Dynamics of Cognitive Impairment in Older Adults Linked to Suicide-Related Single-Nucleotide Polymorphisms: A 3-Year Follow-Up Study
Background: Cognitive decline during aging is a factor that inevitably affects everyone. In some older adults, cognitive function declines more rapidly to mild cognitive impairment (MCI) and eventually dementia. Our work aimed to determine the associations between suicide-related single-nucleotide g...
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MDPI AG
2025-06-01
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| Online Access: | https://www.mdpi.com/2673-5318/6/2/64 |
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| author | Yana Zorkina Alexander Berdalin Irina Morozova Alisa Andryushchenko Konstantin Pavlov Olga Pavlova Olga Abramova Valeriya Ushakova Angelina Zeltzer Marat Kurmishev Victor Savilov Olga Karpenko Georgy Kostyuk Anna Morozova |
| author_facet | Yana Zorkina Alexander Berdalin Irina Morozova Alisa Andryushchenko Konstantin Pavlov Olga Pavlova Olga Abramova Valeriya Ushakova Angelina Zeltzer Marat Kurmishev Victor Savilov Olga Karpenko Georgy Kostyuk Anna Morozova |
| author_sort | Yana Zorkina |
| collection | DOAJ |
| description | Background: Cognitive decline during aging is a factor that inevitably affects everyone. In some older adults, cognitive function declines more rapidly to mild cognitive impairment (MCI) and eventually dementia. Our work aimed to determine the associations between suicide-related single-nucleotide genetic polymorphisms (SNPs) and cognitive function dynamics in people over 65 years old over a three-year follow-up. Suicide-related SNPs have already shown an association with dementia in our previous study. Methods: The present study included 66 participants over 65 without subjective cognitive decline. Cognitive impairment was assessed at two follow-up points (at the start of the study in 2020–2021 and 3 years later) using the Montreal Cognitive Assessment (MoCA). Patients were also genotyped for 16 SNPs. Results: We found associations between <i>rs10898553</i> and <i>rs165774</i> and MoCA 3-year dynamics, with a certain genetic variant related to more significant progression. For <i>rs7982251</i>, associations with scale scores were found, but no effect on its dynamics. Conclusions: The research focused on analyzing genetic factors of cognitive decline in healthy older adults without subjective cognitive decline. Identifying these markers can help predict the development of pathology at early stages and start timely treatment. |
| format | Article |
| id | doaj-art-e35a65eea9b04abaab9e66cd2958b63e |
| institution | OA Journals |
| issn | 2673-5318 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Psychiatry International |
| spelling | doaj-art-e35a65eea9b04abaab9e66cd2958b63e2025-08-20T02:21:53ZengMDPI AGPsychiatry International2673-53182025-06-01626410.3390/psychiatryint6020064Dynamics of Cognitive Impairment in Older Adults Linked to Suicide-Related Single-Nucleotide Polymorphisms: A 3-Year Follow-Up StudyYana Zorkina0Alexander Berdalin1Irina Morozova2Alisa Andryushchenko3Konstantin Pavlov4Olga Pavlova5Olga Abramova6Valeriya Ushakova7Angelina Zeltzer8Marat Kurmishev9Victor Savilov10Olga Karpenko11Georgy Kostyuk12Anna Morozova13Mental-Health Clinic No. 1 Named After N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaMental-Health Clinic No. 1 Named After N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaMental-Health Clinic No. 1 Named After N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaMental-Health Clinic No. 1 Named After N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaMental-Health Clinic No. 1 Named After N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaDepartment of Basic and Applied Neurobiology, V. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Kropotkinsky per. 23, 119034 Moscow, RussiaMental-Health Clinic No. 1 Named After N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaMental-Health Clinic No. 1 Named After N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaMental-Health Clinic No. 1 Named After N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaMental-Health Clinic No. 1 Named After N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaMental-Health Clinic No. 1 Named After N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaMental-Health Clinic No. 1 Named After N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaMental-Health Clinic No. 1 Named After N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaMental-Health Clinic No. 1 Named After N.A. Alekseev, Zagorodnoe Highway 2, 115191 Moscow, RussiaBackground: Cognitive decline during aging is a factor that inevitably affects everyone. In some older adults, cognitive function declines more rapidly to mild cognitive impairment (MCI) and eventually dementia. Our work aimed to determine the associations between suicide-related single-nucleotide genetic polymorphisms (SNPs) and cognitive function dynamics in people over 65 years old over a three-year follow-up. Suicide-related SNPs have already shown an association with dementia in our previous study. Methods: The present study included 66 participants over 65 without subjective cognitive decline. Cognitive impairment was assessed at two follow-up points (at the start of the study in 2020–2021 and 3 years later) using the Montreal Cognitive Assessment (MoCA). Patients were also genotyped for 16 SNPs. Results: We found associations between <i>rs10898553</i> and <i>rs165774</i> and MoCA 3-year dynamics, with a certain genetic variant related to more significant progression. For <i>rs7982251</i>, associations with scale scores were found, but no effect on its dynamics. Conclusions: The research focused on analyzing genetic factors of cognitive decline in healthy older adults without subjective cognitive decline. Identifying these markers can help predict the development of pathology at early stages and start timely treatment.https://www.mdpi.com/2673-5318/6/2/64cognitive impairmentolder adultssingle-nucleotide polymorphism<i>rs10898553</i><i>rs165774</i><i>rs7982251</i> |
| spellingShingle | Yana Zorkina Alexander Berdalin Irina Morozova Alisa Andryushchenko Konstantin Pavlov Olga Pavlova Olga Abramova Valeriya Ushakova Angelina Zeltzer Marat Kurmishev Victor Savilov Olga Karpenko Georgy Kostyuk Anna Morozova Dynamics of Cognitive Impairment in Older Adults Linked to Suicide-Related Single-Nucleotide Polymorphisms: A 3-Year Follow-Up Study Psychiatry International cognitive impairment older adults single-nucleotide polymorphism <i>rs10898553</i> <i>rs165774</i> <i>rs7982251</i> |
| title | Dynamics of Cognitive Impairment in Older Adults Linked to Suicide-Related Single-Nucleotide Polymorphisms: A 3-Year Follow-Up Study |
| title_full | Dynamics of Cognitive Impairment in Older Adults Linked to Suicide-Related Single-Nucleotide Polymorphisms: A 3-Year Follow-Up Study |
| title_fullStr | Dynamics of Cognitive Impairment in Older Adults Linked to Suicide-Related Single-Nucleotide Polymorphisms: A 3-Year Follow-Up Study |
| title_full_unstemmed | Dynamics of Cognitive Impairment in Older Adults Linked to Suicide-Related Single-Nucleotide Polymorphisms: A 3-Year Follow-Up Study |
| title_short | Dynamics of Cognitive Impairment in Older Adults Linked to Suicide-Related Single-Nucleotide Polymorphisms: A 3-Year Follow-Up Study |
| title_sort | dynamics of cognitive impairment in older adults linked to suicide related single nucleotide polymorphisms a 3 year follow up study |
| topic | cognitive impairment older adults single-nucleotide polymorphism <i>rs10898553</i> <i>rs165774</i> <i>rs7982251</i> |
| url | https://www.mdpi.com/2673-5318/6/2/64 |
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