Neurotrophic Receptor Tyrosine Kinase 3 as a Prognostic Biomarker in Breast Cancer Using Bioinformatic Analysis
<i>Background and Objectives</i>: Neurotrophic receptor tyrosine kinase 3 (<i>NTRK3</i>) is a member of the tropomyosin receptor kinase family of receptor tyrosine kinases, which play a crucial role in neural development. However, owing to the limited number of studies about...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/61/3/474 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850091402830020608 |
|---|---|
| author | Jeongmin Choi Jongwan Kim Yong Wook Jung Jong Ho Park Jae-Ho Lee |
| author_facet | Jeongmin Choi Jongwan Kim Yong Wook Jung Jong Ho Park Jae-Ho Lee |
| author_sort | Jeongmin Choi |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Neurotrophic receptor tyrosine kinase 3 (<i>NTRK3</i>) is a member of the tropomyosin receptor kinase family of receptor tyrosine kinases, which play a crucial role in neural development. However, owing to the limited number of studies about <i>NTRK3</i> and cancer, we aimed to investigate <i>NTRK3</i> as a potential prognostic marker for breast cancer (BC). <i>Materials and Methods</i>: We conducted a comprehensive analysis of <i>NTRK3</i> expression in BC using the Tumor Immune Estimation Resource, Gene Expression Profiling Interactive Analysis 2, and Kaplan–Meier Plotter databases. We also explored the association between <i>NTRK3</i> expression and tumor-infiltrating immune cells. <i>Results</i>: Low <i>NTRK3</i> expression showed poorer prognosis in BC, as well as with T stage, pathology, and the Luminal subtype. In BC (BRCA), <i>NTRK3</i> was positively correlated with CD4+ T cell, CD8+ T cell, macrophage, and neutrophil infiltration. <i>Conclusions</i>: These results suggest that <i>NTRK3</i> may serve as a prognostic biomarker and provide novel insights into tumor immunology in BC. Therefore, <i>NTRK3</i> represents a potential diagnostic and therapeutic target for BC treatment. |
| format | Article |
| id | doaj-art-e351dc7ae94540c0a2e1b7f8ab1864bd |
| institution | DOAJ |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj-art-e351dc7ae94540c0a2e1b7f8ab1864bd2025-08-20T02:42:22ZengMDPI AGMedicina1010-660X1648-91442025-03-0161347410.3390/medicina61030474Neurotrophic Receptor Tyrosine Kinase 3 as a Prognostic Biomarker in Breast Cancer Using Bioinformatic AnalysisJeongmin Choi0Jongwan Kim1Yong Wook Jung2Jong Ho Park3Jae-Ho Lee4Medical Course, School of Medicine, Keimyung University, 1095 Dalgubeol-daero, Daegu 42601, Republic of KoreaDepartment of Anatomy, College of Medicine, Dongguk University, Gyeongju 38066, Republic of KoreaDepartment of Anatomy, College of Medicine, Dongguk University, Gyeongju 38066, Republic of KoreaDepartment of Anatomy, School of Medicine, Keimyung University, 1095 Dalgubeol-daero, Daegu 42601, Republic of KoreaDepartment of Anatomy, School of Medicine, Keimyung University, 1095 Dalgubeol-daero, Daegu 42601, Republic of Korea<i>Background and Objectives</i>: Neurotrophic receptor tyrosine kinase 3 (<i>NTRK3</i>) is a member of the tropomyosin receptor kinase family of receptor tyrosine kinases, which play a crucial role in neural development. However, owing to the limited number of studies about <i>NTRK3</i> and cancer, we aimed to investigate <i>NTRK3</i> as a potential prognostic marker for breast cancer (BC). <i>Materials and Methods</i>: We conducted a comprehensive analysis of <i>NTRK3</i> expression in BC using the Tumor Immune Estimation Resource, Gene Expression Profiling Interactive Analysis 2, and Kaplan–Meier Plotter databases. We also explored the association between <i>NTRK3</i> expression and tumor-infiltrating immune cells. <i>Results</i>: Low <i>NTRK3</i> expression showed poorer prognosis in BC, as well as with T stage, pathology, and the Luminal subtype. In BC (BRCA), <i>NTRK3</i> was positively correlated with CD4+ T cell, CD8+ T cell, macrophage, and neutrophil infiltration. <i>Conclusions</i>: These results suggest that <i>NTRK3</i> may serve as a prognostic biomarker and provide novel insights into tumor immunology in BC. Therefore, <i>NTRK3</i> represents a potential diagnostic and therapeutic target for BC treatment.https://www.mdpi.com/1648-9144/61/3/474breast cancerneurotrophic receptor tyrosine kinase 3prognosisimmune cellsbiomarker |
| spellingShingle | Jeongmin Choi Jongwan Kim Yong Wook Jung Jong Ho Park Jae-Ho Lee Neurotrophic Receptor Tyrosine Kinase 3 as a Prognostic Biomarker in Breast Cancer Using Bioinformatic Analysis Medicina breast cancer neurotrophic receptor tyrosine kinase 3 prognosis immune cells biomarker |
| title | Neurotrophic Receptor Tyrosine Kinase 3 as a Prognostic Biomarker in Breast Cancer Using Bioinformatic Analysis |
| title_full | Neurotrophic Receptor Tyrosine Kinase 3 as a Prognostic Biomarker in Breast Cancer Using Bioinformatic Analysis |
| title_fullStr | Neurotrophic Receptor Tyrosine Kinase 3 as a Prognostic Biomarker in Breast Cancer Using Bioinformatic Analysis |
| title_full_unstemmed | Neurotrophic Receptor Tyrosine Kinase 3 as a Prognostic Biomarker in Breast Cancer Using Bioinformatic Analysis |
| title_short | Neurotrophic Receptor Tyrosine Kinase 3 as a Prognostic Biomarker in Breast Cancer Using Bioinformatic Analysis |
| title_sort | neurotrophic receptor tyrosine kinase 3 as a prognostic biomarker in breast cancer using bioinformatic analysis |
| topic | breast cancer neurotrophic receptor tyrosine kinase 3 prognosis immune cells biomarker |
| url | https://www.mdpi.com/1648-9144/61/3/474 |
| work_keys_str_mv | AT jeongminchoi neurotrophicreceptortyrosinekinase3asaprognosticbiomarkerinbreastcancerusingbioinformaticanalysis AT jongwankim neurotrophicreceptortyrosinekinase3asaprognosticbiomarkerinbreastcancerusingbioinformaticanalysis AT yongwookjung neurotrophicreceptortyrosinekinase3asaprognosticbiomarkerinbreastcancerusingbioinformaticanalysis AT jonghopark neurotrophicreceptortyrosinekinase3asaprognosticbiomarkerinbreastcancerusingbioinformaticanalysis AT jaeholee neurotrophicreceptortyrosinekinase3asaprognosticbiomarkerinbreastcancerusingbioinformaticanalysis |