Toward the consensus of definitions for the phenomena of antifungal tolerance and persistence in filamentous fungi
ABSTRACT Antifungal drug tolerance and persistence are being increasingly recognized in fungal pathogens. Accordingly, more and more research is being carried out to characterize and understand these phenomena. However, the terminology and methodology employed in the fungal community lack consensus,...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2025-04-01
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| Series: | mBio |
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| Online Access: | https://journals.asm.org/doi/10.1128/mbio.03475-24 |
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| author | Jorge Amich Michael Bromley Gustavo H. Goldman Clara Valero |
| author_facet | Jorge Amich Michael Bromley Gustavo H. Goldman Clara Valero |
| author_sort | Jorge Amich |
| collection | DOAJ |
| description | ABSTRACT Antifungal drug tolerance and persistence are being increasingly recognized in fungal pathogens. Accordingly, more and more research is being carried out to characterize and understand these phenomena. However, the terminology and methodology employed in the fungal community lack consensus, particularly for filamentous fungi, as they present further complexities when compared to single-celled microorganisms. Hence, with the aim to ensure consistency in the literature, in this Perspective article, we propose tailored definitions for tolerance and persistence in filamentous fungi and suggest methods to detect and investigate these phenomena in the laboratory. |
| format | Article |
| id | doaj-art-e3657cc1a66c4d71ad20a4935bb7827c |
| institution | OA Journals |
| issn | 2150-7511 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj-art-e3657cc1a66c4d71ad20a4935bb7827c2025-08-20T02:16:44ZengAmerican Society for MicrobiologymBio2150-75112025-04-0116410.1128/mbio.03475-24Toward the consensus of definitions for the phenomena of antifungal tolerance and persistence in filamentous fungiJorge Amich0Michael Bromley1Gustavo H. Goldman2Clara Valero3Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III (ISCIII), Madrid, SpainManchester Fungal Infection Group (MFIG), Division of Evolution, Infection, and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United KingdomFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, BrazilManchester Fungal Infection Group (MFIG), Division of Evolution, Infection, and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United KingdomABSTRACT Antifungal drug tolerance and persistence are being increasingly recognized in fungal pathogens. Accordingly, more and more research is being carried out to characterize and understand these phenomena. However, the terminology and methodology employed in the fungal community lack consensus, particularly for filamentous fungi, as they present further complexities when compared to single-celled microorganisms. Hence, with the aim to ensure consistency in the literature, in this Perspective article, we propose tailored definitions for tolerance and persistence in filamentous fungi and suggest methods to detect and investigate these phenomena in the laboratory.https://journals.asm.org/doi/10.1128/mbio.03475-24antifungal toleranceantifungal persistenceantifungal drugsfilamentous fungi |
| spellingShingle | Jorge Amich Michael Bromley Gustavo H. Goldman Clara Valero Toward the consensus of definitions for the phenomena of antifungal tolerance and persistence in filamentous fungi mBio antifungal tolerance antifungal persistence antifungal drugs filamentous fungi |
| title | Toward the consensus of definitions for the phenomena of antifungal tolerance and persistence in filamentous fungi |
| title_full | Toward the consensus of definitions for the phenomena of antifungal tolerance and persistence in filamentous fungi |
| title_fullStr | Toward the consensus of definitions for the phenomena of antifungal tolerance and persistence in filamentous fungi |
| title_full_unstemmed | Toward the consensus of definitions for the phenomena of antifungal tolerance and persistence in filamentous fungi |
| title_short | Toward the consensus of definitions for the phenomena of antifungal tolerance and persistence in filamentous fungi |
| title_sort | toward the consensus of definitions for the phenomena of antifungal tolerance and persistence in filamentous fungi |
| topic | antifungal tolerance antifungal persistence antifungal drugs filamentous fungi |
| url | https://journals.asm.org/doi/10.1128/mbio.03475-24 |
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