key molecular pathways such as BMP/Smad and Wnt/β-catenin signaling underlying bone formation will be evaluated. This review also prospects innovative approaches, i.e., phage display technology, to optimize marine-derived peptides for targeted bone regeneration. In the context of innovative and sustainable materials, this review suggests some interesting applications of unusual materials able to overcome the limitations of conventional ones and stimulate cellular regeneration of bone tissue by activating specific molecular pathways.https://www.mdpi.com/1467-3045/47/3/175bone tissue regenerationmarine biomaterialseco-physiologyblue biotechnologiesmolecular pathwaysmarine ecology
spellingShingle Maria Giovanna Rizzo
Marilena Briglia
Vincenzo Zammuto
Dario Morganti
Caterina Faggio
Federica Impellitteri
Cristiana Roberta Multisanti
Adriana Carol Eleonora Graziano
Innovation in Osteogenesis Activation: Role of Marine-Derived Materials in Bone Regeneration
Current Issues in Molecular Biology
bone tissue regeneration
marine biomaterials
eco-physiology
blue biotechnologies
molecular pathways
marine ecology
title Innovation in Osteogenesis Activation: Role of Marine-Derived Materials in Bone Regeneration
title_full Innovation in Osteogenesis Activation: Role of Marine-Derived Materials in Bone Regeneration
title_fullStr Innovation in Osteogenesis Activation: Role of Marine-Derived Materials in Bone Regeneration
title_full_unstemmed Innovation in Osteogenesis Activation: Role of Marine-Derived Materials in Bone Regeneration
title_short Innovation in Osteogenesis Activation: Role of Marine-Derived Materials in Bone Regeneration
title_sort innovation in osteogenesis activation role of marine derived materials in bone regeneration
topic bone tissue regeneration
marine biomaterials
eco-physiology
blue biotechnologies
molecular pathways
marine ecology
url https://www.mdpi.com/1467-3045/47/3/175
work_keys_str_mv AT mariagiovannarizzo innovationinosteogenesisactivationroleofmarinederivedmaterialsinboneregeneration
AT marilenabriglia innovationinosteogenesisactivationroleofmarinederivedmaterialsinboneregeneration
AT vincenzozammuto innovationinosteogenesisactivationroleofmarinederivedmaterialsinboneregeneration
AT dariomorganti innovationinosteogenesisactivationroleofmarinederivedmaterialsinboneregeneration
AT caterinafaggio innovationinosteogenesisactivationroleofmarinederivedmaterialsinboneregeneration
AT federicaimpellitteri innovationinosteogenesisactivationroleofmarinederivedmaterialsinboneregeneration
AT cristianarobertamultisanti innovationinosteogenesisactivationroleofmarinederivedmaterialsinboneregeneration
AT adrianacaroleleonoragraziano innovationinosteogenesisactivationroleofmarinederivedmaterialsinboneregeneration