Efficacy and safety of ACEI/ARB drug plus Yishenhuashi Granule: a Meta-analysis
Objective To systematically evaluate the efficacy and safety of Yishenhuashi Granule plus ACEI/ARB drug for chronic glomerulonephritis（CGN）and provide evidence-based references for clinical practices.Methods Randomized control trials（CTs）and quasi-randomized control trials（qRCTS）related to treating...
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Editorial Department of Journal of Clinical Nephrology
2021-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| author | Zhao Qing Zhen Min Yang Yu-feng Wu Yi-lian Shu Wei |
| author_facet | Zhao Qing Zhen Min Yang Yu-feng Wu Yi-lian Shu Wei |
| author_sort | Zhao Qing |
| collection | DOAJ |
| description | Objective To systematically evaluate the efficacy and safety of Yishenhuashi Granule plus ACEI/ARB drug for chronic glomerulonephritis（CGN）and provide evidence-based references for clinical practices.Methods Randomized control trials（CTs）and quasi-randomized control trials（qRCTS）related to treating CGN with Yishenhuashi Granule plus ACEI/ARB drug were collected from the databases of PubMed, Embase, Cochrane Library, CNKI,WangFang, VIP and CBM.The quality of included studies was evaluated and RewMAN 5.3 utilized for data analysis.Results Twenty eligible studies of 2885 cases were finally included.Meta-analysis indicated that Yishenhuashi Granule plus ACEI/ARB drug could improve clinical efficacy of CGN [OR=4.46,95%CI（3.45,5.76）] through reducing serum creatinine（Scr）（MD=-17.70,95%CI（-22.74,-12.66）,P<0.01）,urinary nitrogen（BUN）（MD=-1.67,95%CI（-1.89,-1.46）,P<0.01）,urinary protein quantification（24 hUTP）[MD=-0.41,95%CI（-0.45,-0.36）] and plasma albumin（Alb）[MD=2.34,95%CI（0.88,3.80）] without a greater incidence of adverse reactions.However, there was no obvious effect in lowering hematuria [MD=-1.71,95%CI（-4.38,0.86）,P=0.19].Conclusions As compared with ACEI/ARB drug alone, Yishenhuashi Granule plus ACEI/ARB drug can improve overall effective rate and restore renal function.And more clinical proofs are required for further validation due to limited quantity/quality of included studies. |
| format | Article |
| id | doaj-art-e36451298a7c4edb9876a3502ec18a96 |
| institution | Kabale University |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2021-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-e36451298a7c4edb9876a3502ec18a962025-08-20T03:48:58ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902021-01-012189590357902679Efficacy and safety of ACEI/ARB drug plus Yishenhuashi Granule: a Meta-analysisZhao QingZhen MinYang Yu-fengWu Yi-lianShu WeiObjective To systematically evaluate the efficacy and safety of Yishenhuashi Granule plus ACEI/ARB drug for chronic glomerulonephritis（CGN）and provide evidence-based references for clinical practices.Methods Randomized control trials（CTs）and quasi-randomized control trials（qRCTS）related to treating CGN with Yishenhuashi Granule plus ACEI/ARB drug were collected from the databases of PubMed, Embase, Cochrane Library, CNKI,WangFang, VIP and CBM.The quality of included studies was evaluated and RewMAN 5.3 utilized for data analysis.Results Twenty eligible studies of 2885 cases were finally included.Meta-analysis indicated that Yishenhuashi Granule plus ACEI/ARB drug could improve clinical efficacy of CGN [OR=4.46,95%CI（3.45,5.76）] through reducing serum creatinine（Scr）（MD=-17.70,95%CI（-22.74,-12.66）,P<0.01）,urinary nitrogen（BUN）（MD=-1.67,95%CI（-1.89,-1.46）,P<0.01）,urinary protein quantification（24 hUTP）[MD=-0.41,95%CI（-0.45,-0.36）] and plasma albumin（Alb）[MD=2.34,95%CI（0.88,3.80）] without a greater incidence of adverse reactions.However, there was no obvious effect in lowering hematuria [MD=-1.71,95%CI（-4.38,0.86）,P=0.19].Conclusions As compared with ACEI/ARB drug alone, Yishenhuashi Granule plus ACEI/ARB drug can improve overall effective rate and restore renal function.And more clinical proofs are required for further validation due to limited quantity/quality of included studies.http://www.lcszb.com/thesisDetails?columnId=57902679&Fpath=home&index=0Yishenhuashi GranuleACEI/ARB drugchronic nephritisMeta-analysis |
| spellingShingle | Zhao Qing Zhen Min Yang Yu-feng Wu Yi-lian Shu Wei Efficacy and safety of ACEI/ARB drug plus Yishenhuashi Granule: a Meta-analysis Linchuang shenzangbing zazhi Yishenhuashi Granule ACEI/ARB drug chronic nephritis Meta-analysis |
| title | Efficacy and safety of ACEI/ARB drug plus Yishenhuashi Granule: a Meta-analysis |
| title_full | Efficacy and safety of ACEI/ARB drug plus Yishenhuashi Granule: a Meta-analysis |
| title_fullStr | Efficacy and safety of ACEI/ARB drug plus Yishenhuashi Granule: a Meta-analysis |
| title_full_unstemmed | Efficacy and safety of ACEI/ARB drug plus Yishenhuashi Granule: a Meta-analysis |
| title_short | Efficacy and safety of ACEI/ARB drug plus Yishenhuashi Granule: a Meta-analysis |
| title_sort | efficacy and safety of acei arb drug plus yishenhuashi granule a meta analysis |
| topic | Yishenhuashi Granule ACEI/ARB drug chronic nephritis Meta-analysis |
| url | http://www.lcszb.com/thesisDetails?columnId=57902679&Fpath=home&index=0 |
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