Long-term resident adipose-derived stromal stem cells in the microenvironment remodeling BLCA cell stemness and EMT promotes bladder cancer progression

Long-term resident adipose-derived stromal stem cells in the microenvironment remodeling BLCA cell stemness and EMT promotes bladder cancer progression

Abstract The role of adipose-derived stromal stem cells (ADSCs) in BLCA progression is unclear. We investigated the effects of invasion, stemness, Epithelial-mesenchymal transition (EMT), and drug resistance of BLCA cells co-cultured with ADSCs for a long period of time. Cells were divided into six...

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Bibliographic Details
Main Authors: Denggao Huang, Na Guo, Yanling Peng, Zhenyu Nie, Yuanhui Gao, Hui Cao, Shunlan Wang, Mei Chen, Xiaohong Wen, Zhaojun Wang, Linlin Zheng, Haowei He, Yong Sun, Yang Chen, Shufang Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Adipose-derived stromal stem cells
Bladder cancer
Stemness
Epithelial mesenchymal transition
Invasion
Drug resistance
Online Access:https://doi.org/10.1038/s41598-025-07387-7
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