The brown fat-specific overexpression of RBP4 improves thermoregulation and systemic metabolism by activating the canonical adrenergic signaling pathway

The brown fat-specific overexpression of RBP4 improves thermoregulation and systemic metabolism by activating the canonical adrenergic signaling pathway

Abstract Retinol-binding protein 4 (RBP4), the sole specific carrier for retinol (vitamin A) in circulation, is highly expressed in liver and adipose tissues. Previous studies have demonstrated that RBP4 plays a role in cold-mediated adipose tissue browning and thermogenesis. However, the role of RB...

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Main Authors: Jong Yoen Park, Eun Sun Ha, Jimin Lee, Pierre-Jacques Brun, Yeri Kim, Sung Soo Chung, Daehee Hwang, Seung-Ah Lee, Kyong Soo Park
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-025-01411-6
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https://doi.org/10.1038/s12276-025-01411-6

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